| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tofacitinib (citrate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.153642 |
| FN1 | fibronectin 1 | 0.133988 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0887686 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0720439 |
| ENO1 | enolase 1, (alpha) | 0.0719005 |
| CENPF | centromere protein F, 350/400kDa | 0.0660422 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.065965 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0633077 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0600015 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0573576 |
| CD109 | CD109 molecule | 0.0553808 |
| NAV2 | neuron navigator 2 | 0.0547171 |
| RNF145 | ring finger protein 145 | 0.0533747 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0503105 |
| VEGFA | vascular endothelial growth factor A | 0.0487709 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0456606 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0451077 |
| RTN4 | reticulon 4 | 0.0446011 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0427691 |
| SRPK2 | SRSF protein kinase 2 | 0.0422616 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0401033 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0390837 |
| NPC1 | Niemann-Pick disease, type C1 | 0.038743 |
| VMP1 | vacuole membrane protein 1 | 0.0373264 |
| POM121C | POM121 transmembrane nucleoporin C | 0.0363883 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0354555 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0348008 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0347535 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.0346977 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0345431 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.033637 |
| PI15 | peptidase inhibitor 15 | 0.0332336 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.0331563 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0329049 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 0.0309914 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0304851 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0302361 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0293871 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0293611 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0292306 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0291625 |
| TXNIP | thioredoxin interacting protein | 0.0287385 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0286432 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0282444 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0282083 |
| MSN | moesin | 0.0281537 |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.0277967 |
| TPR | translocated promoter region, nuclear basket protein | 0.027752 |
| RO60 | Ro60, Y RNA binding protein | 0.0268278 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0267282 |
| ZYX | zyxin | 0.0265861 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0258856 |
| IL6ST | interleukin 6 signal transducer | 0.0256776 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0256543 |
| COPA | coatomer protein complex, subunit alpha | 0.024988 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0248909 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0248865 |
| CDK19 | cyclin-dependent kinase 19 | 0.0248808 |
| NOTCH2 | notch 2 | 0.0247986 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0243663 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.024051 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0239627 |
| LDHA | lactate dehydrogenase A | 0.0237645 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0235905 |
| WASL | Wiskott-Aldrich syndrome-like | 0.0233898 |
| SBF2 | SET binding factor 2 | 0.0233767 |
| MKI67 | marker of proliferation Ki-67 | 0.0232098 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | 0.0230905 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0228683 |
| ACTN1 | actinin, alpha 1 | 0.0228641 |
| FOSL1 | FOS-like antigen 1 | 0.0224395 |
| SOX13 | SRY (sex determining region Y)-box 13 | 0.0224304 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.022272 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0220405 |
| LAMB1 | laminin, beta 1 | 0.021999 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.0217888 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0215371 |
| TES | testin LIM domain protein | 0.0213459 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0212796 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0211521 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0210624 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0209124 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.020783 |
| RCAN1 | regulator of calcineurin 1 | 0.0206781 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0206768 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0203707 |
| NBAS | neuroblastoma amplified sequence | 0.0203256 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0200739 |
| ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1) | 0.0200269 |
| FBXO7 | F-box protein 7 | 0.0199584 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0198125 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0197769 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0194185 |
| COL19A1 | collagen, type XIX, alpha 1 | 0.0193754 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0193165 |
| CLIC4 | chloride intracellular channel 4 | 0.0190631 |
| TNPO3 | transportin 3 | 0.0190325 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0189948 |
| HDAC9 | histone deacetylase 9 | 0.0188063 |
| RBM6 | RNA binding motif protein 6 | 0.0186657 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.182586 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.156294 |
| VGF | VGF nerve growth factor inducible | -0.14334 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.110277 |
| VIM | vimentin | -0.0996218 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0963255 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0912224 |
| TMSB10 | thymosin beta 10 | -0.0834085 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0775437 |
| HLA-B | major histocompatibility complex, class I, B | -0.0740236 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0686834 |
| S100A6 | S100 calcium binding protein A6 | -0.0676936 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0676635 |
| IER3 | immediate early response 3 | -0.0609832 |
| NLGN1 | neuroligin 1 | -0.0584429 |
| ACTG1 | actin gamma 1 | -0.0532053 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0502633 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0497212 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0486178 |
| NPR2 | natriuretic peptide receptor 2 | -0.0477128 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0476192 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0470815 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0469078 |
| PGK1 | phosphoglycerate kinase 1 | -0.0466106 |
| GNAS | GNAS complex locus | -0.0425715 |
| RPLP1 | ribosomal protein, large, P1 | -0.0424645 |
| NAV1 | neuron navigator 1 | -0.0423886 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0407732 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.040318 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0395244 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0380205 |
| LMNA | lamin A/C | -0.0375055 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0373232 |
| MACROD2 | MACRO domain containing 2 | -0.0363137 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0362724 |
| TBC1D22A | TBC1 domain family, member 22A | -0.03536 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.035306 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0350156 |
| NDRG1 | N-myc downstream regulated 1 | -0.0343355 |
| TLE4 | transducin-like enhancer of split 4 | -0.034209 |
| PHF21A | PHD finger protein 21A | -0.0339575 |
| PTCHD4 | patched domain containing 4 | -0.0337967 |
| CDK14 | cyclin-dependent kinase 14 | -0.0337581 |
| RRBP1 | ribosome binding protein 1 | -0.0335295 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0334415 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0326402 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0326069 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0326036 |
| ZNF704 | zinc finger protein 704 | -0.0325893 |
| RYBP | RING1 and YY1 binding protein | -0.0323453 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0322363 |
| INSIG1 | insulin induced gene 1 | -0.0312557 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0311248 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0308328 |
| LRRC23 | leucine rich repeat containing 23 | -0.03072 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0302355 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0302042 |
| CADM1 | cell adhesion molecule 1 | -0.0301176 |
| FUS | FUS RNA binding protein | -0.0300061 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0295858 |
| PTMA | prothymosin, alpha | -0.0292521 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0292275 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0289695 |
| SCFD2 | sec1 family domain containing 2 | -0.0288032 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | -0.0287568 |
| PCDH7 | protocadherin 7 | -0.0283309 |
| PAX3 | paired box 3 | -0.0282768 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0282229 |
| NAV3 | neuron navigator 3 | -0.0274491 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.027307 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0267169 |
| HMGB1 | high mobility group box 1 | -0.0267089 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0266698 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0266625 |
| CTSD | cathepsin D | -0.0265955 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0264672 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0261782 |
| RHEB | Ras homolog enriched in brain | -0.0259846 |
| MEIS2 | Meis homeobox 2 | -0.025929 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0254701 |
| TFRC | transferrin receptor | -0.0254603 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0253573 |
| ASPH | aspartate beta-hydroxylase | -0.0253475 |
| INTS6 | integrator complex subunit 6 | -0.0253178 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.025232 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0247979 |
| CAVIN1 | caveolae associated protein 1 | -0.0245841 |
| FTL | ferritin, light polypeptide | -0.0239524 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0238706 |
| TRIM2 | tripartite motif containing 2 | -0.0234959 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.0234781 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0234567 |
| SSH1 | slingshot protein phosphatase 1 | -0.0234277 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0232593 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0230142 |
| RNF24 | ring finger protein 24 | -0.0228579 |
| GSN | gelsolin | -0.0226225 |
| TMEM123 | transmembrane protein 123 | -0.0225867 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.0225231 |
| LSAMP | limbic system-associated membrane protein | -0.0223907 |
