| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LAMB3 | laminin, beta 3 | 0.161119 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.141992 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.129768 |
| VEGFA | vascular endothelial growth factor A | 0.084591 |
| APOL1 | apolipoprotein L, 1 | 0.0705063 |
| DTNA | dystrobrevin, alpha | 0.0659922 |
| B2M | beta-2-microglobulin | 0.0627577 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0619304 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0607969 |
| TGM2 | transglutaminase 2 | 0.048868 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0478108 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0467874 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.045374 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0444623 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0440174 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0431456 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0405604 |
| MCL1 | myeloid cell leukemia 1 | 0.0404393 |
| OPTN | optineurin | 0.0390635 |
| PLEC | plectin | 0.0386358 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0384737 |
| SEPTIN9 | septin 9 | 0.0383917 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0376067 |
| NDRG1 | N-myc downstream regulated 1 | 0.0372715 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0364792 |
| LAMC2 | laminin, gamma 2 | 0.0362997 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0360202 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.035993 |
| SMAD3 | SMAD family member 3 | 0.0356912 |
| RNASET2 | ribonuclease T2 | 0.0348593 |
| TPM3 | tropomyosin 3 | 0.0348146 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0342026 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0338851 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0334542 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0326814 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0320131 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0316279 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0311122 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0307041 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0302706 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0292248 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.029043 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0286466 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0284418 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0279684 |
| ADAM28 | ADAM metallopeptidase domain 28 | 0.0278597 |
| ATXN1 | ataxin 1 | 0.0275058 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.027234 |
| TMF1 | TATA element modulatory factor 1 | 0.027072 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0267871 |
| AXL | AXL receptor tyrosine kinase | 0.0258675 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.025736 |
| HLA-A | major histocompatibility complex, class I, A | 0.025723 |
| CCNL1 | cyclin L1 | 0.0253571 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0252632 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0245608 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0245152 |
| TMC5 | transmembrane channel-like 5 | 0.0243605 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0243516 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0242291 |
| BARX2 | BARX homeobox 2 | 0.023958 |
| CDCP1 | CUB domain containing protein 1 | 0.0239541 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.023807 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0236983 |
| MYO5B | myosin VB | 0.0232896 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0232297 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0231743 |
| ANXA11 | annexin A11 | 0.0231682 |
| JUN | jun proto-oncogene | 0.0231441 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.022823 |
| ITPKC | inositol-trisphosphate 3-kinase C | 0.0227263 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0225546 |
| TMEM51 | transmembrane protein 51 | 0.0222203 |
| CASC3 | cancer susceptibility candidate 3 | 0.0218714 |
| DUOX2 | dual oxidase 2 | 0.0217567 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.021741 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0214623 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0213359 |
| MSN | moesin | 0.0212535 |
| SGMS2 | sphingomyelin synthase 2 | 0.0212437 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0210717 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0208775 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | 0.020708 |
| APP | amyloid beta (A4) precursor protein | 0.0204832 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0204338 |
| EGR1 | early growth response 1 | 0.0204313 |
| ARRDC3 | arrestin domain containing 3 | 0.020399 |
| FAM117B | family with sequence similarity 117, member B | 0.0203413 |
| JMJD1C | jumonji domain containing 1C | 0.0203318 |
| MT1G | metallothionein 1G | 0.0201282 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0201069 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0199909 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0197436 |
| MXD1 | MAX dimerization protein 1 | 0.0195196 |
| KIAA1217 | KIAA1217 | 0.0195005 |
| DUSP5 | dual specificity phosphatase 5 | 0.0193298 |
| C3 | complement component 3 | 0.0190542 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0188613 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0187483 |
| RASA3 | RAS p21 protein activator 3 | 0.018677 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.210928 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.179655 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.169982 |
| PTMA | prothymosin, alpha | -0.145807 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.110279 |
| ASPH | aspartate beta-hydroxylase | -0.109617 |
| MMP7 | matrix metallopeptidase 7 | -0.10393 |
| MT1X | metallothionein 1X | -0.0977618 |
| ANXA2 | annexin A2 | -0.0935351 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.090323 |
| ACTG1 | actin gamma 1 | -0.0819148 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0752128 |
| RPLP1 | ribosomal protein, large, P1 | -0.074742 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0741849 |
| GNAS | GNAS complex locus | -0.074158 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0724054 |
| FTL | ferritin, light polypeptide | -0.0688461 |
| RPL19 | ribosomal protein L19 | -0.067129 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0662331 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0629829 |
| UBC | ubiquitin C | -0.0628328 |
| KLF6 | Kruppel-like factor 6 | -0.0624865 |
| RBM39 | RNA binding motif protein 39 | -0.0614121 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0611395 |
| S100A6 | S100 calcium binding protein A6 | -0.0597101 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0588584 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0575729 |
| VIM | vimentin | -0.0568425 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0566163 |
| TMEM123 | transmembrane protein 123 | -0.0561049 |
| VCL | vinculin | -0.0546661 |
| MYOF | myoferlin | -0.0545707 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0544816 |
| BICC1 | BicC family RNA binding protein 1 | -0.0538076 |
| EREG | epiregulin | -0.0523522 |
| IER3 | immediate early response 3 | -0.0518658 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0512594 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.051168 |
| LDHA | lactate dehydrogenase A | -0.0503118 |
| HLA-B | major histocompatibility complex, class I, B | -0.0501628 |
| RPLP0 | ribosomal protein, large, P0 | -0.046588 |
| PLAU | plasminogen activator, urokinase | -0.0465602 |
| PGK1 | phosphoglycerate kinase 1 | -0.046074 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0457374 |
| RPL23 | ribosomal protein L23 | -0.0450471 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0450255 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0426582 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0419 |
| CANX | calnexin | -0.0410591 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0398791 |
| PRKCA | protein kinase C, alpha | -0.0389845 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0382995 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0382406 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.038094 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0366632 |
| SYNRG | synergin, gamma | -0.0363443 |
| MYO10 | myosin X | -0.0360154 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0359364 |
| TXNRD1 | thioredoxin reductase 1 | -0.0350627 |
| TSC22D2 | TSC22 domain family, member 2 | -0.034803 |
| ACTN4 | actinin, alpha 4 | -0.0343135 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0342565 |
| PKM | pyruvate kinase, muscle | -0.0340698 |
| RPL34 | ribosomal protein L34 | -0.0335288 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0332813 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0331497 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0331005 |
| TMEM263 | transmembrane protein 263 | -0.0330609 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0329861 |
| MORF4L2 | mortality factor 4 like 2 | -0.0329761 |
| ARF1 | ADP-ribosylation factor 1 | -0.0325199 |
| RPL35A | ribosomal protein L35a | -0.032482 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0323954 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0322713 |
| MYO1E | myosin IE | -0.0319794 |
| RPL4 | ribosomal protein L4 | -0.031936 |
| SPAG9 | sperm associated antigen 9 | -0.0316726 |
| KRT8 | keratin 8, type II | -0.0316058 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0312404 |
| RPS24 | ribosomal protein S24 | -0.031175 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0311234 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0309243 |
| H1-0 | H1.0 linker histone | -0.0308494 |
| HKDC1 | hexokinase domain containing 1 | -0.030627 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0304459 |
| MKI67 | marker of proliferation Ki-67 | -0.0296904 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0295503 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.0294353 |
| RTN4 | reticulon 4 | -0.0292428 |
| RTN3 | reticulon 3 | -0.0290556 |
| CDK6 | cyclin-dependent kinase 6 | -0.0290506 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0290501 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0289586 |
| RPS23 | ribosomal protein S23 | -0.028909 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.028848 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0288427 |
| INTS6 | integrator complex subunit 6 | -0.0287004 |
| ZNF207 | zinc finger protein 207 | -0.0286112 |
| AGR2 | anterior gradient 2 | -0.0285802 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0283239 |
