Tofacitinib (citrate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tofacitinib (citrate) perturbation in H4 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Tofacitinib (citrate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.198188
VEGFA vascular endothelial growth factor A 0.0870435
B2M beta-2-microglobulin 0.0776794
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0711508
BACE2 beta-site APP-cleaving enzyme 2 0.0612421
FTH1 ferritin, heavy polypeptide 1 0.0611561
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0602462
FAM13A family with sequence similarity 13, member A 0.054274
TTC3 tetratricopeptide repeat domain 3 0.0511437
HLA-A major histocompatibility complex, class I, A 0.0506765
ZCCHC7 zinc finger, CCHC domain containing 7 0.0448754
EXT1 exostosin glycosyltransferase 1 0.0437035
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0393787
CLMP CXADR-like membrane protein 0.0388858
AKAP9 A kinase (PRKA) anchor protein 9 0.0386968
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0383256
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0353478
ARHGAP22 Rho GTPase activating protein 22 0.03517
AKAP12 A kinase (PRKA) anchor protein 12 0.0348556
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0343381
COPA coatomer protein complex, subunit alpha 0.031257
JARID2 jumonji, AT rich interactive domain 2 0.0297456
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0296801
TMED3 transmembrane emp24 protein transport domain containing 3 0.0296508
ESYT2 extended synaptotagmin-like protein 2 0.0293918
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0293749
GOLGA4 golgin A4 0.0280015
TP53BP1 tumor protein p53 binding protein 1 0.0279812
SETD5 SET domain containing 5 0.0277901
SRRM2 serine/arginine repetitive matrix 2 0.0271143
SMYD3 SET and MYND domain containing 3 0.0269465
COG5 component of oligomeric golgi complex 5 0.0266957
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.026652
LOXL2 lysyl oxidase-like 2 0.0263516
ATM ATM serine/threonine kinase 0.0253114
RAB7A RAB7A, member RAS oncogene family 0.0251063
GOLGB1 golgin B1 0.0251028
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0248083
TTC17 tetratricopeptide repeat domain 17 0.0247532
GPC5 glypican 5 0.0243019
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0241016
DTNA dystrobrevin, alpha 0.0238126
KMT2C lysine (K)-specific methyltransferase 2C 0.0233294
HDAC9 histone deacetylase 9 0.0231079
DOCK5 dedicator of cytokinesis 5 0.0230173
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0229519
GDF15 growth differentiation factor 15 0.0223265
C1S complement component 1, s subcomponent 0.0222005
MACF1 microtubule-actin crosslinking factor 1 0.021744
FAM219A family with sequence similarity 219, member A 0.0212905
DCAF10 DDB1 and CUL4 associated factor 10 0.0211923
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0209407
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.020907
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0208933
ARF4 ADP-ribosylation factor 4 0.020662
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0198282
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0197921
TMCC1 transmembrane and coiled-coil domain family 1 0.0194887
MYO9A myosin IXA 0.0194023
LAMB1 laminin, beta 1 0.019208
RAB2A RAB2A, member RAS oncogene family 0.0191718
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.0190696
BHLHE40 basic helix-loop-helix family, member e40 0.0190629
HLA-B major histocompatibility complex, class I, B 0.0188959
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0188306
PGM3 phosphoglucomutase 3 0.0187116
DENND5A DENN/MADD domain containing 5A 0.0186799
CALD1 caldesmon 1 0.0185739
GPR173 G protein-coupled receptor 173 0.0185425
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0185373
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0183565
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0183368
SRRM1 serine/arginine repetitive matrix 1 0.0183311
HELZ helicase with zinc finger 0.0182571
PICALM phosphatidylinositol binding clathrin assembly protein 0.0182458
MAST4 microtubule associated serine/threonine kinase family member 4 0.0181782
SND1 staphylococcal nuclease and tudor domain containing 1 0.0181618
NGLY1 N-glycanase 1 0.0181419
THOC2 THO complex 2 0.0181237
SEC24A SEC24 family member A 0.0179909
COL6A2 collagen, type VI, alpha 2 0.0179039
SCFD2 sec1 family domain containing 2 0.017848
PDS5A PDS5 cohesin associated factor A 0.0178247
ANKRD36 ankyrin repeat domain 36 0.0178015
MON2 MON2 homolog (S. cerevisiae) 0.0177763
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0176187
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0175809
SRP54 signal recognition particle 54kDa 0.017575
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0175182
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.0173647
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0172311
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0171757
MTREX Mtr4 exosome RNA helicase 0.0170671
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0170206
METTL15 methyltransferase like 15 0.0170172
BTG1 B-cell translocation gene 1, anti-proliferative 0.0169839
BRD4 bromodomain containing 4 0.0169331
RNMT RNA (guanine-7-) methyltransferase 0.0169183
ANKRD11 ankyrin repeat domain 11 0.0168481
TMEM41B transmembrane protein 41B 0.0168018

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.305687
FTL ferritin, light polypeptide -0.159988
TMSB10 thymosin beta 10 -0.0984437
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0941687
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0927381
SDK1 sidekick cell adhesion molecule 1 -0.0851203
VIM vimentin -0.0817278
DST dystonin -0.0779052
NDRG1 N-myc downstream regulated 1 -0.0729101
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0711513
PDE4D phosphodiesterase 4D, cAMP-specific -0.0700606
NAMPT nicotinamide phosphoribosyltransferase -0.0683742
LDHA lactate dehydrogenase A -0.0661558
RPS8 ribosomal protein S8 -0.0621183
PKM pyruvate kinase, muscle -0.0608962
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.059231
ZBTB20 zinc finger and BTB domain containing 20 -0.0556046
IGFBP5 insulin-like growth factor binding protein 5 -0.0508397
RPL28 ribosomal protein L28 -0.050392
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.049495
ALCAM activated leukocyte cell adhesion molecule -0.0491702
STK17A serine/threonine kinase 17a -0.0488527
RPLP1 ribosomal protein, large, P1 -0.0470008
LOX lysyl oxidase -0.0454969
TGFBI transforming growth factor, beta-induced, 68kDa -0.0440665
MT2A metallothionein 2A -0.0434078
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0431854
PGK1 phosphoglycerate kinase 1 -0.0429617
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0401449
SEPTIN7 septin 7 -0.0401069
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0398405
RPS6 ribosomal protein S6 -0.0398022
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0395894
FNDC3B fibronectin type III domain containing 3B -0.0388097
RPLP2 ribosomal protein, large, P2 -0.038452
AHNAK AHNAK nucleoprotein -0.0382285
TXNRD1 thioredoxin reductase 1 -0.0369452
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0362158
PHF14 PHD finger protein 14 -0.0360104
FER fer (fps/fes related) tyrosine kinase -0.0358575
RPS23 ribosomal protein S23 -0.0354532
PALLD palladin, cytoskeletal associated protein -0.0346685
VCL vinculin -0.0346259
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0341848
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.034015
RPS2 ribosomal protein S2 -0.0339814
RPS19 ribosomal protein S19 -0.0339518
MAP1B microtubule-associated protein 1B -0.033912
GARS1 glycyl-tRNA synthetase 1 -0.0337305
MKI67 marker of proliferation Ki-67 -0.0334274
FSTL1 follistatin-like 1 -0.0333453
GNAS GNAS complex locus -0.0331124
GPC6 glypican 6 -0.0329438
SQSTM1 sequestosome 1 -0.032791
RPL12 ribosomal protein L12 -0.0327003
CENPF centromere protein F, 350/400kDa -0.0314676
ENO1 enolase 1, (alpha) -0.0310886
AUTS2 autism susceptibility candidate 2 -0.0306822
PHF21A PHD finger protein 21A -0.0305535
PHIP pleckstrin homology domain interacting protein -0.0304988
TXNIP thioredoxin interacting protein -0.0299596
TAS2R14 taste receptor, type 2, member 14 -0.0298856
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.029871
RPL35A ribosomal protein L35a -0.0297862
ACTN4 actinin, alpha 4 -0.0297446
SMC4 structural maintenance of chromosomes 4 -0.0296013
RTN4 reticulon 4 -0.0296003
WWOX WW domain containing oxidoreductase -0.0295736
SBF2 SET binding factor 2 -0.0294706
RPL19 ribosomal protein L19 -0.0294298
SEC61G Sec61 gamma subunit -0.0291607
TPI1 triosephosphate isomerase 1 -0.0288477
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0288284
COL5A2 collagen, type V, alpha 2 -0.0288086
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0287869
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0286094
CENPE centromere protein E, 312kDa -0.0285428
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0280448
KCTD16 potassium channel tetramerization domain containing 16 -0.0278494
TNNC1 troponin C type 1 (slow) -0.0277673
OSMR oncostatin M receptor -0.0276654
IL6ST interleukin 6 signal transducer -0.0273082
RPL23 ribosomal protein L23 -0.027152
TUBB tubulin, beta class I -0.0267003
PTPRD protein tyrosine phosphatase, receptor type, D -0.0265195
GLIS3 GLIS family zinc finger 3 -0.0264984
PRDX1 peroxiredoxin 1 -0.0264982
KYNU kynureninase -0.0261719
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0259282
PTMA prothymosin, alpha -0.0258215
ASPH aspartate beta-hydroxylase -0.0253001
RPL27A ribosomal protein L27a -0.0252721
RPL11 ribosomal protein L11 -0.0252077
RPS24 ribosomal protein S24 -0.0249995
ATXN1 ataxin 1 -0.0247313
SLC38A2 solute carrier family 38, member 2 -0.0243539
PSD3 pleckstrin and Sec7 domain containing 3 -0.0242666
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0242278
YBX1 Y box binding protein 1 -0.0242216
RPL13A ribosomal protein L13a -0.024084