| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.129312 |
| ENO1 | enolase 1, (alpha) | 0.106814 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0933491 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0927636 |
| NDRG1 | N-myc downstream regulated 1 | 0.0888317 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0661284 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0651848 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0584679 |
| VEGFA | vascular endothelial growth factor A | 0.0579949 |
| GOLGA4 | golgin A4 | 0.0567561 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0554517 |
| RHOA | ras homolog family member A | 0.0550216 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.054411 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0537965 |
| FAM117B | family with sequence similarity 117, member B | 0.0525798 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0508108 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0483687 |
| FTL | ferritin, light polypeptide | 0.0478514 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0476454 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0462962 |
| MATR3 | matrin 3 | 0.0460926 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0457052 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0422558 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0419868 |
| TPM3 | tropomyosin 3 | 0.0418697 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0412625 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.041194 |
| RPS6 | ribosomal protein S6 | 0.0409956 |
| INSIG2 | insulin induced gene 2 | 0.0405179 |
| TXNIP | thioredoxin interacting protein | 0.0404219 |
| TXNRD1 | thioredoxin reductase 1 | 0.03995 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0397147 |
| RPL11 | ribosomal protein L11 | 0.0394361 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0391998 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0382279 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.037928 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0375745 |
| CCDC186 | coiled-coil domain containing 186 | 0.0359206 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0356693 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0336803 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0335241 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0332875 |
| ANXA2 | annexin A2 | 0.0326544 |
| LDHA | lactate dehydrogenase A | 0.0314125 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0313117 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0304801 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0304667 |
| RPL26 | ribosomal protein L26 | 0.0300875 |
| YBX1 | Y box binding protein 1 | 0.0295141 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0293695 |
| RPS18 | ribosomal protein S18 | 0.0292011 |
| RNF24 | ring finger protein 24 | 0.0291604 |
| SFTPA2 | surfactant protein A2 | 0.028855 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0288179 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0287218 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0280965 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0280961 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0278238 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0277378 |
| PHF3 | PHD finger protein 3 | 0.0276543 |
| RPL7 | ribosomal protein L7 | 0.0275319 |
| RPS3 | ribosomal protein S3 | 0.0275276 |
| RLF | rearranged L-myc fusion | 0.027487 |
| RPL37A | ribosomal protein L37a | 0.026808 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0266547 |
| BRD4 | bromodomain containing 4 | 0.0263565 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0261964 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0261666 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0260819 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0257403 |
| FAM162A | family with sequence similarity 162, member A | 0.025722 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0253665 |
| RIOK3 | RIO kinase 3 | 0.0249527 |
| RPL3 | ribosomal protein L3 | 0.0249467 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0248888 |
| SSR1 | signal sequence receptor, alpha | 0.0248813 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0247634 |
| RPS27 | ribosomal protein S27 | 0.0246673 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0244489 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0242937 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0241284 |
| THOC2 | THO complex 2 | 0.0240162 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.0239863 |
| CCNG2 | cyclin G2 | 0.0238062 |
| SQSTM1 | sequestosome 1 | 0.023738 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.02341 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0232984 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0231583 |
| ZNF292 | zinc finger protein 292 | 0.0230657 |
| UBXN7 | UBX domain protein 7 | 0.0230085 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0229903 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0229513 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0226646 |
| WDR45B | WD repeat domain 45B | 0.0225406 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0224283 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0224095 |
| RPS13 | ribosomal protein S13 | 0.0222803 |
| TMF1 | TATA element modulatory factor 1 | 0.0221638 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | 0.0220145 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | 0.0218218 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.188754 |
| FAT1 | FAT atypical cadherin 1 | -0.153589 |
| AHNAK | AHNAK nucleoprotein | -0.121899 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.116048 |
| RAD51B | RAD51 paralog B | -0.105704 |
| TMSB10 | thymosin beta 10 | -0.103154 |
| INTS6 | integrator complex subunit 6 | -0.0937515 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0874671 |
| SERINC5 | serine incorporator 5 | -0.0869742 |
| VCL | vinculin | -0.0797253 |
| MKI67 | marker of proliferation Ki-67 | -0.0732447 |
| PRELID2 | PRELI domain containing 2 | -0.072397 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0689773 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0688953 |
| DIAPH3 | diaphanous-related formin 3 | -0.0596581 |
| MSI2 | musashi RNA-binding protein 2 | -0.0555016 |
| FHIT | fragile histidine triad | -0.0531849 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.0497681 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0482039 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0469119 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0463279 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0455221 |
| EGR1 | early growth response 1 | -0.045178 |
| HOXB3 | homeobox B3 | -0.044588 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0438679 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0424203 |
| GNAS | GNAS complex locus | -0.0422468 |
| CTBP2 | C-terminal binding protein 2 | -0.0421841 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0418701 |
| PKM | pyruvate kinase, muscle | -0.0418203 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0410191 |
| EHBP1 | EH domain binding protein 1 | -0.0408655 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0407971 |
| HMGA2 | high mobility group AT-hook 2 | -0.0403311 |
| CENPF | centromere protein F, 350/400kDa | -0.0401437 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0370817 |
| FNDC3B | fibronectin type III domain containing 3B | -0.036795 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0367167 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0366906 |
| GPHN | gephyrin | -0.0357675 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0356077 |
| MED13L | mediator complex subunit 13-like | -0.0354463 |
| KRT8 | keratin 8, type II | -0.03544 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0344624 |
| MCL1 | myeloid cell leukemia 1 | -0.034411 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0343977 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.033715 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0330647 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0328587 |
| SBF2 | SET binding factor 2 | -0.0327769 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0324427 |
| CLTC | clathrin, heavy chain (Hc) | -0.0323157 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0322502 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0320835 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0318605 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0314332 |
| FLNB | filamin B, beta | -0.0313327 |
| NFIB | nuclear factor I/B | -0.0310841 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0310669 |
| LRRC23 | leucine rich repeat containing 23 | -0.0310187 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0305072 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0302378 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0301545 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0296953 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0296679 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0295172 |
| WWOX | WW domain containing oxidoreductase | -0.0295004 |
| TUBB | tubulin, beta class I | -0.0291288 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0288033 |
| USP34 | ubiquitin specific peptidase 34 | -0.0287885 |
| ZNF518A | zinc finger protein 518A | -0.0287305 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0286736 |
| RBM25 | RNA binding motif protein 25 | -0.0284707 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0283079 |
| RPS21 | ribosomal protein S21 | -0.0281569 |
| ADD3 | adducin 3 (gamma) | -0.0280251 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0279713 |
| SHROOM3 | shroom family member 3 | -0.027565 |
| RNF43 | ring finger protein 43 | -0.0274861 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.02744 |
| LASP1 | LIM and SH3 protein 1 | -0.0273586 |
| HMGB1 | high mobility group box 1 | -0.0271666 |
| NSD3 | nuclear receptor binding SET domain protein 3 | -0.0271481 |
| POU2F1 | POU class 2 homeobox 1 | -0.0270889 |
| CADPS | Ca++-dependent secretion activator | -0.0270423 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0267856 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0266564 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0265539 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0259421 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0259186 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0258987 |
| CFAP44 | cilia and flagella associated protein 44 | -0.0251748 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0251746 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0251497 |
| UBAP2 | ubiquitin associated protein 2 | -0.0251366 |
| FARP2 | FERM, RhoGEF and pleckstrin domain protein 2 | -0.0249626 |
| R3HDM2 | R3H domain containing 2 | -0.0248477 |
| H1-0 | H1.0 linker histone | -0.0248199 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0247627 |
| DMXL1 | Dmx-like 1 | -0.024744 |
