| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.148956 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.130544 |
| B2M | beta-2-microglobulin | 0.108581 |
| MATR3 | matrin 3 | 0.0995453 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0931512 |
| APP | amyloid beta (A4) precursor protein | 0.0724658 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0716273 |
| GOLGA4 | golgin A4 | 0.0694706 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0694419 |
| SET | SET nuclear proto-oncogene | 0.0629941 |
| ZNF292 | zinc finger protein 292 | 0.0626776 |
| TMSB4X | thymosin beta 4, X-linked | 0.0622501 |
| ENO1 | enolase 1, (alpha) | 0.0598837 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0598175 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0583777 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0575049 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0568652 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0515572 |
| RPS6 | ribosomal protein S6 | 0.0513301 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0503069 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0494179 |
| YBX1 | Y box binding protein 1 | 0.0487334 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0485015 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0481377 |
| KIF5B | kinesin family member 5B | 0.0475009 |
| RPL26 | ribosomal protein L26 | 0.0472284 |
| DSPP | dentin sialophosphoprotein | 0.0469088 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0460757 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0459952 |
| RPS2 | ribosomal protein S2 | 0.0453359 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0438399 |
| LAMB3 | laminin, beta 3 | 0.0432081 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0429619 |
| H1-0 | H1.0 linker histone | 0.0428231 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0426801 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0425193 |
| LAMC2 | laminin, gamma 2 | 0.0419366 |
| CALR | calreticulin | 0.0417553 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0413203 |
| CANX | calnexin | 0.0412415 |
| TPM3 | tropomyosin 3 | 0.039866 |
| RNF145 | ring finger protein 145 | 0.0377733 |
| RLF | rearranged L-myc fusion | 0.0374277 |
| RPL11 | ribosomal protein L11 | 0.0369968 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.03608 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0357651 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.035469 |
| RACK1 | receptor for activated C kinase 1 | 0.0350469 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.034954 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0346311 |
| PTK2 | protein tyrosine kinase 2 | 0.0345553 |
| RPL14 | ribosomal protein L14 | 0.0340485 |
| RPL12 | ribosomal protein L12 | 0.0340391 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0335923 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0334616 |
| HELZ | helicase with zinc finger | 0.0326386 |
| TPR | translocated promoter region, nuclear basket protein | 0.0326238 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0323319 |
| PNN | pinin, desmosome associated protein | 0.0322707 |
| RIOK3 | RIO kinase 3 | 0.0319993 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0318475 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.031521 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0314861 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.031268 |
| EPCAM | epithelial cell adhesion molecule | 0.0312037 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0311212 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0308097 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.030494 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0302877 |
| RPS3 | ribosomal protein S3 | 0.0302365 |
| VMP1 | vacuole membrane protein 1 | 0.0302141 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.029835 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.029806 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.0297171 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0294637 |
| JMJD1C | jumonji domain containing 1C | 0.0294635 |
| RPL3 | ribosomal protein L3 | 0.0291365 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0290583 |
| SNX9 | sorting nexin 9 | 0.0288208 |
| RAD21 | RAD21 homolog (S. pombe) | 0.028749 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0285224 |
| SETD2 | SET domain containing 2 | 0.0284232 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0283524 |
| LAMA4 | laminin, alpha 4 | 0.0280623 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.027757 |
| FAT1 | FAT atypical cadherin 1 | 0.0275326 |
| DIAPH1 | diaphanous-related formin 1 | 0.0274431 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0272889 |
| MKI67 | marker of proliferation Ki-67 | 0.0272587 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0271133 |
| SMYD3 | SET and MYND domain containing 3 | 0.0267361 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0264526 |
| TMF1 | TATA element modulatory factor 1 | 0.0263862 |
| YTHDC1 | YTH domain containing 1 | 0.0259979 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0258499 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0258253 |
| DSG2 | desmoglein 2 | 0.0257617 |
| SMAD3 | SMAD family member 3 | 0.0257191 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0255107 |
| ATF4 | activating transcription factor 4 | 0.0254163 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.133356 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0909464 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0858651 |
| NDRG1 | N-myc downstream regulated 1 | -0.0822794 |
| ITGB8 | integrin, beta 8 | -0.0705959 |
| PAX8 | paired box 8 | -0.0695636 |
| ASPH | aspartate beta-hydroxylase | -0.0680629 |
| INTS6 | integrator complex subunit 6 | -0.0679399 |
| EGFR | epidermal growth factor receptor | -0.0603484 |
| MT2A | metallothionein 2A | -0.0592174 |
| HMGA1 | high mobility group AT-hook 1 | -0.0587313 |
| FLNB | filamin B, beta | -0.0582809 |
| HMGA2 | high mobility group AT-hook 2 | -0.0569503 |
| FTL | ferritin, light polypeptide | -0.0551495 |
| CCND1 | cyclin D1 | -0.0533935 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0506085 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0495658 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0492709 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0465607 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0463096 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0461327 |
| SVIL | supervillin | -0.0450003 |
| POTEF | POTE ankyrin domain family, member F | -0.0438543 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0424323 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0415851 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0412136 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0406006 |
| PKM | pyruvate kinase, muscle | -0.0404265 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0390505 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0389983 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0380933 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0376647 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0370426 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0348999 |
| ACTN4 | actinin, alpha 4 | -0.034557 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0340014 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0332117 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0331971 |
| KRT86 | keratin 86, type II | -0.0326126 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0324418 |
| CD44 | CD44 molecule (Indian blood group) | -0.0317054 |
| SNX14 | sorting nexin 14 | -0.0316662 |
| KRT7 | keratin 7, type II | -0.0312224 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.0308795 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0303488 |
| CTBP2 | C-terminal binding protein 2 | -0.0300955 |
| CCDC138 | coiled-coil domain containing 138 | -0.0297586 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0296627 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0291209 |
| SCFD1 | sec1 family domain containing 1 | -0.029047 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0290403 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0289148 |
| UBAP2 | ubiquitin associated protein 2 | -0.0285262 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0285189 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.027674 |
| CMIP | c-Maf inducing protein | -0.0276341 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0274918 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0271998 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0270374 |
| PFN1 | profilin 1 | -0.0266035 |
| FNIP1 | folliculin interacting protein 1 | -0.0265801 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | -0.0259787 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0259712 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0257937 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.0257529 |
| RPS11 | ribosomal protein S11 | -0.0256255 |
| NLK | nemo-like kinase | -0.0253672 |
| AEBP2 | AE binding protein 2 | -0.0253175 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0251266 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0249205 |
| ERBIN | erbb2 interacting protein | -0.0247758 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | -0.0245946 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.024473 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0242758 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0241496 |
| RPL31 | ribosomal protein L31 | -0.0235075 |
| RNF213 | ring finger protein 213 | -0.0230068 |
| PCNX4 | pecanex 4 | -0.0229714 |
| TP53 | tumor protein p53 | -0.0229492 |
| RPL32 | ribosomal protein L32 | -0.0225682 |
| NABP1 | nucleic acid binding protein 1 | -0.0225587 |
| RPL35A | ribosomal protein L35a | -0.0225119 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.0225009 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0224563 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0222968 |
| KRT19 | keratin 19, type I | -0.0222447 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0222427 |
| WDR49 | WD repeat domain 49 | -0.02218 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0221091 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0218245 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0218179 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.021755 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0216354 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0215799 |
| RPL23 | ribosomal protein L23 | -0.0214266 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.021404 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0211814 |
| ITGA6 | integrin, alpha 6 | -0.0211195 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0210264 |
| DNAJC9 | DnaJ (Hsp40) homolog, subfamily C, member 9 | -0.0208371 |
