| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | 0.189895 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.1469 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.137145 |
| VEGFA | vascular endothelial growth factor A | 0.120663 |
| MT2A | metallothionein 2A | 0.0901188 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0896319 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0867546 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0834843 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0791124 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0787979 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.067399 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0667288 |
| AXL | AXL receptor tyrosine kinase | 0.0656804 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0632713 |
| RPS6 | ribosomal protein S6 | 0.0582729 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0553991 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.054834 |
| NDRG1 | N-myc downstream regulated 1 | 0.0545958 |
| MSN | moesin | 0.0528453 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0521348 |
| NAV2 | neuron navigator 2 | 0.0518569 |
| MAP1B | microtubule-associated protein 1B | 0.0516115 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.050874 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0491211 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0463892 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.045575 |
| MLPH | melanophilin | 0.0439304 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0426335 |
| MYO10 | myosin X | 0.0420933 |
| TPM3 | tropomyosin 3 | 0.0395265 |
| STC1 | stanniocalcin 1 | 0.0371057 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0361682 |
| SMAD3 | SMAD family member 3 | 0.0354069 |
| ENO1 | enolase 1, (alpha) | 0.0349697 |
| NAV1 | neuron navigator 1 | 0.0347303 |
| CDCP1 | CUB domain containing protein 1 | 0.0343558 |
| FAM13A | family with sequence similarity 13, member A | 0.0340285 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0339861 |
| SEPTIN9 | septin 9 | 0.0337166 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0335257 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0334461 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.033026 |
| RRM2 | ribonucleotide reductase M2 | 0.0329493 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0329296 |
| DTNA | dystrobrevin, alpha | 0.0324614 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0319971 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0315834 |
| LOXL2 | lysyl oxidase-like 2 | 0.0315463 |
| PLEC | plectin | 0.0310366 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.030926 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0306741 |
| YBX1 | Y box binding protein 1 | 0.0305249 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0305122 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0303643 |
| RNF145 | ring finger protein 145 | 0.0299079 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0293305 |
| DNMBP | dynamin binding protein | 0.0287589 |
| GPC5 | glypican 5 | 0.0283687 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0278534 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0276294 |
| TNS1 | tensin 1 | 0.0273454 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0272665 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0270389 |
| PTK2 | protein tyrosine kinase 2 | 0.0264677 |
| RND3 | Rho family GTPase 3 | 0.0263537 |
| JAG1 | jagged 1 | 0.0263395 |
| RHBDF2 | rhomboid 5 homolog 2 (Drosophila) | 0.0260589 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0257978 |
| RNF24 | ring finger protein 24 | 0.0257665 |
| WWOX | WW domain containing oxidoreductase | 0.024987 |
| B2M | beta-2-microglobulin | 0.0248794 |
| FOSL1 | FOS-like antigen 1 | 0.0245787 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0245249 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0243313 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0240755 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0239987 |
| CD82 | CD82 molecule | 0.0238521 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0237906 |
| ZNF638 | zinc finger protein 638 | 0.0236597 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0236055 |
| DIAPH1 | diaphanous-related formin 1 | 0.0231894 |
| FAT1 | FAT atypical cadherin 1 | 0.023134 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0231254 |
| RPL12 | ribosomal protein L12 | 0.0228529 |
| ANGPTL4 | angiopoietin-like 4 | 0.0228525 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0227649 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0227252 |
| HELZ | helicase with zinc finger | 0.0225255 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0224295 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0220202 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0217727 |
| CAPRIN2 | caprin family member 2 | 0.0214976 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0214044 |
| VEGFC | vascular endothelial growth factor C | 0.021381 |
| RPL11 | ribosomal protein L11 | 0.02129 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0212767 |
| RPS18 | ribosomal protein S18 | 0.0212524 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0210805 |
| IL11 | interleukin 11 | 0.0210731 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0210304 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.373097 |
| CDH13 | cadherin 13 | -0.190194 |
| VIM | vimentin | -0.14963 |
| TMSB10 | thymosin beta 10 | -0.148946 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.128225 |
| ASPH | aspartate beta-hydroxylase | -0.101565 |
| IGF2 | insulin-like growth factor 2 | -0.101075 |
| HMGA2 | high mobility group AT-hook 2 | -0.0999881 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0995117 |
| PTMA | prothymosin, alpha | -0.0833916 |
| ACTG1 | actin gamma 1 | -0.0820967 |
| EGR1 | early growth response 1 | -0.0800581 |
| TENM2 | teneurin transmembrane protein 2 | -0.0795861 |
| COL1A1 | collagen, type I, alpha 1 | -0.0782917 |
| LOX | lysyl oxidase | -0.0716586 |
| VCL | vinculin | -0.0687281 |
| RAI14 | retinoic acid induced 14 | -0.0678639 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0634045 |
| FMN1 | formin 1 | -0.0626299 |
| PGK1 | phosphoglycerate kinase 1 | -0.0603505 |
| DST | dystonin | -0.0603374 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.055722 |
| CAVIN1 | caveolae associated protein 1 | -0.0528624 |
| RRBP1 | ribosome binding protein 1 | -0.0508736 |
| CCND1 | cyclin D1 | -0.0505633 |
| CANX | calnexin | -0.0499349 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0498036 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0472932 |
| GLIS3 | GLIS family zinc finger 3 | -0.047148 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0469943 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0462376 |
| TNNC1 | troponin C type 1 (slow) | -0.0445463 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0444946 |
| HDLBP | high density lipoprotein binding protein | -0.0422388 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0399881 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0397615 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0393977 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.038796 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0385145 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0371137 |
| TMEM263 | transmembrane protein 263 | -0.0367771 |
| IER3 | immediate early response 3 | -0.0363851 |
| PCBP3 | poly(rC) binding protein 3 | -0.0360657 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0359466 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0350783 |
| SBF2 | SET binding factor 2 | -0.0346848 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0337018 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0336961 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0336244 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.033584 |
| NABP1 | nucleic acid binding protein 1 | -0.0335227 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0324275 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0319472 |
| GNAS | GNAS complex locus | -0.0315729 |
| NF1 | neurofibromin 1 | -0.0313528 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0305924 |
| RAD51B | RAD51 paralog B | -0.0305013 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0303047 |
| FSTL1 | follistatin-like 1 | -0.0300876 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0299736 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0289594 |
| EHBP1 | EH domain binding protein 1 | -0.028782 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0287307 |
| GLG1 | golgi glycoprotein 1 | -0.0287184 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0284614 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.028205 |
| DNAAF9 | dynein axonemal assembly factor 9 | -0.0279418 |
| CUX1 | cut-like homeobox 1 | -0.0279207 |
| CALU | calumenin | -0.0274916 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0273494 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0272917 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.0272403 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.027217 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0272118 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0270871 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.026881 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0268536 |
| OSMR | oncostatin M receptor | -0.0267069 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0265442 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0265175 |
| RIN2 | Ras and Rab interactor 2 | -0.0263002 |
| MEF2A | myocyte enhancer factor 2A | -0.0260668 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0259271 |
| TAOK1 | TAO kinase 1 | -0.025789 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0254139 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0253735 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0252679 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0251495 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.025134 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0247489 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0245706 |
| IL1B | interleukin 1, beta | -0.0242926 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0242128 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0240502 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0238603 |
| PCNX4 | pecanex 4 | -0.0238402 |
| THBS1 | thrombospondin 1 | -0.0236654 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.02361 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0232563 |
| CDK14 | cyclin-dependent kinase 14 | -0.0225371 |
