| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.386249 |
| VEGFA | vascular endothelial growth factor A | 0.167255 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.128859 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.1069 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0800535 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.073334 |
| CALR | calreticulin | 0.0615562 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0549758 |
| CDH13 | cadherin 13 | 0.053978 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0510641 |
| LOXL2 | lysyl oxidase-like 2 | 0.048477 |
| DOCK5 | dedicator of cytokinesis 5 | 0.046756 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0417419 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0402507 |
| ENO1 | enolase 1, (alpha) | 0.0365225 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0353275 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0341731 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0332581 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0326614 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0314218 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0314198 |
| RPS6 | ribosomal protein S6 | 0.030899 |
| EFNA5 | ephrin-A5 | 0.0308944 |
| EGFR | epidermal growth factor receptor | 0.0307916 |
| CLMP | CXADR-like membrane protein | 0.0298199 |
| MATR3 | matrin 3 | 0.0295022 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0291115 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0287991 |
| PLEC | plectin | 0.0285205 |
| HMGA2 | high mobility group AT-hook 2 | 0.0284295 |
| COL5A1 | collagen, type V, alpha 1 | 0.0278838 |
| FMNL2 | formin-like 2 | 0.0276222 |
| ARRDC3 | arrestin domain containing 3 | 0.0257316 |
| PDE10A | phosphodiesterase 10A | 0.0254484 |
| APP | amyloid beta (A4) precursor protein | 0.0250926 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.025076 |
| MED13L | mediator complex subunit 13-like | 0.0242615 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0242357 |
| PTK2 | protein tyrosine kinase 2 | 0.0241478 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0237086 |
| KIF5B | kinesin family member 5B | 0.0229689 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0224052 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0222333 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0219682 |
| AHNAK | AHNAK nucleoprotein | 0.0212161 |
| RPS3 | ribosomal protein S3 | 0.0211439 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0208483 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0205509 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0204252 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0203631 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0200585 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0200534 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0198465 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0196791 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0195313 |
| TPM3 | tropomyosin 3 | 0.0191588 |
| RNF145 | ring finger protein 145 | 0.0191519 |
| MSN | moesin | 0.019111 |
| YBX1 | Y box binding protein 1 | 0.0189505 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0187341 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0186489 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0184725 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0183919 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0183892 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0181563 |
| CADM1 | cell adhesion molecule 1 | 0.0173924 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0172436 |
| TNS1 | tensin 1 | 0.0171996 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0171908 |
| DIAPH1 | diaphanous-related formin 1 | 0.0170197 |
| RHOA | ras homolog family member A | 0.0169565 |
| AXL | AXL receptor tyrosine kinase | 0.0169431 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0168771 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.01645 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0163279 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0161991 |
| ZNF638 | zinc finger protein 638 | 0.0160302 |
| AAK1 | AP2 associated kinase 1 | 0.0158877 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0157012 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0155764 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0154135 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0153077 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.01529 |
| RTN4 | reticulon 4 | 0.0152635 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0151732 |
| TAOK1 | TAO kinase 1 | 0.0150849 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0150176 |
| CARS1 | cysteinyl-tRNA synthetase 1 | 0.0149675 |
| NOTCH2 | notch 2 | 0.0146567 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0146564 |
| ANO10 | anoctamin 10 | 0.0146148 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0144822 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0144347 |
| JUN | jun proto-oncogene | 0.014382 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0143695 |
| CCNY | cyclin Y | 0.0143279 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0142286 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0141846 |
| RPS18 | ribosomal protein S18 | 0.0141836 |
| ANXA5 | annexin A5 | 0.014131 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.188359 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.173418 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.156 |
| FN1 | fibronectin 1 | -0.151732 |
| TMSB10 | thymosin beta 10 | -0.138782 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.116859 |
| COL1A2 | collagen, type I, alpha 2 | -0.107247 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0847845 |
| INHBA | inhibin, beta A | -0.0807401 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0737848 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0644067 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0629274 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0627051 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0616086 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0607326 |
| VIM | vimentin | -0.0529513 |
| POSTN | periostin, osteoblast specific factor | -0.0522165 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0505879 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0503752 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0485822 |
| IL6ST | interleukin 6 signal transducer | -0.0479249 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0475284 |
| DPYD | dihydropyrimidine dehydrogenase | -0.047319 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0472193 |
| LOX | lysyl oxidase | -0.0466816 |
| RIGI | RNA sensor RIG-I | -0.0459645 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.044951 |
| PRELID2 | PRELI domain containing 2 | -0.042076 |
| OSMR | oncostatin M receptor | -0.0418402 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0409079 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0401503 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0394611 |
| VCAN | versican | -0.0392424 |
| EGR1 | early growth response 1 | -0.0374373 |
| VCL | vinculin | -0.0370088 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.036761 |
| MT1X | metallothionein 1X | -0.035584 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0345107 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0333566 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0333208 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.032899 |
| PFN1 | profilin 1 | -0.0322686 |
| ASPH | aspartate beta-hydroxylase | -0.0315501 |
| CALD1 | caldesmon 1 | -0.0315275 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0315012 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.03144 |
| HLA-B | major histocompatibility complex, class I, B | -0.0313301 |
| MT2A | metallothionein 2A | -0.0306329 |
| ACTG1 | actin gamma 1 | -0.0300517 |
| FTL | ferritin, light polypeptide | -0.0286725 |
| IER3 | immediate early response 3 | -0.0285512 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0280148 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.027935 |
| CNTN5 | contactin 5 | -0.0274626 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0271651 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0266918 |
| KLF6 | Kruppel-like factor 6 | -0.0266565 |
| SP100 | SP100 nuclear antigen | -0.0263852 |
| COL3A1 | collagen, type III, alpha 1 | -0.0257248 |
| TAPBP | TAP binding protein (tapasin) | -0.0255228 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0251923 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0251622 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0248694 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0247585 |
| GNAS | GNAS complex locus | -0.0241379 |
| MX2 | MX dynamin-like GTPase 2 | -0.0237009 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0235472 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.023504 |
| HMGA1 | high mobility group AT-hook 1 | -0.0233916 |
| STC1 | stanniocalcin 1 | -0.0233159 |
| S100A6 | S100 calcium binding protein A6 | -0.0230065 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0229312 |
| LMNA | lamin A/C | -0.0229198 |
| TAGLN2 | transgelin 2 | -0.0227838 |
| TPM4 | tropomyosin 4 | -0.0227324 |
| NRP1 | neuropilin 1 | -0.0227072 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0220754 |
| PALLD | palladin, cytoskeletal associated protein | -0.0218308 |
| FBN1 | fibrillin 1 | -0.0215992 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0206207 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0204292 |
| PGK1 | phosphoglycerate kinase 1 | -0.0201519 |
| PLSCR1 | phospholipid scramblase 1 | -0.0201106 |
| TUBB | tubulin, beta class I | -0.0198282 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0194578 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0193315 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0193073 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0189975 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.018963 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0189397 |
| GBP1 | guanylate binding protein 1, interferon-inducible | -0.0187488 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0187172 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0184661 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0184092 |
| RPL35A | ribosomal protein L35a | -0.0184082 |
| MAP1B | microtubule-associated protein 1B | -0.0182298 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.018224 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0181394 |
| RPS21 | ribosomal protein S21 | -0.0180353 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0180248 |
