| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.242004 |
| NDRG1 | N-myc downstream regulated 1 | 0.12641 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.116032 |
| VEGFA | vascular endothelial growth factor A | 0.0997549 |
| KRT18 | keratin 18, type I | 0.0804185 |
| LMO7 | LIM domain 7 | 0.0634187 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0597177 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0578554 |
| FAM13A | family with sequence similarity 13, member A | 0.0554102 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0444701 |
| BCL2L1 | BCL2-like 1 | 0.0432661 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0429141 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0428925 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0408637 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0399 |
| RPS6 | ribosomal protein S6 | 0.0388891 |
| FRY | furry homolog (Drosophila) | 0.0377861 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0353023 |
| KRT20 | keratin 20, type I | 0.0351433 |
| PCED1B | PC-esterase domain containing 1B | 0.0343828 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0331264 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.03213 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0317615 |
| TMEM45B | transmembrane protein 45B | 0.0307609 |
| DNM2 | dynamin 2 | 0.0289259 |
| DSPP | dentin sialophosphoprotein | 0.0288594 |
| KRT19 | keratin 19, type I | 0.028799 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0271466 |
| FOXP1 | forkhead box P1 | 0.027091 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0264768 |
| ANXA11 | annexin A11 | 0.0251692 |
| TNS1 | tensin 1 | 0.0248179 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0242986 |
| TJP2 | tight junction protein 2 | 0.0242104 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0220724 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0220701 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0218449 |
| CLMN | calmin (calponin-like, transmembrane) | 0.0218255 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0217182 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.021164 |
| BPTF | bromodomain PHD finger transcription factor | 0.0209927 |
| CA12 | carbonic anhydrase XII | 0.0204634 |
| CCNY | cyclin Y | 0.0202534 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0201673 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0201059 |
| TM4SF4 | transmembrane 4 L six family member 4 | 0.0200946 |
| PRELID2 | PRELI domain containing 2 | 0.019928 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0198829 |
| RIN2 | Ras and Rab interactor 2 | 0.0196717 |
| ARHGAP23 | Rho GTPase activating protein 23 | 0.0196236 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0190007 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0188334 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0187855 |
| MYO5B | myosin VB | 0.0187432 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0183205 |
| SEPTIN9 | septin 9 | 0.0183058 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0180964 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0180303 |
| RAD51B | RAD51 paralog B | 0.0180077 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0179092 |
| CUX1 | cut-like homeobox 1 | 0.0173981 |
| MGLL | monoglyceride lipase | 0.0173558 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0170062 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0169021 |
| LIPH | lipase, member H | 0.0167648 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0165862 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0164434 |
| ITPKC | inositol-trisphosphate 3-kinase C | 0.0163739 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.016307 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.0162546 |
| LRP5 | low density lipoprotein receptor-related protein 5 | 0.0159043 |
| ECE1 | endothelin converting enzyme 1 | 0.0157798 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | 0.0157121 |
| SLK | STE20-like kinase | 0.0156023 |
| NECTIN2 | nectin cell adhesion molecule 2 | 0.0155423 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.0154305 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | 0.0154227 |
| MEIS2 | Meis homeobox 2 | 0.0152992 |
| PPL | periplakin | 0.0152455 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0151171 |
| LYZ | lysozyme | 0.0150662 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0149888 |
| TGFA | transforming growth factor, alpha | 0.0149748 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0146454 |
| FA2H | fatty acid 2-hydroxylase | 0.0145928 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0145876 |
| CLIC5 | chloride intracellular channel 5 | 0.0145677 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0144837 |
| ABHD2 | abhydrolase domain containing 2 | 0.0144192 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0144175 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0143359 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0141856 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0141798 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.0140784 |
| SULF2 | sulfatase 2 | 0.0140619 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0138103 |
| CLMB | calcimembrin | 0.0137516 |
| KIF16B | kinesin family member 16B | 0.0136844 |
| ZFHX3 | zinc finger homeobox 3 | 0.0135793 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0134647 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.155612 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.143632 |
| UBC | ubiquitin C | -0.121279 |
| RPL23 | ribosomal protein L23 | -0.106604 |
| PTMA | prothymosin, alpha | -0.104461 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0984994 |
| RPS27A | ribosomal protein S27a | -0.0809665 |
| FTL | ferritin, light polypeptide | -0.0786261 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0768298 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0750499 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.07374 |
| TMSB10 | thymosin beta 10 | -0.0735863 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0677058 |
| TXNRD1 | thioredoxin reductase 1 | -0.0662902 |
| PCBP2 | poly(rC) binding protein 2 | -0.0621294 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0617884 |
| ACTN4 | actinin, alpha 4 | -0.0615117 |
| INTS6 | integrator complex subunit 6 | -0.060981 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0595227 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0589215 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0585416 |
| VCL | vinculin | -0.0567014 |
| TOP1 | topoisomerase (DNA) I | -0.0502963 |
| RPS19 | ribosomal protein S19 | -0.0499022 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0487578 |
| RBM39 | RNA binding motif protein 39 | -0.0475606 |
| OGA | O-GlcNAcase | -0.047499 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0473308 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0469144 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0460521 |
| CANX | calnexin | -0.0454296 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0445062 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0443691 |
| MCL1 | myeloid cell leukemia 1 | -0.0433886 |
| RPLP2 | ribosomal protein, large, P2 | -0.0430988 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0426954 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0426372 |
| RPL18 | ribosomal protein L18 | -0.0424077 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0422784 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0410571 |
| RPS3 | ribosomal protein S3 | -0.0401028 |
| ACTG1 | actin gamma 1 | -0.0394438 |
| RPS5 | ribosomal protein S5 | -0.0394023 |
| RPS24 | ribosomal protein S24 | -0.0375306 |
| SQSTM1 | sequestosome 1 | -0.0373623 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0372967 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0371125 |
| RPS8 | ribosomal protein S8 | -0.0370498 |
| CALR | calreticulin | -0.0366837 |
| COG5 | component of oligomeric golgi complex 5 | -0.0366379 |
| RPS12 | ribosomal protein S12 | -0.0362223 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0362073 |
| RPS21 | ribosomal protein S21 | -0.0358997 |
| ANXA2 | annexin A2 | -0.0348573 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | -0.0346343 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0343283 |
| RPS11 | ribosomal protein S11 | -0.0342031 |
| HYOU1 | hypoxia up-regulated 1 | -0.034106 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0340091 |
| TJP1 | tight junction protein 1 | -0.0335867 |
| RPL9 | ribosomal protein L9 | -0.0334518 |
| RHEB | Ras homolog enriched in brain | -0.0334178 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0329778 |
| RPS16 | ribosomal protein S16 | -0.0325743 |
| RPLP1 | ribosomal protein, large, P1 | -0.0325732 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0324449 |
| RPL5 | ribosomal protein L5 | -0.031677 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0316096 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0313833 |
| SPAG9 | sperm associated antigen 9 | -0.0312779 |
| RPL28 | ribosomal protein L28 | -0.0312398 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0312177 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0308749 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0307411 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0306513 |
| VMP1 | vacuole membrane protein 1 | -0.0306435 |
| RPL27A | ribosomal protein L27a | -0.0303441 |
| DIAPH3 | diaphanous-related formin 3 | -0.0301202 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0300064 |
| ENO1 | enolase 1, (alpha) | -0.0298694 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0298099 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0297659 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.029556 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0294647 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0293711 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0292769 |
| RPS13 | ribosomal protein S13 | -0.0289159 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0283298 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0282551 |
| RPL19 | ribosomal protein L19 | -0.0281446 |
| ZNF207 | zinc finger protein 207 | -0.027922 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0278578 |
| TES | testin LIM domain protein | -0.0277394 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0275305 |
| PDZD8 | PDZ domain containing 8 | -0.0274958 |
| RPL12 | ribosomal protein L12 | -0.0273813 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0273624 |
| RPL37A | ribosomal protein L37a | -0.0271036 |
| SDCBP | syndecan binding protein (syntenin) | -0.0270492 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0267619 |
