| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tofacitinib (citrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.143472 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.110624 |
| FN1 | fibronectin 1 | 0.109804 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.105194 |
| DSPP | dentin sialophosphoprotein | 0.102957 |
| ENO1 | enolase 1, (alpha) | 0.0935628 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0756879 |
| C3 | complement component 3 | 0.0717203 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0676681 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0651602 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0646623 |
| VMP1 | vacuole membrane protein 1 | 0.0626756 |
| TNS1 | tensin 1 | 0.0616526 |
| PEG3 | paternally expressed 3 | 0.0605818 |
| VEGFA | vascular endothelial growth factor A | 0.0554076 |
| TF | transferrin | 0.054983 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.053657 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0520702 |
| SVIL | supervillin | 0.0513272 |
| FAT1 | FAT atypical cadherin 1 | 0.0503083 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0481183 |
| JMJD1C | jumonji domain containing 1C | 0.0477891 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0458891 |
| BCL2L1 | BCL2-like 1 | 0.0454165 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0450983 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0448057 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0445542 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0420699 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0416668 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0409423 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0395708 |
| FRMD5 | FERM domain containing 5 | 0.03941 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0392262 |
| EHBP1 | EH domain binding protein 1 | 0.0391472 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0341129 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.033999 |
| CTSB | cathepsin B | 0.0336123 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0318718 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0312137 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.0299203 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0296891 |
| CCNY | cyclin Y | 0.0294356 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0293076 |
| FERMT1 | fermitin family member 1 | 0.0292012 |
| PKP4 | plakophilin 4 | 0.0290766 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0289821 |
| RPS18 | ribosomal protein S18 | 0.0285307 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.028262 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0281084 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.027797 |
| SEPTIN9 | septin 9 | 0.0273152 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0270921 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | 0.026897 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0265829 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0261363 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0257589 |
| ATP10A | ATPase, class V, type 10A | 0.0253814 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0252218 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0251247 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0247855 |
| MATR3 | matrin 3 | 0.024686 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0244346 |
| RAI14 | retinoic acid induced 14 | 0.0244339 |
| YME1L1 | YME1-like 1 ATPase | 0.024428 |
| TMEM41B | transmembrane protein 41B | 0.0243986 |
| TPM4 | tropomyosin 4 | 0.023748 |
| FBXO42 | F-box protein 42 | 0.0235284 |
| RPL26 | ribosomal protein L26 | 0.023089 |
| TPM3 | tropomyosin 3 | 0.0230659 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0226478 |
| ENAH | enabled homolog (Drosophila) | 0.0225495 |
| ANXA5 | annexin A5 | 0.0224241 |
| SMAD3 | SMAD family member 3 | 0.0222966 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0222475 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0221207 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0220523 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0220106 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0219881 |
| TMEM181 | transmembrane protein 181 | 0.021841 |
| CEP250 | centrosomal protein 250kDa | 0.0214321 |
| RIN2 | Ras and Rab interactor 2 | 0.0212789 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0212127 |
| ITGB5 | integrin, beta 5 | 0.0210789 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0208906 |
| OPTN | optineurin | 0.0208074 |
| MTSS1 | metastasis suppressor 1 | 0.0207495 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0205084 |
| TCIM | transcriptional and immune response regulator | 0.0204293 |
| RUNX1 | runt-related transcription factor 1 | 0.019995 |
| ARFGEF3 | ARFGEF family member 3 | 0.019718 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0195015 |
| YAP1 | Yes-associated protein 1 | 0.0194527 |
| HLF | hepatic leukemia factor | 0.0193393 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0193393 |
| PLEC | plectin | 0.0192803 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0191474 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0189875 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0189603 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0188256 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0187821 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.242876 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.149795 |
| APOA2 | apolipoprotein A-II | -0.115077 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.102948 |
| MT2A | metallothionein 2A | -0.0993178 |
| TMSB10 | thymosin beta 10 | -0.0834244 |
| APOB | apolipoprotein B | -0.0818958 |
| HMGA1 | high mobility group AT-hook 1 | -0.0781664 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0764896 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0754897 |
| VCL | vinculin | -0.0634618 |
| GPC6 | glypican 6 | -0.0517368 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0508509 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0500304 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0463878 |
| KIF21A | kinesin family member 21A | -0.0461404 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0451609 |
| GNAS | GNAS complex locus | -0.0435841 |
| RPL34 | ribosomal protein L34 | -0.0419603 |
| ASPH | aspartate beta-hydroxylase | -0.0409338 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0378212 |
| PLIN2 | perilipin 2 | -0.0377753 |
| RPS21 | ribosomal protein S21 | -0.0372301 |
| PTCHD4 | patched domain containing 4 | -0.0367179 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0365797 |
| TLE4 | transducin-like enhancer of split 4 | -0.0363537 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0363099 |
| RPL32 | ribosomal protein L32 | -0.0351095 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0342613 |
| RPLP2 | ribosomal protein, large, P2 | -0.0334337 |
| SDC4 | syndecan 4 | -0.0323981 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0323303 |
| GPC3 | glypican 3 | -0.0323199 |
| CP | ceruloplasmin (ferroxidase) | -0.0319372 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0314039 |
| HMGA2 | high mobility group AT-hook 2 | -0.0305817 |
| NPR2 | natriuretic peptide receptor 2 | -0.0303636 |
| RPL35A | ribosomal protein L35a | -0.0299462 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0296908 |
| RNF213 | ring finger protein 213 | -0.0295683 |
| RPL23 | ribosomal protein L23 | -0.0291514 |
| ACTG1 | actin gamma 1 | -0.0288633 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0287487 |
| NABP1 | nucleic acid binding protein 1 | -0.0286583 |
| FHIT | fragile histidine triad | -0.0283576 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0282527 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0278666 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0278659 |
| INTS6 | integrator complex subunit 6 | -0.0271593 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0271195 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.02689 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.026836 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0268354 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0266316 |
| MT1X | metallothionein 1X | -0.0260728 |
| MIDN | midnolin | -0.0259374 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.02564 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0254659 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0252938 |
| RBM39 | RNA binding motif protein 39 | -0.0252804 |
| DTNA | dystrobrevin, alpha | -0.0248532 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.024608 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.024576 |
| EGR1 | early growth response 1 | -0.0243353 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0241499 |
| DENND4A | DENN/MADD domain containing 4A | -0.0240749 |
| FOXO3 | forkhead box O3 | -0.024003 |
| SQSTM1 | sequestosome 1 | -0.0238358 |
| PHF3 | PHD finger protein 3 | -0.023734 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0236158 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0234871 |
| RPS5 | ribosomal protein S5 | -0.02347 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0233696 |
| MAP1B | microtubule-associated protein 1B | -0.0232 |
| FMNL2 | formin-like 2 | -0.0231519 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0231031 |
| RPS24 | ribosomal protein S24 | -0.0230716 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.023036 |
| PALLD | palladin, cytoskeletal associated protein | -0.0228542 |
| S100A9 | S100 calcium binding protein A9 | -0.0226204 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.022615 |
| VCAN | versican | -0.0221193 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0218637 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0218293 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0217664 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0217549 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0217525 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0215602 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0215352 |
| RPS6 | ribosomal protein S6 | -0.0214086 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0213226 |
| THOC2 | THO complex 2 | -0.021237 |
| ZNF804A | zinc finger protein 804A | -0.0209549 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0206869 |
| H1-0 | H1.0 linker histone | -0.0204353 |
| PFN1 | profilin 1 | -0.0203553 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0202234 |
| RPL9 | ribosomal protein L9 | -0.0200226 |
| RBM25 | RNA binding motif protein 25 | -0.0200057 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0199142 |
