| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VEGFA | vascular endothelial growth factor A | 0.107402 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0834931 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0815339 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0558426 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0438032 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0437698 |
| RPL35A | ribosomal protein L35a | 0.0388632 |
| RPS6 | ribosomal protein S6 | 0.0359852 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0355196 |
| FTL | ferritin, light polypeptide | 0.0280736 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0277836 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0268006 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0261173 |
| MT2A | metallothionein 2A | 0.0254574 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0246969 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0230392 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.022741 |
| SNX9 | sorting nexin 9 | 0.0227091 |
| AGR2 | anterior gradient 2 | 0.0220972 |
| TFF1 | trefoil factor 1 | 0.0216755 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0206916 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0206263 |
| RPS29 | ribosomal protein S29 | 0.0198808 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0193532 |
| FN1 | fibronectin 1 | 0.0190589 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.018894 |
| MXI1 | MAX interactor 1, dimerization protein | 0.018106 |
| ATXN1 | ataxin 1 | 0.0172086 |
| CDK13 | cyclin-dependent kinase 13 | 0.0166283 |
| NDRG1 | N-myc downstream regulated 1 | 0.0165578 |
| MT1E | metallothionein 1E | 0.0164919 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0164662 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0162 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0159064 |
| TMSB4X | thymosin beta 4, X-linked | 0.0158575 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0157208 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0155984 |
| PGM3 | phosphoglucomutase 3 | 0.0153505 |
| TMF1 | TATA element modulatory factor 1 | 0.0151455 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0149999 |
| RPS8 | ribosomal protein S8 | 0.014925 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0148083 |
| NEBL | nebulette | 0.0145851 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.0144932 |
| RPL38 | ribosomal protein L38 | 0.0144354 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0142742 |
| RPL7A | ribosomal protein L7a | 0.0141873 |
| GOLGA4 | golgin A4 | 0.0141724 |
| CTSB | cathepsin B | 0.0140025 |
| NUCB2 | nucleobindin 2 | 0.0139429 |
| RHOA | ras homolog family member A | 0.0137596 |
| SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | 0.0137322 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0135914 |
| HM13 | histocompatibility (minor) 13 | 0.0132276 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0131034 |
| GOLGA2 | golgin A2 | 0.012897 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0128783 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0125456 |
| JMJD1C | jumonji domain containing 1C | 0.0124784 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0124463 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0124083 |
| PRKCI | protein kinase C, iota | 0.0124021 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0123262 |
| IGF2 | insulin-like growth factor 2 | 0.0122121 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0121779 |
| SSR1 | signal sequence receptor, alpha | 0.0120775 |
| DDI2 | DNA-damage inducible 1 homolog 2 (S. cerevisiae) | 0.012069 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | 0.0120187 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.011982 |
| ATF4 | activating transcription factor 4 | 0.0119602 |
| NSD3 | nuclear receptor binding SET domain protein 3 | 0.0119481 |
| ANXA5 | annexin A5 | 0.0119366 |
| ICA1 | islet cell autoantigen 1, 69kDa | 0.0119081 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0118959 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0118063 |
| AHI1 | Abelson helper integration site 1 | 0.0118002 |
| VPS53 | vacuolar protein sorting 53 homolog (S. cerevisiae) | 0.0116638 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0116164 |
| FBXO32 | F-box protein 32 | 0.0115366 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.011486 |
| RIGI | RNA sensor RIG-I | 0.0114053 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0111735 |
| EFNA1 | ephrin-A1 | 0.0111143 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0111143 |
| USP36 | ubiquitin specific peptidase 36 | 0.0110407 |
| RPS25 | ribosomal protein S25 | 0.0110196 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0109846 |
| KAZN | kazrin, periplakin interacting protein | 0.0109655 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0108672 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0107979 |
| JMY | junction mediating and regulatory protein, p53 cofactor | 0.0107086 |
| ABHD3 | abhydrolase domain containing 3 | 0.010595 |
| NFX1 | nuclear transcription factor, X-box binding 1 | 0.0105823 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.0104521 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.010409 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0103997 |
| SRP54 | signal recognition particle 54kDa | 0.010393 |
| HOXA9 | homeobox A9 | 0.0101243 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0100944 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0100937 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.191121 |
| TMSB10 | thymosin beta 10 | -0.127066 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.124302 |
| NPSR1 | neuropeptide S receptor 1 | -0.113412 |
| FAT1 | FAT atypical cadherin 1 | -0.0912518 |
| PTMA | prothymosin, alpha | -0.0910038 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0888442 |
| ITGA6 | integrin, alpha 6 | -0.0857287 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0847458 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0817523 |
| VCL | vinculin | -0.0782006 |
| ASPH | aspartate beta-hydroxylase | -0.0723066 |
| ACTN4 | actinin, alpha 4 | -0.0720457 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0682127 |
| FLNB | filamin B, beta | -0.0672162 |
| TNS4 | tensin 4 | -0.0648465 |
| AHNAK | AHNAK nucleoprotein | -0.0633846 |
| KRT8 | keratin 8, type II | -0.0568172 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0562016 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0546562 |
| PKM | pyruvate kinase, muscle | -0.0526722 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0521697 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0512207 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0504654 |
| PRELID2 | PRELI domain containing 2 | -0.0498097 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0490316 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0482401 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0452682 |
| RNF43 | ring finger protein 43 | -0.0450791 |
| FHIT | fragile histidine triad | -0.0448373 |
| SERINC5 | serine incorporator 5 | -0.0447052 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0441654 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0437317 |
| RPL23 | ribosomal protein L23 | -0.0435691 |
| UBC | ubiquitin C | -0.0431455 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0430067 |
| PCBP2 | poly(rC) binding protein 2 | -0.0429791 |
| LAMA4 | laminin, alpha 4 | -0.0422335 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0422188 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0420537 |
| CADPS | Ca++-dependent secretion activator | -0.040753 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0403274 |
| ETV6 | ets variant 6 | -0.0401922 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0400969 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0400252 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0389933 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.0386669 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0381464 |
| AREG | amphiregulin | -0.0373204 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0369442 |
| RPS27A | ribosomal protein S27a | -0.0369322 |
| RPL18 | ribosomal protein L18 | -0.0363123 |
| TRIM2 | tripartite motif containing 2 | -0.0361956 |
| NCOR1 | nuclear receptor corepressor 1 | -0.035838 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0354429 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0354343 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.035299 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0352824 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0349179 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0347798 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0343778 |
| MED13L | mediator complex subunit 13-like | -0.0340938 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0340448 |
| POTEF | POTE ankyrin domain family, member F | -0.0340119 |
| GPHN | gephyrin | -0.0339723 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.033656 |
| HMGA1 | high mobility group AT-hook 1 | -0.0335603 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0334879 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0334001 |
| RAB10 | RAB10, member RAS oncogene family | -0.0333543 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0332051 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0332049 |
| PKP2 | plakophilin 2 | -0.0327576 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.032748 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0326989 |
| RBM39 | RNA binding motif protein 39 | -0.0325872 |
| RPL32 | ribosomal protein L32 | -0.0325567 |
| PGK1 | phosphoglycerate kinase 1 | -0.0325172 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0324703 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0322579 |
| ENO1 | enolase 1, (alpha) | -0.0320715 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0318071 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.031678 |
| ANXA2 | annexin A2 | -0.0316523 |
| NRXN3 | neurexin 3 | -0.0315259 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.031253 |
| PIGR | polymeric immunoglobulin receptor | -0.0308743 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0306871 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0304681 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0304644 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0304461 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | -0.0303046 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0299127 |
| EPCAM | epithelial cell adhesion molecule | -0.0296019 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0294994 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0289229 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0286171 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0285491 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0284826 |
| EHF | ets homologous factor | -0.0279973 |
