| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.116442 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.113917 |
| FAT1 | FAT atypical cadherin 1 | 0.0745984 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0639378 |
| GOLGA4 | golgin A4 | 0.0639008 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0613717 |
| RPS6 | ribosomal protein S6 | 0.0594684 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0506626 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0471079 |
| RACK1 | receptor for activated C kinase 1 | 0.0449662 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0448879 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0429986 |
| VEGFA | vascular endothelial growth factor A | 0.0418983 |
| RPL3 | ribosomal protein L3 | 0.0404477 |
| DSPP | dentin sialophosphoprotein | 0.0393107 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.038391 |
| RPS12 | ribosomal protein S12 | 0.0353266 |
| RPS2 | ribosomal protein S2 | 0.0329827 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0329217 |
| RPS18 | ribosomal protein S18 | 0.0318453 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0312853 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0311535 |
| LMO7 | LIM domain 7 | 0.0309856 |
| ARF4 | ADP-ribosylation factor 4 | 0.0307607 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0307243 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0302489 |
| NDRG1 | N-myc downstream regulated 1 | 0.0299436 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0294891 |
| RNF145 | ring finger protein 145 | 0.0294533 |
| RPS3 | ribosomal protein S3 | 0.0294231 |
| COPA | coatomer protein complex, subunit alpha | 0.0290398 |
| RPL21 | ribosomal protein L21 | 0.0280423 |
| DSCAM | Down syndrome cell adhesion molecule | 0.027628 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0274761 |
| TMF1 | TATA element modulatory factor 1 | 0.0273522 |
| BRD2 | bromodomain containing 2 | 0.026737 |
| PGM3 | phosphoglucomutase 3 | 0.0262047 |
| RPLP0 | ribosomal protein, large, P0 | 0.0255199 |
| MLEC | malectin | 0.0254898 |
| TXNRD1 | thioredoxin reductase 1 | 0.024614 |
| CALU | calumenin | 0.0244355 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0240967 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0234316 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0224313 |
| ABHD2 | abhydrolase domain containing 2 | 0.0220187 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0217973 |
| RPL26 | ribosomal protein L26 | 0.0217399 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0212457 |
| COG6 | component of oligomeric golgi complex 6 | 0.0212301 |
| ARRDC3 | arrestin domain containing 3 | 0.0209127 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0204159 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0204055 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0203915 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0202703 |
| GOLGB1 | golgin B1 | 0.0199045 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0197 |
| SEC24A | SEC24 family member A | 0.0196757 |
| TES | testin LIM domain protein | 0.0195356 |
| UBN2 | ubinuclein 2 | 0.0194029 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.019044 |
| AREG | amphiregulin | 0.0188948 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0187715 |
| SNX9 | sorting nexin 9 | 0.0187696 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0186084 |
| JMY | junction mediating and regulatory protein, p53 cofactor | 0.0185348 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0184846 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0183879 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0183306 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0182766 |
| TXNIP | thioredoxin interacting protein | 0.0182608 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0182096 |
| KIF5B | kinesin family member 5B | 0.0178693 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0176269 |
| YBX1 | Y box binding protein 1 | 0.0176025 |
| EZR | ezrin | 0.0176019 |
| TPM3 | tropomyosin 3 | 0.0175625 |
| SEC24D | SEC24 family member D | 0.0174896 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0174738 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0173838 |
| RPL7 | ribosomal protein L7 | 0.0173301 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.017312 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.0171833 |
| PRRC1 | proline-rich coiled-coil 1 | 0.0170784 |
| RPS17 | ribosomal protein S17 | 0.0169379 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0167733 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0165644 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0163306 |
| SUCO | SUN domain containing ossification factor | 0.01621 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0161906 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0159862 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0159298 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0155071 |
| TBC1D15 | TBC1 domain family, member 15 | 0.0153718 |
| SEC16A | SEC16 homolog A (S. cerevisiae) | 0.0153205 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0153096 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0151349 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0151145 |
| PTEN | phosphatase and tensin homolog | 0.015093 |
| TJP1 | tight junction protein 1 | 0.0148894 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0148818 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.176024 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.167429 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.160016 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0962081 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0934869 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0922217 |
| TMSB10 | thymosin beta 10 | -0.0894605 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0890104 |
| RIGI | RNA sensor RIG-I | -0.0876508 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0867646 |
| MX1 | MX dynamin-like GTPase 1 | -0.0815012 |
| RNF213 | ring finger protein 213 | -0.0805691 |
| SP100 | SP100 nuclear antigen | -0.0791828 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0745203 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0731827 |
| MSI2 | musashi RNA-binding protein 2 | -0.0720539 |
| RAD51B | RAD51 paralog B | -0.0705764 |
| RPLP1 | ribosomal protein, large, P1 | -0.0691891 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0649817 |
| AOPEP | aminopeptidase O (putative) | -0.0636355 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0628487 |
| ACTN4 | actinin, alpha 4 | -0.0620589 |
| PLSCR1 | phospholipid scramblase 1 | -0.0607922 |
| VCL | vinculin | -0.0580663 |
| FHIT | fragile histidine triad | -0.0576215 |
| DENND1A | DENN/MADD domain containing 1A | -0.0573983 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.055885 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0558631 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.0555568 |
| FLNB | filamin B, beta | -0.0541288 |
| XAF1 | XIAP associated factor 1 | -0.0539358 |
| HLA-B | major histocompatibility complex, class I, B | -0.0493251 |
| SERINC5 | serine incorporator 5 | -0.049131 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0490543 |
| ANXA2 | annexin A2 | -0.0489875 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0474157 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.04734 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.046035 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0460236 |
| RPS24 | ribosomal protein S24 | -0.0453911 |
| FRMD5 | FERM domain containing 5 | -0.0451204 |
| PTMA | prothymosin, alpha | -0.0443522 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.044234 |
| SPINK13 | serine peptidase inhibitor, Kazal type 13 (putative) | -0.0442161 |
| DSG3 | desmoglein 3 | -0.0438729 |
| CUX1 | cut-like homeobox 1 | -0.0436548 |
| RBM25 | RNA binding motif protein 25 | -0.0424292 |
| MX2 | MX dynamin-like GTPase 2 | -0.0416802 |
| ACTG1 | actin gamma 1 | -0.0415972 |
| RPL34 | ribosomal protein L34 | -0.0411779 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0411321 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.040637 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0405174 |
| MCU | mitochondrial calcium uniporter | -0.0393374 |
| KRT8 | keratin 8, type II | -0.0387605 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0387274 |
| RPS21 | ribosomal protein S21 | -0.038061 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0375559 |
| FOXP1 | forkhead box P1 | -0.0374137 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.03736 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0370855 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0368075 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0365915 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0360994 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0359971 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.035546 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.035535 |
| EXOC4 | exocyst complex component 4 | -0.0350256 |
| TLN2 | talin 2 | -0.034648 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0344567 |
| RPL35A | ribosomal protein L35a | -0.0343624 |
| MTAP | methylthioadenosine phosphorylase | -0.0335089 |
| PIK3AP1 | phosphoinositide-3-kinase adaptor protein 1 | -0.0332894 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0332064 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.032869 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0328406 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0328379 |
| COBL | cordon-bleu WH2 repeat protein | -0.032818 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0328049 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0327446 |
| PLAC8 | placenta-specific 8 | -0.0323822 |
| FUS | FUS RNA binding protein | -0.0322236 |
| LAMA4 | laminin, alpha 4 | -0.0318015 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0317769 |
| RPL38 | ribosomal protein L38 | -0.0312731 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -0.0312358 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0312336 |
| INTS6 | integrator complex subunit 6 | -0.0310155 |
| DIAPH2 | diaphanous-related formin 2 | -0.0305789 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0305287 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | -0.0305135 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0303657 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0302673 |
| RIMKLB | ribosomal modification protein rimK-like family member B | -0.0301988 |
| IFI44 | interferon-induced protein 44 | -0.0301725 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0297481 |
| NPSR1 | neuropeptide S receptor 1 | -0.0293482 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0291497 |
| RPS19 | ribosomal protein S19 | -0.0289648 |
| PRSS3 | protease, serine, 3 | -0.0286595 |
