| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.262297 |
| CD44 | CD44 molecule (Indian blood group) | 0.199634 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.141465 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.126398 |
| DST | dystonin | 0.120694 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.109318 |
| MT2A | metallothionein 2A | 0.108435 |
| TP63 | tumor protein p63 | 0.0915398 |
| ENO1 | enolase 1, (alpha) | 0.0906681 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0875635 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0854418 |
| CADM2 | cell adhesion molecule 2 | 0.0845977 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0833445 |
| PDE10A | phosphodiesterase 10A | 0.074324 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0729203 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0724205 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0719625 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0701768 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0666501 |
| HDAC9 | histone deacetylase 9 | 0.0652606 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0642906 |
| RUNX1 | runt-related transcription factor 1 | 0.0636703 |
| TSC22D1 | TSC22 domain family, member 1 | 0.062058 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0595612 |
| APP | amyloid beta (A4) precursor protein | 0.0591493 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0574419 |
| RAD51B | RAD51 paralog B | 0.0540054 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0527122 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0513662 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0510065 |
| RNF213 | ring finger protein 213 | 0.0488477 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0485174 |
| CFAP299 | cilia and flagella associated protein 299 | 0.0482952 |
| SP100 | SP100 nuclear antigen | 0.0467941 |
| RIGI | RNA sensor RIG-I | 0.0462627 |
| PODXL | podocalyxin-like | 0.0449117 |
| TXNIP | thioredoxin interacting protein | 0.0442949 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0420794 |
| PRELID2 | PRELI domain containing 2 | 0.0419073 |
| VIM | vimentin | 0.0414876 |
| RPL26 | ribosomal protein L26 | 0.0409323 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0408233 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0395791 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0390624 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0382293 |
| TMSB4X | thymosin beta 4, X-linked | 0.0376558 |
| JUN | jun proto-oncogene | 0.0354436 |
| SMYD3 | SET and MYND domain containing 3 | 0.0351185 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0348303 |
| ECE1 | endothelin converting enzyme 1 | 0.0341706 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0338866 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0331246 |
| RPS12 | ribosomal protein S12 | 0.0325897 |
| EHBP1 | EH domain binding protein 1 | 0.0324873 |
| TRIM56 | tripartite motif containing 56 | 0.0323308 |
| ANGPTL4 | angiopoietin-like 4 | 0.0317805 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.0308757 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0307395 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0306159 |
| HLA-B | major histocompatibility complex, class I, B | 0.0302944 |
| B2M | beta-2-microglobulin | 0.0297224 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0296022 |
| RPL36 | ribosomal protein L36 | 0.0295582 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0294192 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0293576 |
| MT1E | metallothionein 1E | 0.0293363 |
| CDK6 | cyclin-dependent kinase 6 | 0.029315 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.028962 |
| PLSCR1 | phospholipid scramblase 1 | 0.0288595 |
| ANXA2 | annexin A2 | 0.0287696 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0284562 |
| TBC1D5 | TBC1 domain family, member 5 | 0.028337 |
| TPRG1 | tumor protein p63 regulated 1 | 0.0281446 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0280387 |
| RPL37A | ribosomal protein L37a | 0.0279733 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0279268 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0278961 |
| PRKCE | protein kinase C, epsilon | 0.0278782 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0278311 |
| RPS3 | ribosomal protein S3 | 0.0278291 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0275561 |
| PLK2 | polo-like kinase 2 | 0.0273786 |
| VMP1 | vacuole membrane protein 1 | 0.027288 |
| TNS3 | tensin 3 | 0.0270311 |
| RACK1 | receptor for activated C kinase 1 | 0.0269271 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0262953 |
| RPL12 | ribosomal protein L12 | 0.0262005 |
| PLIN2 | perilipin 2 | 0.0261865 |
| KRT18 | keratin 18, type I | 0.0261327 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0258093 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0254553 |
| RAD50 | RAD50 homolog (S. cerevisiae) | 0.0253346 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0252548 |
| ADAR | adenosine deaminase, RNA-specific | 0.0252093 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0251777 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0251605 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.0251093 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0250805 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0249244 |
| MOK | MOK protein kinase | 0.0249051 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.228386 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.146394 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.140015 |
| PTMA | prothymosin, alpha | -0.0958657 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0821163 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0698885 |
| SPAG9 | sperm associated antigen 9 | -0.069561 |
| CENPF | centromere protein F, 350/400kDa | -0.0693915 |
| POTEF | POTE ankyrin domain family, member F | -0.0677497 |
| TMSB10 | thymosin beta 10 | -0.0639452 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0617206 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0607933 |
| USP34 | ubiquitin specific peptidase 34 | -0.0560116 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.053357 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0526601 |
| MKI67 | marker of proliferation Ki-67 | -0.0446499 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0436792 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0417153 |
| TXNRD1 | thioredoxin reductase 1 | -0.0402514 |
| PUM2 | pumilio RNA-binding family member 2 | -0.038312 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0361403 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0359134 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0358093 |
| ZNF207 | zinc finger protein 207 | -0.0347103 |
| BRD2 | bromodomain containing 2 | -0.0342004 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0341877 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0341056 |
| RAB7A | RAB7A, member RAS oncogene family | -0.033731 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.033664 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0336112 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0330422 |
| CLTC | clathrin, heavy chain (Hc) | -0.0326874 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.032079 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0319959 |
| JMJD1C | jumonji domain containing 1C | -0.0315877 |
| EGR1 | early growth response 1 | -0.0309809 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0307794 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | -0.0303576 |
| NUP58 | nucleoporin 58 | -0.0298361 |
| RBM39 | RNA binding motif protein 39 | -0.0296889 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0295229 |
| ACTG1 | actin gamma 1 | -0.0288576 |
| RYBP | RING1 and YY1 binding protein | -0.0286726 |
| XPO1 | exportin 1 | -0.0285893 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0285389 |
| GAN | gigaxonin | -0.0284387 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0276809 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0276357 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0275817 |
| PANK3 | pantothenate kinase 3 | -0.0275279 |
| FTL | ferritin, light polypeptide | -0.0274809 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0273652 |
| ZNF217 | zinc finger protein 217 | -0.0273378 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0271651 |
| TPX2 | TPX2, microtubule-associated | -0.026879 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0267823 |
| RCOR1 | REST corepressor 1 | -0.0267736 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0266149 |
| WDR45B | WD repeat domain 45B | -0.026521 |
| PAPOLA | poly(A) polymerase alpha | -0.0263356 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0260904 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0260751 |
| ECT2 | epithelial cell transforming 2 | -0.0260725 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0259577 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0258468 |
| MORF4L2 | mortality factor 4 like 2 | -0.0256546 |
| COG5 | component of oligomeric golgi complex 5 | -0.0255141 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0254701 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.025163 |
| ANLN | anillin, actin binding protein | -0.0248933 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.024569 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0241194 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0240653 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.024031 |
| RPL3 | ribosomal protein L3 | -0.023991 |
| CDC73 | cell division cycle 73 | -0.0239234 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0238883 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.023372 |
| KIF1B | kinesin family member 1B | -0.0232535 |
| PYGB | phosphorylase, glycogen; brain | -0.0232364 |
| TOP1 | topoisomerase (DNA) I | -0.0232055 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0231265 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0231156 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0228753 |
| FNIP1 | folliculin interacting protein 1 | -0.022841 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0227223 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0226158 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0223563 |
| ANXA1 | annexin A1 | -0.0223053 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | -0.0221482 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | -0.0221023 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0220848 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.0219244 |
| WASF2 | WAS protein family, member 2 | -0.0216169 |
| FNBP1 | formin binding protein 1 | -0.0214472 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0214407 |
| PKM | pyruvate kinase, muscle | -0.0213762 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -0.0212719 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0211738 |
| QKI | QKI, KH domain containing, RNA binding | -0.0211312 |
