| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tofacitinib (citrate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.156251 |
| FAM13A | family with sequence similarity 13, member A | 0.0952968 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0945451 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.093332 |
| MCL1 | myeloid cell leukemia 1 | 0.0911224 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0823829 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0788905 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0785656 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.078418 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0728535 |
| LMO7 | LIM domain 7 | 0.0715737 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0685395 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0641669 |
| VMP1 | vacuole membrane protein 1 | 0.0632284 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0607774 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0593124 |
| NDRG1 | N-myc downstream regulated 1 | 0.0574107 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0568996 |
| SLTM | SAFB-like, transcription modulator | 0.0567555 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0551897 |
| MSN | moesin | 0.054251 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0539402 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0510219 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.050794 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0485046 |
| EGFR | epidermal growth factor receptor | 0.0478069 |
| JMJD1C | jumonji domain containing 1C | 0.0461216 |
| CAV2 | caveolin 2 | 0.0456369 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.04332 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.042985 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0419363 |
| VEGFA | vascular endothelial growth factor A | 0.0415935 |
| DSPP | dentin sialophosphoprotein | 0.0413872 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0404957 |
| MYOF | myoferlin | 0.0404224 |
| ENO1 | enolase 1, (alpha) | 0.0400732 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0396171 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0389568 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.037884 |
| GRAMD1B | GRAM domain containing 1B | 0.0373156 |
| ZNF638 | zinc finger protein 638 | 0.0367229 |
| BMP6 | bone morphogenetic protein 6 | 0.0362161 |
| GOLGA4 | golgin A4 | 0.0359682 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0354336 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0350275 |
| SCEL | sciellin | 0.0349135 |
| ITSN2 | intersectin 2 | 0.0341545 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0340848 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0337276 |
| SMYD3 | SET and MYND domain containing 3 | 0.0336608 |
| ANXA1 | annexin A1 | 0.0335418 |
| BRD2 | bromodomain containing 2 | 0.0327402 |
| CD163L1 | CD163 molecule-like 1 | 0.0316258 |
| SRP54 | signal recognition particle 54kDa | 0.0316218 |
| PTEN | phosphatase and tensin homolog | 0.031616 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0315477 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0309991 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0305865 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0305365 |
| DIAPH1 | diaphanous-related formin 1 | 0.0304087 |
| ANXA5 | annexin A5 | 0.0300897 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0293078 |
| PLS3 | plastin 3 | 0.0288054 |
| COPA | coatomer protein complex, subunit alpha | 0.0283651 |
| GOLGB1 | golgin B1 | 0.0282894 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0282702 |
| PCBP2 | poly(rC) binding protein 2 | 0.0282545 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0281837 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0277457 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0266153 |
| ARRDC3 | arrestin domain containing 3 | 0.0264987 |
| CCNL1 | cyclin L1 | 0.0264842 |
| HYOU1 | hypoxia up-regulated 1 | 0.0258555 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.0255498 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0253143 |
| CPE | carboxypeptidase E | 0.0251943 |
| POTEF | POTE ankyrin domain family, member F | 0.0251898 |
| OFD1 | oral-facial-digital syndrome 1 | 0.025123 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0250373 |
| ANKRD37 | ankyrin repeat domain 37 | 0.025018 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0250134 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0246182 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0245425 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.024007 |
| FOXP1 | forkhead box P1 | 0.0240019 |
| ARF4 | ADP-ribosylation factor 4 | 0.023948 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0233659 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0231552 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.022804 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0227795 |
| ANXA2 | annexin A2 | 0.0223701 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0223133 |
| DTNA | dystrobrevin, alpha | 0.0222752 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0221243 |
| ATN1 | atrophin 1 | 0.0221035 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0217681 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0215748 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0215232 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0214315 |
| BPTF | bromodomain PHD finger transcription factor | 0.0213982 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.165149 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.127163 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.121224 |
| TMSB10 | thymosin beta 10 | -0.120106 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.115873 |
| ASPH | aspartate beta-hydroxylase | -0.11426 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0931215 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0877305 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0795156 |
| RPS24 | ribosomal protein S24 | -0.0742004 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0728702 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0636567 |
| H1-0 | H1.0 linker histone | -0.0606989 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0596104 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0566369 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0560239 |
| MKI67 | marker of proliferation Ki-67 | -0.0548482 |
| OSMR | oncostatin M receptor | -0.0548235 |
| RPL35A | ribosomal protein L35a | -0.0546999 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0538395 |
| PGK1 | phosphoglycerate kinase 1 | -0.0532516 |
| MT2A | metallothionein 2A | -0.0525942 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0521448 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0513769 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0510227 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0509894 |
| GM2A | GM2 ganglioside activator | -0.0490261 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0476068 |
| RPL34 | ribosomal protein L34 | -0.0438286 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0427972 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0422632 |
| EFNA5 | ephrin-A5 | -0.0420692 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0406705 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0402521 |
| RPL37A | ribosomal protein L37a | -0.0399411 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0395944 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0390452 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0389675 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0386126 |
| RPS25 | ribosomal protein S25 | -0.0374594 |
| RPS8 | ribosomal protein S8 | -0.0361188 |
| GPC6 | glypican 6 | -0.0359213 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.0357522 |
| SDC4 | syndecan 4 | -0.0354247 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.035394 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0347979 |
| RPS21 | ribosomal protein S21 | -0.0346248 |
| RPLP1 | ribosomal protein, large, P1 | -0.0334936 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0334016 |
| VCL | vinculin | -0.0327524 |
| IER3 | immediate early response 3 | -0.0324516 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0321745 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.031606 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0313246 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0313131 |
| TKT | transketolase | -0.0312557 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0307969 |
| CES1 | carboxylesterase 1 | -0.0304159 |
| RPL23 | ribosomal protein L23 | -0.0302426 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0302392 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.029676 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0289197 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0287882 |
| ARF1 | ADP-ribosylation factor 1 | -0.0286228 |
| RPS23 | ribosomal protein S23 | -0.0284371 |
| ABLIM1 | actin binding LIM protein 1 | -0.0272425 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0272272 |
| POU2F1 | POU class 2 homeobox 1 | -0.0269968 |
| GNAS | GNAS complex locus | -0.0268255 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0265481 |
| RPS3 | ribosomal protein S3 | -0.0263427 |
| PATJ | PATJ crumbs cell polarity complex component | -0.026188 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | -0.0261826 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0258908 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0258429 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.0258306 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0257462 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.025296 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0252428 |
| RPL31 | ribosomal protein L31 | -0.0252128 |
| RPS6 | ribosomal protein S6 | -0.0251439 |
| SP100 | SP100 nuclear antigen | -0.0250232 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0250136 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0245954 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0245174 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.024142 |
| NABP1 | nucleic acid binding protein 1 | -0.0241138 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0241001 |
| RPL30 | ribosomal protein L30 | -0.0240809 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0240718 |
| RPL4 | ribosomal protein L4 | -0.023939 |
| FBXO34 | F-box protein 34 | -0.0238762 |
| TRIM56 | tripartite motif containing 56 | -0.0234066 |
| KRT7 | keratin 7, type II | -0.0233054 |
| S100A9 | S100 calcium binding protein A9 | -0.0225605 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0223271 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0222162 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0222015 |
| ACTG1 | actin gamma 1 | -0.0220992 |
| RBM39 | RNA binding motif protein 39 | -0.0220691 |
