| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.265577 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0955559 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0944916 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0883454 |
| HMGA2 | high mobility group AT-hook 2 | 0.0878401 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0858772 |
| VEGFA | vascular endothelial growth factor A | 0.0836135 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0795365 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0768669 |
| FN1 | fibronectin 1 | 0.0716342 |
| CDH13 | cadherin 13 | 0.0632857 |
| NAV2 | neuron navigator 2 | 0.0582358 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0559792 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0556972 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0542636 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0526616 |
| MTSS1 | metastasis suppressor 1 | 0.0522958 |
| RAI14 | retinoic acid induced 14 | 0.0474145 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0469711 |
| PYGL | phosphorylase, glycogen, liver | 0.045387 |
| ENO1 | enolase 1, (alpha) | 0.0445478 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0444445 |
| STC1 | stanniocalcin 1 | 0.0443048 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0439049 |
| CD44 | CD44 molecule (Indian blood group) | 0.0435884 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0420234 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0409687 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0406149 |
| PODXL | podocalyxin-like | 0.039339 |
| NRP1 | neuropilin 1 | 0.0376512 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0368161 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0360836 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0358025 |
| MEF2A | myocyte enhancer factor 2A | 0.0338917 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0333126 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0329318 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0329059 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.0324116 |
| DTNA | dystrobrevin, alpha | 0.032208 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0309747 |
| AHNAK | AHNAK nucleoprotein | 0.0300871 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0300855 |
| WLS | wntless Wnt ligand secretion mediator | 0.029975 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.029921 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.029564 |
| PLEC | plectin | 0.0294469 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0294075 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0290355 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0289711 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0289484 |
| IL1B | interleukin 1, beta | 0.0286525 |
| ASPH | aspartate beta-hydroxylase | 0.0286166 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0285236 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0284117 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0283786 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.027819 |
| CLMP | CXADR-like membrane protein | 0.0273507 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0272587 |
| HPCAL1 | hippocalcin-like 1 | 0.0272361 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | 0.0272025 |
| VIM | vimentin | 0.0270586 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0267051 |
| FRMD6 | FERM domain containing 6 | 0.0264355 |
| NDRG1 | N-myc downstream regulated 1 | 0.0263038 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0257463 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0255939 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0247593 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0244987 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.024383 |
| SEPTIN9 | septin 9 | 0.024335 |
| PRSS3 | protease, serine, 3 | 0.0238248 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0236573 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0233129 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0233106 |
| CDCP1 | CUB domain containing protein 1 | 0.0229149 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0228367 |
| RPS3 | ribosomal protein S3 | 0.022576 |
| GLCCI1 | glucocorticoid induced 1 | 0.0222645 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0222518 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0221771 |
| WWC2 | WW and C2 domain containing 2 | 0.0220402 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0219004 |
| LOXL2 | lysyl oxidase-like 2 | 0.0218531 |
| FAM20C | family with sequence similarity 20, member C | 0.021823 |
| FRMD3 | FERM domain containing 3 | 0.0217419 |
| ANO6 | anoctamin 6 | 0.0217198 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0216897 |
| SVIL | supervillin | 0.0213308 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0212268 |
| NAV1 | neuron navigator 1 | 0.0209758 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0209207 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0206815 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.0206527 |
| RPL26 | ribosomal protein L26 | 0.0206135 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.0203573 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.020225 |
| SNX9 | sorting nexin 9 | 0.0201585 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0201407 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0200554 |
| PLAT | plasminogen activator, tissue | 0.0199961 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.166959 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.125797 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.119269 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.114476 |
| RBM39 | RNA binding motif protein 39 | -0.104974 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0993138 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0985393 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0837351 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0757077 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0756526 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0745112 |
| OSMR | oncostatin M receptor | -0.0741803 |
| KYNU | kynureninase | -0.0649396 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0592595 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0587695 |
| GPC6 | glypican 6 | -0.058661 |
| VRK2 | vaccinia related kinase 2 | -0.05824 |
| USP34 | ubiquitin specific peptidase 34 | -0.0572559 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0546973 |
| LOX | lysyl oxidase | -0.052053 |
| VCL | vinculin | -0.0498109 |
| PTMA | prothymosin, alpha | -0.0490152 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0481971 |
| EGR1 | early growth response 1 | -0.0469537 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0461541 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0457687 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0456251 |
| TNNC1 | troponin C type 1 (slow) | -0.0452446 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0444492 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0443454 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0419799 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.0419675 |
| NRG1 | neuregulin 1 | -0.041629 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0414383 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0405093 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0401281 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0383657 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.038179 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0379218 |
| FTL | ferritin, light polypeptide | -0.0377761 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0373553 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0372054 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0365688 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0360271 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0355217 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0352988 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0348115 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0347619 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0340871 |
| SP100 | SP100 nuclear antigen | -0.0332755 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0332333 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0332171 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0327035 |
| MORF4L2 | mortality factor 4 like 2 | -0.0326454 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0326157 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0324393 |
| OGA | O-GlcNAcase | -0.0323059 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0322535 |
| SBF2 | SET binding factor 2 | -0.0322353 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0321506 |
| MX2 | MX dynamin-like GTPase 2 | -0.0320043 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0317187 |
| ETV6 | ets variant 6 | -0.0314119 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0314066 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0312861 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0310137 |
| GNAS | GNAS complex locus | -0.0310078 |
| DENND4A | DENN/MADD domain containing 4A | -0.0308609 |
| PARD3 | par-3 family cell polarity regulator | -0.0302035 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0298996 |
| SPAG9 | sperm associated antigen 9 | -0.0298653 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0297142 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0295404 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0294428 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0294068 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0293021 |
| DNER | delta/notch-like EGF repeat containing | -0.0289893 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0285726 |
| COG5 | component of oligomeric golgi complex 5 | -0.0285473 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0284593 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0282876 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0282012 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0281484 |
| GOLGA4 | golgin A4 | -0.0281297 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0279133 |
| EXOC6B | exocyst complex component 6B | -0.0279065 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0278985 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0275703 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0274023 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0272242 |
| SYAP1 | synapse associated protein 1 | -0.0271756 |
| ZNF609 | zinc finger protein 609 | -0.0271494 |
| WDR45B | WD repeat domain 45B | -0.0268966 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0268833 |
| RNF24 | ring finger protein 24 | -0.0268112 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0267692 |
| RPS21 | ribosomal protein S21 | -0.0267493 |
| USP15 | ubiquitin specific peptidase 15 | -0.0265052 |
| PCNX1 | pecanex 1 | -0.0262631 |
| TMEM263 | transmembrane protein 263 | -0.0261695 |
