| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.263764 |
| PM20D1 | peptidase M20 domain containing 1 | 0.261822 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.144714 |
| GRAMD1B | GRAM domain containing 1B | 0.141494 |
| FTL | ferritin, light polypeptide | 0.0933459 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0752175 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0693622 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.067161 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0627783 |
| WWOX | WW domain containing oxidoreductase | 0.058151 |
| CALR | calreticulin | 0.055746 |
| TXNRD1 | thioredoxin reductase 1 | 0.0538171 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0526745 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0520292 |
| RPS17 | ribosomal protein S17 | 0.0506904 |
| MCL1 | myeloid cell leukemia 1 | 0.0483989 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0482745 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0479392 |
| PTMA | prothymosin, alpha | 0.0476283 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0469943 |
| RPS25 | ribosomal protein S25 | 0.0454521 |
| WDR43 | WD repeat domain 43 | 0.043364 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.042008 |
| RPS29 | ribosomal protein S29 | 0.0419673 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.040362 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0398577 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0397856 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0397754 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0384924 |
| RPL37A | ribosomal protein L37a | 0.0377098 |
| MATR3 | matrin 3 | 0.0376146 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0370957 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0369335 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0358121 |
| B2M | beta-2-microglobulin | 0.0356416 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0353336 |
| RPS13 | ribosomal protein S13 | 0.0351552 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0348702 |
| RPL26 | ribosomal protein L26 | 0.0346958 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0341711 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0337001 |
| RPS23 | ribosomal protein S23 | 0.0331172 |
| CCNL1 | cyclin L1 | 0.0328283 |
| YBX3 | Y box binding protein 3 | 0.0320109 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0316218 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0311479 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0309291 |
| RPS27A | ribosomal protein S27a | 0.0308741 |
| RPL23 | ribosomal protein L23 | 0.0307315 |
| TFG | TRK-fused gene | 0.0306438 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0304364 |
| TPM3 | tropomyosin 3 | 0.0303257 |
| RPS3 | ribosomal protein S3 | 0.0290322 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.028524 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0284913 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0281107 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0276217 |
| RPL10A | ribosomal protein L10a | 0.0275039 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0271886 |
| YBX1 | Y box binding protein 1 | 0.026684 |
| RPS12 | ribosomal protein S12 | 0.0265825 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0265423 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0264744 |
| PFDN2 | prefoldin subunit 2 | 0.0263913 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0263607 |
| RPL13A | ribosomal protein L13a | 0.0262568 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0262489 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0261536 |
| RPL7 | ribosomal protein L7 | 0.0258076 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0256389 |
| RPS10 | ribosomal protein S10 | 0.0256351 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0254626 |
| RPL37 | ribosomal protein L37 | 0.0253879 |
| AHR | aryl hydrocarbon receptor | 0.0253595 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0253477 |
| RPLP1 | ribosomal protein, large, P1 | 0.0251586 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0251532 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0251401 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0251321 |
| RCC1 | regulator of chromosome condensation 1 | 0.0251045 |
| RPL19 | ribosomal protein L19 | 0.0249165 |
| RPL4 | ribosomal protein L4 | 0.0248824 |
| RPS8 | ribosomal protein S8 | 0.0245987 |
| CASC3 | cancer susceptibility candidate 3 | 0.0244293 |
| APP | amyloid beta (A4) precursor protein | 0.0243633 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0243115 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0243065 |
| BMP6 | bone morphogenetic protein 6 | 0.0242092 |
| RHOA | ras homolog family member A | 0.0241189 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0235562 |
| RPS2 | ribosomal protein S2 | 0.0235445 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0233968 |
| RPS21 | ribosomal protein S21 | 0.0233305 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0232774 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0232609 |
| RPS7 | ribosomal protein S7 | 0.0231695 |
| UBC | ubiquitin C | 0.0231164 |
| VMP1 | vacuole membrane protein 1 | 0.0230107 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0229374 |
| RNF145 | ring finger protein 145 | 0.0227907 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.174877 |
| TMSB10 | thymosin beta 10 | -0.121994 |
| VIM | vimentin | -0.120745 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0816628 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0738878 |
| CMIP | c-Maf inducing protein | -0.0705888 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0691532 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0620886 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0565675 |
| STC1 | stanniocalcin 1 | -0.0544185 |
| BICC1 | BicC family RNA binding protein 1 | -0.0533808 |
| PYGL | phosphorylase, glycogen, liver | -0.0525264 |
| NEBL | nebulette | -0.05176 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0489081 |
| IGF2 | insulin-like growth factor 2 | -0.0466145 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0451711 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.041182 |
| MYOF | myoferlin | -0.0409223 |
| FLNB | filamin B, beta | -0.0401597 |
| SNX14 | sorting nexin 14 | -0.0399301 |
| ACTG1 | actin gamma 1 | -0.0396051 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0394423 |
| ZFHX3 | zinc finger homeobox 3 | -0.0389159 |
| TPM4 | tropomyosin 4 | -0.0373061 |
| LDHA | lactate dehydrogenase A | -0.0356959 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.035608 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.03525 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0348281 |
| HMGA1 | high mobility group AT-hook 1 | -0.0346722 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0343857 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0340409 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.033936 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0338851 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0333081 |
| GNAS | GNAS complex locus | -0.0332405 |
| NDRG1 | N-myc downstream regulated 1 | -0.033051 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0323703 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0322053 |
| SHTN1 | shootin 1 | -0.0317253 |
| EGFR | epidermal growth factor receptor | -0.031061 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0310039 |
| CFDP1 | craniofacial development protein 1 | -0.0307111 |
| AK1 | adenylate kinase 1 | -0.030608 |
| S100A6 | S100 calcium binding protein A6 | -0.0303202 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0303162 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0301233 |
| PKM | pyruvate kinase, muscle | -0.0300709 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0299334 |
| PDE8A | phosphodiesterase 8A | -0.0293852 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0292442 |
| NHSL1 | NHS-like 1 | -0.0287188 |
| ERBIN | erbb2 interacting protein | -0.0281186 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0279823 |
| EFNA5 | ephrin-A5 | -0.0268439 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0265897 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0265008 |
| CAVIN1 | caveolae associated protein 1 | -0.0260762 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0260381 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0260185 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0255173 |
| DST | dystonin | -0.0253485 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.024642 |
| TMEM131 | transmembrane protein 131 | -0.0245989 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0244003 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0243157 |
| ATXN1 | ataxin 1 | -0.0240398 |
| SEC24A | SEC24 family member A | -0.0238367 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0237809 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0233296 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0227268 |
| VCL | vinculin | -0.0227244 |
| STC2 | stanniocalcin 2 | -0.022657 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.02242 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0223623 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0221612 |
| RAD51B | RAD51 paralog B | -0.0220165 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0219524 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0218095 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0216776 |
| TAGLN2 | transgelin 2 | -0.0216418 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0215539 |
| PRKD1 | protein kinase D1 | -0.0214986 |
| HDAC9 | histone deacetylase 9 | -0.0214123 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0214075 |
| RRBP1 | ribosome binding protein 1 | -0.021036 |
| SEPTIN10 | septin 10 | -0.0209692 |
| COL4A3 | collagen, type IV, alpha 3 (Goodpasture antigen) | -0.0208647 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0208517 |
| DYNC1I2 | dynein, cytoplasmic 1, intermediate chain 2 | -0.0207742 |
| UBE4B | ubiquitination factor E4B | -0.0206903 |
| EHBP1 | EH domain binding protein 1 | -0.020535 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0204943 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0202767 |
| PRR16 | proline rich 16 | -0.0202613 |
| ERLEC1 | endoplasmic reticulum lectin 1 | -0.0202055 |
| TRIP11 | thyroid hormone receptor interactor 11 | -0.0201871 |
| PFN1 | profilin 1 | -0.0201384 |
| SCFD1 | sec1 family domain containing 1 | -0.0200804 |
| MORF4L2 | mortality factor 4 like 2 | -0.0198816 |
| MAP1B | microtubule-associated protein 1B | -0.0196994 |
