Tofacitinib (citrate)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tofacitinib (citrate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tofacitinib (citrate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNIP thioredoxin interacting protein 0.11095
TXNRD1 thioredoxin reductase 1 0.0947741
LMO7 LIM domain 7 0.0901842
PDE10A phosphodiesterase 10A 0.0859386
HDAC9 histone deacetylase 9 0.0760378
ANXA1 annexin A1 0.0754261
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0727291
FAF1 Fas (TNFRSF6) associated factor 1 0.0698168
MCTP1 multiple C2 domains, transmembrane 1 0.0688381
TRIO trio Rho guanine nucleotide exchange factor 0.0658682
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0651207
GPBP1 GC-rich promoter binding protein 1 0.063131
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.062896
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0610838
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0597116
RUNX1 runt-related transcription factor 1 0.0589585
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0588113
ANO6 anoctamin 6 0.0566146
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0545684
CELF1 CUGBP, Elav-like family member 1 0.0537628
SPAG9 sperm associated antigen 9 0.0523863
TM4SF1 transmembrane 4 L six family member 1 0.0518697
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0515354
RAD51B RAD51 paralog B 0.051098
NAV2 neuron navigator 2 0.0506484
RB1CC1 RB1-inducible coiled-coil 1 0.0501487
TBC1D5 TBC1 domain family, member 5 0.0499944
HM13 histocompatibility (minor) 13 0.0499271
ABLIM1 actin binding LIM protein 1 0.049312
NCKAP1 NCK-associated protein 1 0.0484872
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0482843
WNK1 WNK lysine deficient protein kinase 1 0.0478863
TPR translocated promoter region, nuclear basket protein 0.0473294
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0473068
KLF5 Kruppel-like factor 5 (intestinal) 0.047144
MBNL1 muscleblind-like splicing regulator 1 0.0471263
TPD52 tumor protein D52 0.0470722
NALF1 NALCN channel auxiliary factor 1 0.0467599
ERRFI1 ERBB receptor feedback inhibitor 1 0.0466708
ARB2A ARB2 cotranscriptional regulator A 0.0459617
TUFT1 tuftelin 1 0.0457931
SLC38A1 solute carrier family 38, member 1 0.0457761
AGO3 argonaute RISC catalytic component 3 0.0452864
PBX3 pre-B-cell leukemia homeobox 3 0.0452506
USP34 ubiquitin specific peptidase 34 0.0452215
TUSC3 tumor suppressor candidate 3 0.0451143
AHR aryl hydrocarbon receptor 0.0450462
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.044724
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0426847
FTH1 ferritin, heavy polypeptide 1 0.0424162
GPHN gephyrin 0.0423746
NKD1 naked cuticle homolog 1 (Drosophila) 0.0423205
MYH9 myosin, heavy chain 9, non-muscle 0.0422784
GATAD2B GATA zinc finger domain containing 2B 0.0416343
ECPAS Ecm29 proteasome adaptor and scaffold 0.0411606
USP53 ubiquitin specific peptidase 53 0.0404917
HMGA2 high mobility group AT-hook 2 0.0404122
FLNB filamin B, beta 0.0394801
KATNBL1 katanin p80 subunit B-like 1 0.0393529
FRMD5 FERM domain containing 5 0.0393197
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0392698
BRWD1 bromodomain and WD repeat domain containing 1 0.039255
CAMTA1 calmodulin binding transcription activator 1 0.0391287
NAMPT nicotinamide phosphoribosyltransferase 0.0387915
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0386366
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0385439
EXT1 exostosin glycosyltransferase 1 0.0384783
PRELID2 PRELI domain containing 2 0.0383436
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0378461
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0377194
FXR1 fragile X mental retardation, autosomal homolog 1 0.0376238
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0375064
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0374355
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0373854
GOLGB1 golgin B1 0.0366992
IL6ST interleukin 6 signal transducer 0.0364192
USP24 ubiquitin specific peptidase 24 0.0361842
TTC17 tetratricopeptide repeat domain 17 0.0360407
SYT1 synaptotagmin I 0.0359735
PTK2 protein tyrosine kinase 2 0.035973
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0358991
KRT17 keratin 17, type I 0.0356565
JAK1 Janus kinase 1 0.0353912
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0350509
NCOA3 nuclear receptor coactivator 3 0.0349047
ZC3H11A zinc finger CCCH-type containing 11A 0.0346129
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0345116
FMN1 formin 1 0.0343557
SMYD3 SET and MYND domain containing 3 0.034323
PTGR1 prostaglandin reductase 1 0.0340432
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0340333
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0339861
RNF149 ring finger protein 149 0.0339671
PAPOLA poly(A) polymerase alpha 0.03393
GPC6 glypican 6 0.0337564
RIOK3 RIO kinase 3 0.0336018
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0335205
FOXP1 forkhead box P1 0.0334457
FMNL2 formin-like 2 0.0331494
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0329792

decreased expression

Symbol Name Standardized Value
MUC16 mucin 16, cell surface associated -0.180499
GRB10 growth factor receptor-bound protein 10 -0.139913
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.124026
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.106442
PTPRM protein tyrosine phosphatase, receptor type, M -0.103049
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0942042
CEMIP cell migration inducing protein, hyaluronan binding -0.0920946
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0863165
MYO1E myosin IE -0.0860663
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0788293
AKAP12 A kinase (PRKA) anchor protein 12 -0.0767417
KIF13B kinesin family member 13B -0.0706455
ARHGAP21 Rho GTPase activating protein 21 -0.068164
IGFBP3 insulin-like growth factor binding protein 3 -0.0680942
DLG1 discs, large homolog 1 (Drosophila) -0.066536
HLA-B major histocompatibility complex, class I, B -0.0664582
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0660165
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.065699
SPNS2 spinster homolog 2 (Drosophila) -0.0642601
LIMCH1 LIM and calponin homology domains 1 -0.0638754
LAMC2 laminin, gamma 2 -0.0621185
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0611727
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0606862
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0606595
MED13 mediator complex subunit 13 -0.0601418
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0584049
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0581625
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0572875
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0564652
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0548712
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0547055
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0545193
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0535612
IFIH1 interferon induced with helicase C domain 1 -0.0531204
VCL vinculin -0.0524951
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0521472
FNDC3B fibronectin type III domain containing 3B -0.0513115
AK1 adenylate kinase 1 -0.0504743
OSMR oncostatin M receptor -0.050399
LAMB3 laminin, beta 3 -0.0494914
DOCK5 dedicator of cytokinesis 5 -0.0485652
TPM4 tropomyosin 4 -0.0483295
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0475022
BACE2 beta-site APP-cleaving enzyme 2 -0.0474761
ANKRD36C ankyrin repeat domain 36C -0.0473417
MACF1 microtubule-actin crosslinking factor 1 -0.0462194
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0461268
ANTXR2 anthrax toxin receptor 2 -0.0454787
MED13L mediator complex subunit 13-like -0.0439415
TMEM41B transmembrane protein 41B -0.0438489
TMEM87A transmembrane protein 87A -0.043255
EXOC6B exocyst complex component 6B -0.0427453
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0426308
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0425021
UBC ubiquitin C -0.0423918
TPT1 tumor protein, translationally-controlled 1 -0.0421174
BASP1 brain abundant, membrane attached signal protein 1 -0.0414168
SOX4 SRY (sex determining region Y)-box 4 -0.041322
ABI1 abl-interactor 1 -0.0412042
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0411033
CSNK1A1 casein kinase 1, alpha 1 -0.0409422
ITCH itchy E3 ubiquitin protein ligase -0.0405778
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0405011
PTMA prothymosin, alpha -0.0402732
RPLP0 ribosomal protein, large, P0 -0.0402334
DENND4A DENN/MADD domain containing 4A -0.0401602
PDE4D phosphodiesterase 4D, cAMP-specific -0.0399891
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0397141
CNKSR3 CNKSR family member 3 -0.0396375
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0389185
TMSB10 thymosin beta 10 -0.0388944
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0381162
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0380432
AKAP13 A kinase (PRKA) anchor protein 13 -0.0378851
VIM vimentin -0.0375867
SVIL supervillin -0.0371717
MYOF myoferlin -0.0368497
CATSPERB catsper channel auxiliary subunit beta -0.0368348
MYO10 myosin X -0.0366204
HMBOX1 homeobox containing 1 -0.0362963
ANKRD11 ankyrin repeat domain 11 -0.0362354
NLGN1 neuroligin 1 -0.0362262
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.036147
GMDS GDP-mannose 4,6-dehydratase -0.0360284
ATP13A3 ATPase type 13A3 -0.0359761
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0353281
NIPBL Nipped-B homolog (Drosophila) -0.0352921
MON2 MON2 homolog (S. cerevisiae) -0.0352789
CD46 CD46 molecule, complement regulatory protein -0.0347013
RAB2A RAB2A, member RAS oncogene family -0.0339994
ARHGAP32 Rho GTPase activating protein 32 -0.0339821
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0338436
RORA RAR-related orphan receptor A -0.033477
FHIT fragile histidine triad -0.0333453
FOSL2 FOS-like antigen 2 -0.0332513
AKAP9 A kinase (PRKA) anchor protein 9 -0.0332196
TPCN1 two pore segment channel 1 -0.0330473
SNX9 sorting nexin 9 -0.0327389
ACTN4 actinin, alpha 4 -0.0326301
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0324987