| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.292719 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.125392 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.108233 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0950165 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0889132 |
| TPM3 | tropomyosin 3 | 0.0792994 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0693803 |
| ENO1 | enolase 1, (alpha) | 0.0660937 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0592425 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.058531 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0566244 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0552077 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0549841 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0542081 |
| RPS3 | ribosomal protein S3 | 0.0528945 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0505386 |
| COPA | coatomer protein complex, subunit alpha | 0.0458011 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.045429 |
| KRT18 | keratin 18, type I | 0.0445439 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0404204 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0385662 |
| CCNL1 | cyclin L1 | 0.0384235 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0373928 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0372458 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0366179 |
| TPM2 | tropomyosin 2 (beta) | 0.0364831 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0361399 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0344877 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0344553 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0338494 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0333714 |
| MSN | moesin | 0.0314074 |
| ARF4 | ADP-ribosylation factor 4 | 0.0307741 |
| PREPL | prolyl endopeptidase-like | 0.0299381 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.029768 |
| YBX1 | Y box binding protein 1 | 0.0291978 |
| JMJD1C | jumonji domain containing 1C | 0.0291245 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0288051 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0284878 |
| BRD2 | bromodomain containing 2 | 0.0283598 |
| MCL1 | myeloid cell leukemia 1 | 0.0278074 |
| SESN2 | sestrin 2 | 0.0278026 |
| LDHA | lactate dehydrogenase A | 0.0272785 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0270278 |
| RPL37A | ribosomal protein L37a | 0.0269958 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0266001 |
| MT2A | metallothionein 2A | 0.0257607 |
| POTEF | POTE ankyrin domain family, member F | 0.0254873 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0254483 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0254274 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0254181 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0253332 |
| PNN | pinin, desmosome associated protein | 0.0247979 |
| TRIM33 | tripartite motif containing 33 | 0.0244708 |
| NOP58 | NOP58 ribonucleoprotein | 0.0240054 |
| RPS2 | ribosomal protein S2 | 0.0239737 |
| CANX | calnexin | 0.0237553 |
| MEF2D | myocyte enhancer factor 2D | 0.0237182 |
| RPS18 | ribosomal protein S18 | 0.0236492 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0234748 |
| SET | SET nuclear proto-oncogene | 0.023057 |
| RHOA | ras homolog family member A | 0.0229552 |
| TLN1 | talin 1 | 0.0225065 |
| TMF1 | TATA element modulatory factor 1 | 0.0223975 |
| PCBP2 | poly(rC) binding protein 2 | 0.0218663 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0218067 |
| GOLGB1 | golgin B1 | 0.0211696 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0209518 |
| FAM168A | family with sequence similarity 168, member A | 0.0209459 |
| NGLY1 | N-glycanase 1 | 0.0209449 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0209142 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.020773 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0207389 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.020564 |
| RPL26 | ribosomal protein L26 | 0.0203294 |
| ANXA5 | annexin A5 | 0.0202976 |
| CALR | calreticulin | 0.0202787 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0200282 |
| NOTCH2 | notch 2 | 0.0199955 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0199903 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0199603 |
| RPL9 | ribosomal protein L9 | 0.0199348 |
| ITSN2 | intersectin 2 | 0.0198973 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0197982 |
| MINK1 | misshapen-like kinase 1 | 0.0195489 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0195182 |
| NRDC | nardilysin convertase | 0.0192846 |
| TRIM9 | tripartite motif containing 9 | 0.0192463 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0192426 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0192357 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0191335 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0190956 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0190283 |
| HDGF | hepatoma-derived growth factor | 0.0189059 |
| TBC1D23 | TBC1 domain family, member 23 | 0.0188888 |
| LPIN1 | lipin 1 | 0.0188399 |
| GOLGA4 | golgin A4 | 0.0186838 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0186731 |
| CEP250 | centrosomal protein 250kDa | 0.0185137 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0183046 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI2 | tissue factor pathway inhibitor 2 | -0.148576 |
| TMSB10 | thymosin beta 10 | -0.0924563 |
| RAD51B | RAD51 paralog B | -0.090596 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0840425 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0821251 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0798757 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0738197 |
| OSMR | oncostatin M receptor | -0.0647421 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0634373 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0607861 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0592001 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0588489 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0547881 |
| PLSCR1 | phospholipid scramblase 1 | -0.0510175 |
| NABP1 | nucleic acid binding protein 1 | -0.0507151 |
| YBX3 | Y box binding protein 3 | -0.0495278 |
| KLF6 | Kruppel-like factor 6 | -0.04773 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0472126 |
| TXNRD1 | thioredoxin reductase 1 | -0.0470108 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0449183 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0446152 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0443489 |
| EXOC4 | exocyst complex component 4 | -0.043906 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0424206 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0412156 |
| RNF213 | ring finger protein 213 | -0.0410799 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0402409 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.040159 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0399513 |
| EGR1 | early growth response 1 | -0.0375971 |
| RPL32 | ribosomal protein L32 | -0.0370301 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0365427 |
| KIAA1328 | KIAA1328 | -0.0365007 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0363703 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0358343 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.035408 |
| RPL35A | ribosomal protein L35a | -0.035406 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0350737 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0343996 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0341441 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0334863 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0334331 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0331082 |
| RIGI | RNA sensor RIG-I | -0.033108 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0329846 |
| PMP22 | peripheral myelin protein 22 | -0.0322613 |
| RPL23 | ribosomal protein L23 | -0.0319548 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0317549 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0307049 |
| GNAS | GNAS complex locus | -0.0302455 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0295411 |
| TRIM56 | tripartite motif containing 56 | -0.0295072 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0291526 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0286606 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0286534 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0285991 |
| AEBP2 | AE binding protein 2 | -0.028262 |
| RPS21 | ribosomal protein S21 | -0.0279095 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.027786 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0271275 |
| VCL | vinculin | -0.0271199 |
| IER3 | immediate early response 3 | -0.0270108 |
| RPL19 | ribosomal protein L19 | -0.0268555 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0268069 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0268019 |
| MKI67 | marker of proliferation Ki-67 | -0.0264974 |
| CLTC | clathrin, heavy chain (Hc) | -0.0263206 |
| BSG | basigin (Ok blood group) | -0.0261413 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0261256 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0261154 |
| PCNX4 | pecanex 4 | -0.0258272 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0257302 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0256474 |
| PHF3 | PHD finger protein 3 | -0.025633 |
| INTS6 | integrator complex subunit 6 | -0.0256027 |
| DOCK3 | dedicator of cytokinesis 3 | -0.0255554 |
| WIPF2 | WAS/WASL interacting protein family, member 2 | -0.0252789 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0251643 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0251047 |
| TAOK1 | TAO kinase 1 | -0.0250426 |
| HMGA2 | high mobility group AT-hook 2 | -0.0248083 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0247397 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0246949 |
| VIM | vimentin | -0.0244019 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0240792 |
| KNTC1 | kinetochore associated 1 | -0.0239307 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0238434 |
| H1-0 | H1.0 linker histone | -0.0237963 |
| BBX | bobby sox homolog (Drosophila) | -0.0237598 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0237105 |
| RPL6 | ribosomal protein L6 | -0.0235024 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.023356 |
| EIF2S1 | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa | -0.0233096 |
| CHD4 | chromodomain helicase DNA binding protein 4 | -0.0231554 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0230978 |
| RAB10 | RAB10, member RAS oncogene family | -0.0229012 |
| ACTG1 | actin gamma 1 | -0.0228984 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0228044 |
| SMAD3 | SMAD family member 3 | -0.0227771 |
| CCND2 | cyclin D2 | -0.0227181 |
