| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.308082 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.157592 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.146122 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.104988 |
| NDRG1 | N-myc downstream regulated 1 | 0.0939932 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0876216 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0813931 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0778056 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0766505 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0762017 |
| FN1 | fibronectin 1 | 0.0716322 |
| FTL | ferritin, light polypeptide | 0.0714913 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0698167 |
| CANX | calnexin | 0.0608497 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0590207 |
| HMGB2 | high mobility group box 2 | 0.0584837 |
| RNF145 | ring finger protein 145 | 0.0575107 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0565973 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0538029 |
| CALR | calreticulin | 0.0532036 |
| RPS3 | ribosomal protein S3 | 0.0516655 |
| FAM13A | family with sequence similarity 13, member A | 0.0514629 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0470394 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0462852 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0454912 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0447992 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0438187 |
| MATR3 | matrin 3 | 0.0437442 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0435862 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0425182 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0408197 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0397867 |
| CCNL1 | cyclin L1 | 0.0392647 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0386382 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0385378 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0380319 |
| USP3 | ubiquitin specific peptidase 3 | 0.0374859 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0372992 |
| PTMA | prothymosin, alpha | 0.0365503 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0365058 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0363556 |
| RBM39 | RNA binding motif protein 39 | 0.0362689 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0361785 |
| RBM25 | RNA binding motif protein 25 | 0.0358045 |
| LAMC2 | laminin, gamma 2 | 0.0356452 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0356366 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.035389 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.034669 |
| APP | amyloid beta (A4) precursor protein | 0.0333579 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0323768 |
| RLF | rearranged L-myc fusion | 0.0321743 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0317191 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0311344 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0305366 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.03032 |
| TFG | TRK-fused gene | 0.0302973 |
| ANXA5 | annexin A5 | 0.0298606 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.029839 |
| NUP58 | nucleoporin 58 | 0.0298045 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0297357 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0296566 |
| ZNF292 | zinc finger protein 292 | 0.0293846 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0289774 |
| TPR | translocated promoter region, nuclear basket protein | 0.0287974 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0287205 |
| RPS2 | ribosomal protein S2 | 0.0287107 |
| VEGFA | vascular endothelial growth factor A | 0.0284257 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0280893 |
| RHEB | Ras homolog enriched in brain | 0.0279528 |
| ARRDC3 | arrestin domain containing 3 | 0.0276639 |
| YTHDC1 | YTH domain containing 1 | 0.0273984 |
| YBX1 | Y box binding protein 1 | 0.0273074 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0272934 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0271406 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0269955 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0268235 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0268121 |
| RTN4 | reticulon 4 | 0.0265367 |
| G0S2 | G0/G1 switch 2 | 0.0262893 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.026238 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0261701 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0261245 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0261172 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0258406 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0257544 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0257536 |
| RPL9 | ribosomal protein L9 | 0.0252319 |
| SLMAP | sarcolemma associated protein | 0.0251631 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0244781 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.024137 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0238699 |
| RPL11 | ribosomal protein L11 | 0.023652 |
| BRD2 | bromodomain containing 2 | 0.0235299 |
| RYBP | RING1 and YY1 binding protein | 0.0234529 |
| RPS12 | ribosomal protein S12 | 0.0232725 |
| QKI | QKI, KH domain containing, RNA binding | 0.0228256 |
| RNASE3 | ribonuclease, RNase A family, 3 | 0.0224926 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0224283 |
| RPL7 | ribosomal protein L7 | 0.0222807 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0220774 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.157846 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.154164 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.127605 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.114041 |
| POTEF | POTE ankyrin domain family, member F | -0.10674 |
| FBXO32 | F-box protein 32 | -0.0984597 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0871656 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0836787 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0833928 |
| EFNA5 | ephrin-A5 | -0.0795323 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0671479 |
| KRT7 | keratin 7, type II | -0.0642861 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0631159 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0614483 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0587187 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0586988 |
| CCND1 | cyclin D1 | -0.0582885 |
| VCL | vinculin | -0.0571512 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.054963 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.052379 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0505562 |
| RNF213 | ring finger protein 213 | -0.0503531 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0465536 |
| NAV2 | neuron navigator 2 | -0.0457928 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0449671 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0448148 |
| MX2 | MX dynamin-like GTPase 2 | -0.0440642 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0430776 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0416066 |
| CSTB | cystatin B (stefin B) | -0.0400755 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0396105 |
| FBXO34 | F-box protein 34 | -0.0395517 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0394787 |
| RAI14 | retinoic acid induced 14 | -0.0394637 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0390106 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0385613 |
| HLA-B | major histocompatibility complex, class I, B | -0.0381109 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.037746 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0373776 |
| PGBD5 | piggyBac transposable element derived 5 | -0.0372507 |
| ETV6 | ets variant 6 | -0.0367152 |
| MYO1E | myosin IE | -0.0365303 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0354461 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.035075 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0348815 |
| PALLD | palladin, cytoskeletal associated protein | -0.034698 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0345831 |
| HLA-A | major histocompatibility complex, class I, A | -0.0337078 |
| LMO7 | LIM domain 7 | -0.0333025 |
| ERBIN | erbb2 interacting protein | -0.032841 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0327071 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0317629 |
| TPM4 | tropomyosin 4 | -0.0314645 |
| MAP1B | microtubule-associated protein 1B | -0.0313289 |
| PLSCR1 | phospholipid scramblase 1 | -0.031248 |
| FAM3C | family with sequence similarity 3, member C | -0.0311075 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0301453 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0292001 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0291575 |
| KRT8 | keratin 8, type II | -0.0290825 |
| KRT19 | keratin 19, type I | -0.0281339 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0278888 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0266397 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0265539 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0265092 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0264489 |
| SCFD1 | sec1 family domain containing 1 | -0.0263445 |
| MCU | mitochondrial calcium uniporter | -0.02625 |
| FNIP1 | folliculin interacting protein 1 | -0.0262159 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0261626 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0260771 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0260406 |
| S100A10 | S100 calcium binding protein A10 | -0.0260107 |
| TAPBP | TAP binding protein (tapasin) | -0.0259257 |
| RAD51B | RAD51 paralog B | -0.02555 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0255114 |
| RBM47 | RNA binding motif protein 47 | -0.0254782 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0253286 |
| S100A6 | S100 calcium binding protein A6 | -0.025291 |
| RIGI | RNA sensor RIG-I | -0.0252304 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0248161 |
| CUX1 | cut-like homeobox 1 | -0.0244722 |
| MYO6 | myosin VI | -0.0244242 |
| OCLN | occludin | -0.0244005 |
| RRBP1 | ribosome binding protein 1 | -0.0239687 |
| MKI67 | marker of proliferation Ki-67 | -0.0239069 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.023847 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0238163 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0237858 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.023669 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0235107 |
| GNAS | GNAS complex locus | -0.0232197 |
| CTSD | cathepsin D | -0.0231628 |
| FRMD5 | FERM domain containing 5 | -0.0230478 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0230475 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.022973 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0225973 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0224851 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0223944 |
| GOLGB1 | golgin B1 | -0.0222473 |
