Tofacitinib (citrate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tofacitinib (citrate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tofacitinib (citrate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.17874
GDA guanine deaminase 0.17471
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.167174
COL8A1 collagen, type VIII, alpha 1 0.121867
GRAMD1B GRAM domain containing 1B 0.0953801
TRIO trio Rho guanine nucleotide exchange factor 0.0858895
ZEB2 zinc finger E-box binding homeobox 2 0.0753836
TXNRD1 thioredoxin reductase 1 0.0727852
PDLIM5 PDZ and LIM domain 5 0.0708759
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0691898
COL4A5 collagen, type IV, alpha 5 0.0626021
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0607345
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0553228
DST dystonin 0.0552475
COL5A2 collagen, type V, alpha 2 0.054622
FMNL2 formin-like 2 0.0531264
ESYT2 extended synaptotagmin-like protein 2 0.0526165
SAMD4A sterile alpha motif domain containing 4A 0.0515369
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.049583
KYNU kynureninase 0.0474165
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.04735
DOCK4 dedicator of cytokinesis 4 0.0469533
CD109 CD109 molecule 0.0460354
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0456483
FNDC3A fibronectin type III domain containing 3A 0.0453477
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0438317
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0435714
NAMPT nicotinamide phosphoribosyltransferase 0.0434723
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0402137
ELL2 elongation factor, RNA polymerase II, 2 0.0400035
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0400001
AKAP13 A kinase (PRKA) anchor protein 13 0.038609
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0377797
SPAG9 sperm associated antigen 9 0.0377421
RTN4 reticulon 4 0.0372472
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0372189
SH3KBP1 SH3-domain kinase binding protein 1 0.0366888
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.036169
PTEN phosphatase and tensin homolog 0.0353507
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0351011
RAB3B RAB3B, member RAS oncogene family 0.0345204
COL4A6 collagen, type IV, alpha 6 0.0344636
DOCK5 dedicator of cytokinesis 5 0.0343201
JMJD1C jumonji domain containing 1C 0.0340447
BCAR3 breast cancer anti-estrogen resistance 3 0.0338011
PRRC2C proline-rich coiled-coil 2C 0.0325484
SRPK2 SRSF protein kinase 2 0.0322064
RBM39 RNA binding motif protein 39 0.0320629
NPAS2 neuronal PAS domain protein 2 0.0319047
TGFBR1 transforming growth factor, beta receptor 1 0.0317301
CTIF CBP80/20-dependent translation initiation factor 0.0316186
ARHGAP29 Rho GTPase activating protein 29 0.0314566
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0309484
KDM6A lysine (K)-specific demethylase 6A 0.0303219
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0302684
ZFC3H1 zinc finger, C3H1-type containing 0.0298773
NEK7 NIMA-related kinase 7 0.0295752
ANKRD17 ankyrin repeat domain 17 0.0287714
WDR43 WD repeat domain 43 0.0285926
EZR ezrin 0.0275527
NF1 neurofibromin 1 0.0275071
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0272278
AGTPBP1 ATP/GTP binding protein 1 0.0272206
KMT2C lysine (K)-specific methyltransferase 2C 0.0270662
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0270553
VMP1 vacuole membrane protein 1 0.0267437
ANKRD28 ankyrin repeat domain 28 0.0266578
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0263261
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0258392
ITPRID2 ITPR interacting domain containing 2 0.02493
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0246911
P3H2 prolyl 3-hydroxylase 2 0.024478
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0242325
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0242122
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0240281
ZBTB38 zinc finger and BTB domain containing 38 0.0240114
ENAH enabled homolog (Drosophila) 0.02374
CSNK1A1 casein kinase 1, alpha 1 0.0236972
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0236913
RBM25 RNA binding motif protein 25 0.0236309
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.023602
TNPO1 transportin 1 0.0234926
OGA O-GlcNAcase 0.023319
CDK17 cyclin-dependent kinase 17 0.0231407
RBMS2 RNA binding motif, single stranded interacting protein 2 0.0230589
NT5C2 5'-nucleotidase, cytosolic II 0.0229781
RICTOR RPTOR independent companion of MTOR, complex 2 0.0228384
FLNB filamin B, beta 0.0227125
RNF145 ring finger protein 145 0.0226692
OSMR oncostatin M receptor 0.0225693
DGKD diacylglycerol kinase, delta 130kDa 0.0224238
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0219409
KIF21A kinesin family member 21A 0.0219332
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0218101
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0217027
MGST1 microsomal glutathione S-transferase 1 0.0216792
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0215807
ZNF638 zinc finger protein 638 0.0212397
UGCG UDP-glucose ceramide glucosyltransferase 0.0211539
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0206264

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.154596
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.138832
PDE4D phosphodiesterase 4D, cAMP-specific -0.130712
VIM vimentin -0.111118
TPT1 tumor protein, translationally-controlled 1 -0.10624
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.105926
PCBP3 poly(rC) binding protein 3 -0.100049
RPS6 ribosomal protein S6 -0.0941444
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0938286
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0929932
TMSB10 thymosin beta 10 -0.0817585
NALF1 NALCN channel auxiliary factor 1 -0.08062
RPLP1 ribosomal protein, large, P1 -0.0712867
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0712607
PRKN parkin RBR E3 ubiquitin protein ligase -0.0672237
RPL31 ribosomal protein L31 -0.066104
ASPH aspartate beta-hydroxylase -0.0658626
RPS8 ribosomal protein S8 -0.0630179
RPS24 ribosomal protein S24 -0.0619546
RPL35A ribosomal protein L35a -0.0619459
PSD3 pleckstrin and Sec7 domain containing 3 -0.0611859
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0598969
RAD51B RAD51 paralog B -0.0574305
RPL37A ribosomal protein L37a -0.056828
CDH13 cadherin 13 -0.0545716
RPS12 ribosomal protein S12 -0.0504853
AUTS2 autism susceptibility candidate 2 -0.0478752
RPS23 ribosomal protein S23 -0.0467179
VCL vinculin -0.0463957
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0450546
RPL23 ribosomal protein L23 -0.0448214
RPL12 ribosomal protein L12 -0.0439764
LSAMP limbic system-associated membrane protein -0.0438599
RPS27A ribosomal protein S27a -0.0423127
NCKAP5 NCK-associated protein 5 -0.0408043
PTMA prothymosin, alpha -0.0406216
RACK1 receptor for activated C kinase 1 -0.0399997
RPL34 ribosomal protein L34 -0.0394437
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0393957
ACTG1 actin gamma 1 -0.0388031
ENO1 enolase 1, (alpha) -0.0383794
CADM2 cell adhesion molecule 2 -0.0379225
RPS29 ribosomal protein S29 -0.0374648
EFNA5 ephrin-A5 -0.0371425
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0364931
RPL9 ribosomal protein L9 -0.036333
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0361619
EIF1 eukaryotic translation initiation factor 1 -0.0359672
RPL26 ribosomal protein L26 -0.0358415
RPL37 ribosomal protein L37 -0.0357498
RPL36A ribosomal protein L36a -0.0357374
PYGL phosphorylase, glycogen, liver -0.0350125
RPS27 ribosomal protein S27 -0.0349303
RPL19 ribosomal protein L19 -0.0347716
ADGRD1 adhesion G protein-coupled receptor D1 -0.03441
RPL38 ribosomal protein L38 -0.0339081
RPS19 ribosomal protein S19 -0.0322646
RPL7A ribosomal protein L7a -0.0307812
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0300982
RPL13A ribosomal protein L13a -0.0297657
RPS4X ribosomal protein S4, X-linked -0.0295217
RPS25 ribosomal protein S25 -0.0291769
RPS16 ribosomal protein S16 -0.0288756
LDHA lactate dehydrogenase A -0.0288284
RPLP0 ribosomal protein, large, P0 -0.028555
RPS3 ribosomal protein S3 -0.0279847
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0278705
RPL36 ribosomal protein L36 -0.0277208
FN1 fibronectin 1 -0.027587
GLRX glutaredoxin (thioltransferase) -0.0273251
RPS17 ribosomal protein S17 -0.027108
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0270497
NAP1L1 nucleosome assembly protein 1-like 1 -0.0268512
FTL ferritin, light polypeptide -0.0267383
RPS13 ribosomal protein S13 -0.0266961
RPL35 ribosomal protein L35 -0.0264442
SQSTM1 sequestosome 1 -0.0262822
RPLP2 ribosomal protein, large, P2 -0.0259715
RPS14 ribosomal protein S14 -0.025629
MT2A metallothionein 2A -0.0252324
RPL4 ribosomal protein L4 -0.0248795
RPL27 ribosomal protein L27 -0.0248683
GNAS GNAS complex locus -0.0244865
SOX6 SRY (sex determining region Y)-box 6 -0.0243497
PRELID2 PRELI domain containing 2 -0.0240326
PGK1 phosphoglycerate kinase 1 -0.0238355
LOC112694756 uncharaterized LOC112694756 -0.0237236
IGFBP3 insulin-like growth factor binding protein 3 -0.0234108
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -0.0233275
RPS10 ribosomal protein S10 -0.0230072
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0227539
PDIA3 protein disulfide isomerase family A, member 3 -0.0223129
GLIS3 GLIS family zinc finger 3 -0.0223126
RPS2 ribosomal protein S2 -0.0220548
S100A10 S100 calcium binding protein A10 -0.0219911
CANX calnexin -0.0218632
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.021557
RPL11 ribosomal protein L11 -0.021511
RPL32 ribosomal protein L32 -0.0210508
NACA nascent polypeptide-associated complex alpha subunit -0.0208711