Tofacitinib (citrate)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tofacitinib (citrate) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

131 genes differentially expressed following the Tofacitinib (citrate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.136367
NKD1 naked cuticle homolog 1 (Drosophila) 0.133078
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.124228
IGF2 insulin-like growth factor 2 0.11493
PDE4D phosphodiesterase 4D, cAMP-specific 0.111214
ZMYND8 zinc finger, MYND-type containing 8 0.102313
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0995828
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0907616
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0884887
NDRG1 N-myc downstream regulated 1 0.0833146
LAMA4 laminin, alpha 4 0.0818958
LDHA lactate dehydrogenase A 0.0801489
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0798619
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0763878
POTEF POTE ankyrin domain family, member F 0.0752139
ASPH aspartate beta-hydroxylase 0.0748082
NCOA3 nuclear receptor coactivator 3 0.0716084
PTPRM protein tyrosine phosphatase, receptor type, M 0.0685159
LMO7 LIM domain 7 0.0668876
OGA O-GlcNAcase 0.06394
INTS6 integrator complex subunit 6 0.063527
NAP1L1 nucleosome assembly protein 1-like 1 0.0623593
MYO1E myosin IE 0.0587601
MON2 MON2 homolog (S. cerevisiae) 0.0559073
PDLIM5 PDZ and LIM domain 5 0.0551525
MAML2 mastermind-like 2 (Drosophila) 0.0544342
SPAG9 sperm associated antigen 9 0.0514288
IGFBP5 insulin-like growth factor binding protein 5 0.0498884
KIZ kizuna centrosomal protein 0.0490632
ZBTB20 zinc finger and BTB domain containing 20 0.048599
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0462467
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0461686
CDH13 cadherin 13 0.0461571
PRRC2C proline-rich coiled-coil 2C 0.0458591
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0455961
SAMD4A sterile alpha motif domain containing 4A 0.044151
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0424929
NPAS2 neuronal PAS domain protein 2 0.0415073
EFNA5 ephrin-A5 0.0365891
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0364708
DST dystonin 0.0354827
STK24 serine/threonine kinase 24 0.0353039
PTPRK protein tyrosine phosphatase, receptor type, K 0.0344595
ACACA acetyl-CoA carboxylase alpha 0.0338934
PRELID2 PRELI domain containing 2 0.0318732
IGFBP3 insulin-like growth factor binding protein 3 0.0301932
SMYD3 SET and MYND domain containing 3 0.0299653
SYT1 synaptotagmin I 0.0295153
RPL35A ribosomal protein L35a 0.0294412
CMIP c-Maf inducing protein 0.028044
SOS1 son of sevenless homolog 1 (Drosophila) 0.0272152
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0252235
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.024086
MYOF myoferlin 0.0237742
FTL ferritin, light polypeptide 0.0220183
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0216271
USP34 ubiquitin specific peptidase 34 0.0200162
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0187171
FHIT fragile histidine triad 0.017311
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0172699
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0147171
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0145053
GPC6 glypican 6 0.0143947
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0125643
AHNAK AHNAK nucleoprotein 0.007949
RPL8 ribosomal protein L8 0.00575352
DSCAM Down syndrome cell adhesion molecule 0.00522517
NF1 neurofibromin 1 0.00439858
EGFR epidermal growth factor receptor 0.00328025
SBF2 SET binding factor 2 0.00317752
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.00254621
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.00231009
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.00184785
PGK1 phosphoglycerate kinase 1 8.61172E-4

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.242096
FN1 fibronectin 1 -0.189883
PTMA prothymosin, alpha -0.13279
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.126355
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.124929
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.119177
VIM vimentin -0.119047
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.117623
LPP LIM domain containing preferred translocation partner in lipoma -0.116201
RPS6 ribosomal protein S6 -0.114877
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.108686
AKAP12 A kinase (PRKA) anchor protein 12 -0.107663
ANKRD12 ankyrin repeat domain 12 -0.0921803
CD44 CD44 molecule (Indian blood group) -0.0875288
B2M beta-2-microglobulin -0.0802439
FNDC3B fibronectin type III domain containing 3B -0.0753153
PRKCA protein kinase C, alpha -0.0751838
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0725465
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0699112
ESYT2 extended synaptotagmin-like protein 2 -0.0660864
THSD4 thrombospondin, type I, domain containing 4 -0.0660187
COL6A3 collagen, type VI, alpha 3 -0.0602458
WSB1 WD repeat and SOCS box containing 1 -0.0598279
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0588237
MED13L mediator complex subunit 13-like -0.0579167
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0578344
INHBA inhibin, beta A -0.0571572
PSD3 pleckstrin and Sec7 domain containing 3 -0.0564659
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0530767
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0521363
SLTM SAFB-like, transcription modulator -0.0510147
NALF1 NALCN channel auxiliary factor 1 -0.0500061
TRIO trio Rho guanine nucleotide exchange factor -0.0401866
ANXA2 annexin A2 -0.033595
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0322975
SEC31A SEC31 homolog A (S. cerevisiae) -0.0311129
KMT2E lysine (K)-specific methyltransferase 2E -0.0303856
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0303459
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0294581
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0292698
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0290418
MT2A metallothionein 2A -0.0290385
RAD51B RAD51 paralog B -0.0282648
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0281959
ACTG1 actin gamma 1 -0.0277414
RPS3 ribosomal protein S3 -0.0236499
ERRFI1 ERBB receptor feedback inhibitor 1 -0.017638
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0175795
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0126503
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0121521
TPT1 tumor protein, translationally-controlled 1 -0.0116714
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0106096
PARD3 par-3 family cell polarity regulator -0.0102506
RPL12 ribosomal protein L12 -0.0085109
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.00804562
MAML3 mastermind-like 3 (Drosophila) -0.00676614
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.00187789