| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0656569 |
| JMJD1C | jumonji domain containing 1C | 0.0463952 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0408107 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0401801 |
| ARHGAP24 | Rho GTPase activating protein 24 | 0.0397652 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0366524 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0361038 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0350348 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0349998 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0349654 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0346339 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0335219 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0327945 |
| PTMA | prothymosin, alpha | 0.0313577 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0311672 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0310584 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0308454 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0306117 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0301701 |
| SETD5 | SET domain containing 5 | 0.029873 |
| PHIP | pleckstrin homology domain interacting protein | 0.0297401 |
| PRKD1 | protein kinase D1 | 0.0289879 |
| TCF12 | transcription factor 12 | 0.0289652 |
| SRPK2 | SRSF protein kinase 2 | 0.028908 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0286964 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0279945 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0266087 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.026444 |
| CENPF | centromere protein F, 350/400kDa | 0.0264344 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0263871 |
| PRKCI | protein kinase C, iota | 0.0261255 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0255111 |
| ITGAV | integrin, alpha V | 0.0251931 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0251836 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0251564 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0249723 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0246298 |
| GSE1 | Gse1 coiled-coil protein | 0.0245887 |
| NCKAP1 | NCK-associated protein 1 | 0.0242134 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0241279 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0239968 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0238074 |
| XPO1 | exportin 1 | 0.0236235 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0235269 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0232615 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0231286 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | 0.0230469 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0230321 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.022943 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.022864 |
| CALR | calreticulin | 0.0226165 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0225441 |
| KIF5B | kinesin family member 5B | 0.0223438 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0219899 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0219499 |
| GSPT1 | G1 to S phase transition 1 | 0.0218505 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0217985 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0217952 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.021723 |
| RREB1 | ras responsive element binding protein 1 | 0.0214655 |
| VEGFA | vascular endothelial growth factor A | 0.0212091 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0207867 |
| DSPP | dentin sialophosphoprotein | 0.0206839 |
| NCOR2 | nuclear receptor corepressor 2 | 0.020369 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.020311 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0201669 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0201243 |
| LDHA | lactate dehydrogenase A | 0.0200571 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0197822 |
| B2M | beta-2-microglobulin | 0.0197664 |
| CADM2 | cell adhesion molecule 2 | 0.0195466 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.0195438 |
| GREB1L | growth regulation by estrogen in breast cancer-like | 0.0194366 |
| NHSL1 | NHS-like 1 | 0.019385 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0193654 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0189926 |
| ATXN2 | ataxin 2 | 0.0189347 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.018864 |
| SVIL | supervillin | 0.0187076 |
| TLK1 | tousled-like kinase 1 | 0.0186674 |
| MED13L | mediator complex subunit 13-like | 0.0184936 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0184873 |
| GLI3 | GLI family zinc finger 3 | 0.0184104 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0182554 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.018166 |
| RHOA | ras homolog family member A | 0.0180017 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0177714 |
| CCDC88A | coiled-coil domain containing 88A | 0.0176826 |
| TMEM131 | transmembrane protein 131 | 0.0175332 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0175308 |
| TPM4 | tropomyosin 4 | 0.0174832 |
| TBL1X | transducin (beta)-like 1X-linked | 0.017444 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0173939 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0173364 |
| VRK2 | vaccinia related kinase 2 | 0.0172781 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0172025 |
| UBXN4 | UBX domain protein 4 | 0.0171155 |
| TRERF1 | transcriptional regulating factor 1 | 0.0170475 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0169546 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0169053 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.128665 |
| VIM | vimentin | -0.0799161 |
| EMP1 | epithelial membrane protein 1 | -0.0402953 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0402171 |
| MEIS2 | Meis homeobox 2 | -0.0386605 |
| THBS1 | thrombospondin 1 | -0.0380802 |
| AHNAK | AHNAK nucleoprotein | -0.0375024 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0370552 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0349941 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0333572 |
| ACTG1 | actin gamma 1 | -0.0326714 |
| COL3A1 | collagen, type III, alpha 1 | -0.0313808 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0311296 |
| SYT1 | synaptotagmin I | -0.0307662 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0301886 |
| PFN1 | profilin 1 | -0.0293877 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0293653 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0290748 |
| DST | dystonin | -0.0280399 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0274985 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0274795 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.026856 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0268515 |
| NRG1 | neuregulin 1 | -0.0263958 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0263832 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0257251 |
| FOXP2 | forkhead box P2 | -0.0253849 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.024115 |
| DMD | dystrophin | -0.0237931 |
| FAM171B | family with sequence similarity 171, member B | -0.0232136 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0227238 |
| ANXA1 | annexin A1 | -0.0223705 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.022006 |
| NOP58 | NOP58 ribonucleoprotein | -0.0215946 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0215913 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0212615 |
| YBX1 | Y box binding protein 1 | -0.0208587 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0208106 |
| RHEB | Ras homolog enriched in brain | -0.0205794 |
| TMSB4X | thymosin beta 4, X-linked | -0.0204832 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0201989 |
| SCFD1 | sec1 family domain containing 1 | -0.0201328 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | -0.0201326 |
| KIAA1328 | KIAA1328 | -0.0197941 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0197566 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0191736 |
| HMGA2 | high mobility group AT-hook 2 | -0.018914 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0188457 |
| RPS27A | ribosomal protein S27a | -0.0187563 |
| RPL23 | ribosomal protein L23 | -0.0187286 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0184935 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0184132 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.017783 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0177253 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0176879 |
| TOX | thymocyte selection-associated high mobility group box | -0.0176806 |
| ARF1 | ADP-ribosylation factor 1 | -0.017482 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0173913 |
| CCDC138 | coiled-coil domain containing 138 | -0.0173046 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0172432 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0172037 |
| CDK12 | cyclin-dependent kinase 12 | -0.0171716 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | -0.0171007 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.016849 |
| RFPL4B | ret finger protein-like 4B | -0.0168001 |
| LAMA2 | laminin, alpha 2 | -0.0167953 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0166875 |
| TBC1D12 | TBC1 domain family, member 12 | -0.0165753 |
| CDK13 | cyclin-dependent kinase 13 | -0.0165476 |
| CAVIN1 | caveolae associated protein 1 | -0.0164238 |
| GRB2 | growth factor receptor-bound protein 2 | -0.0162719 |
| GNAS | GNAS complex locus | -0.0161463 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.0160417 |
| ZNF385D | zinc finger protein 385D | -0.0159509 |
| VGLL3 | vestigial-like family member 3 | -0.0159107 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0158264 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0155469 |
| POTEF | POTE ankyrin domain family, member F | -0.0155108 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0153549 |
| HMGA1 | high mobility group AT-hook 1 | -0.0153405 |
| NPR2 | natriuretic peptide receptor 2 | -0.0152955 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0151976 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | -0.0151953 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0150635 |
| RPL32 | ribosomal protein L32 | -0.0150085 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0148364 |
| S100A10 | S100 calcium binding protein A10 | -0.0148356 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0147748 |
| PDSS2 | prenyl (decaprenyl) diphosphate synthase, subunit 2 | -0.0147729 |
| ZFHX4 | zinc finger homeobox 4 | -0.0146664 |
| TXNRD1 | thioredoxin reductase 1 | -0.014637 |
| LYST | lysosomal trafficking regulator | -0.014619 |
| UTRN | utrophin | -0.0145471 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0144356 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0143867 |
| RLF | rearranged L-myc fusion | -0.0143707 |
| TMSB10 | thymosin beta 10 | -0.0143002 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0142748 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0142599 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0141932 |
