| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.175649 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.122972 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0865799 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0777495 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0739493 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0603138 |
| TXNRD1 | thioredoxin reductase 1 | 0.0600561 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0552683 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0518163 |
| LAMB3 | laminin, beta 3 | 0.0497034 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0474866 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0468514 |
| JMJD1C | jumonji domain containing 1C | 0.0462942 |
| CALU | calumenin | 0.044585 |
| SET | SET nuclear proto-oncogene | 0.0444207 |
| FLNB | filamin B, beta | 0.0438609 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0432077 |
| NUP58 | nucleoporin 58 | 0.0431324 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0430002 |
| SETX | senataxin | 0.0429 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0427509 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0419103 |
| GOLGA4 | golgin A4 | 0.0418357 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0415494 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0405954 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.040541 |
| MTDH | metadherin | 0.0404427 |
| JUN | jun proto-oncogene | 0.0402872 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.039882 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.037496 |
| NF1 | neurofibromin 1 | 0.0355052 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0350771 |
| ANXA5 | annexin A5 | 0.0350057 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0348893 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0344439 |
| HDAC9 | histone deacetylase 9 | 0.0339104 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | 0.03358 |
| RASA2 | RAS p21 protein activator 2 | 0.0335197 |
| SRPK2 | SRSF protein kinase 2 | 0.0333816 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0333091 |
| PTK2 | protein tyrosine kinase 2 | 0.0332758 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0331429 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0328049 |
| ATP13A3 | ATPase type 13A3 | 0.0324946 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0324545 |
| CANX | calnexin | 0.0322048 |
| CRY1 | cryptochrome circadian clock 1 | 0.0321724 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0320744 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.0317365 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0301478 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0297897 |
| TMEM156 | transmembrane protein 156 | 0.0291363 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.028955 |
| DSCAM | Down syndrome cell adhesion molecule | 0.028838 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0286999 |
| TMEM41B | transmembrane protein 41B | 0.0285124 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.028501 |
| FNBP4 | formin binding protein 4 | 0.028312 |
| SNX9 | sorting nexin 9 | 0.0282421 |
| CALR | calreticulin | 0.0281988 |
| VMP1 | vacuole membrane protein 1 | 0.0279855 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0279852 |
| FUBP3 | far upstream element (FUSE) binding protein 3 | 0.0277906 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.02777 |
| TMF1 | TATA element modulatory factor 1 | 0.027676 |
| TPM4 | tropomyosin 4 | 0.0276086 |
| TPD52 | tumor protein D52 | 0.0275704 |
| FBXO11 | F-box protein 11 | 0.0273787 |
| PRKCI | protein kinase C, iota | 0.0273639 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0271174 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.026956 |
| BCL2L1 | BCL2-like 1 | 0.0267963 |
| CDC27 | cell division cycle 27 | 0.0267607 |
| CCNY | cyclin Y | 0.026585 |
| WDR43 | WD repeat domain 43 | 0.0265277 |
| AXL | AXL receptor tyrosine kinase | 0.0261406 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0260249 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0259639 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.0253879 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0251986 |
| USP3 | ubiquitin specific peptidase 3 | 0.025065 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0249263 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0248626 |
| STC1 | stanniocalcin 1 | 0.0248438 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.024824 |
| TCF12 | transcription factor 12 | 0.0247778 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.024274 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0242527 |
| SEC24A | SEC24 family member A | 0.0242188 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0241702 |
| MATR3 | matrin 3 | 0.0241088 |
| GAPVD1 | GTPase activating protein and VPS9 domains 1 | 0.0240699 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0240522 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.023895 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0238887 |
| CDC123 | cell division cycle 123 | 0.0238656 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0237388 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0237029 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0234479 |
| TJP1 | tight junction protein 1 | 0.023318 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FRMD6 | FERM domain containing 6 | -0.137335 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.129169 |
| ZNF438 | zinc finger protein 438 | -0.0826973 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0821987 |
| HMGA2 | high mobility group AT-hook 2 | -0.0799298 |
| NABP1 | nucleic acid binding protein 1 | -0.0720626 |
| TMSB10 | thymosin beta 10 | -0.0676712 |
| MTAP | methylthioadenosine phosphorylase | -0.0625093 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0589351 |
| TTR | transthyretin | -0.0586453 |
| SP100 | SP100 nuclear antigen | -0.0566984 |
| MT2A | metallothionein 2A | -0.0550931 |
| NAV2 | neuron navigator 2 | -0.0528286 |
| RAD51B | RAD51 paralog B | -0.0504312 |
| RPL23 | ribosomal protein L23 | -0.048407 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0466619 |
| ACTG1 | actin gamma 1 | -0.0456548 |
| FHIT | fragile histidine triad | -0.0455688 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0452323 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0434639 |
| BNC2 | basonuclin 2 | -0.043021 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.041006 |
| EGR1 | early growth response 1 | -0.038861 |
| RPS6 | ribosomal protein S6 | -0.0385533 |
| CALD1 | caldesmon 1 | -0.0381599 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0370509 |
| MYRFL | myelin regulatory factor-like | -0.0357116 |
| RPL30 | ribosomal protein L30 | -0.0355985 |
| RPL32 | ribosomal protein L32 | -0.0354857 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0353338 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0351423 |
| RPLP2 | ribosomal protein, large, P2 | -0.0348539 |
| RPS8 | ribosomal protein S8 | -0.0340728 |
| RPL31 | ribosomal protein L31 | -0.034002 |
| RPLP1 | ribosomal protein, large, P1 | -0.0335344 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0334994 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0334471 |
| RPL19 | ribosomal protein L19 | -0.0331003 |
| FRMD4A | FERM domain containing 4A | -0.0329202 |
| MSH4 | mutS homolog 4 | -0.0317996 |
| INTS6 | integrator complex subunit 6 | -0.0317324 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0309994 |
| AEBP2 | AE binding protein 2 | -0.0305431 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0303695 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.029426 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0289827 |
| RPL34 | ribosomal protein L34 | -0.0285629 |
| ASPH | aspartate beta-hydroxylase | -0.0284386 |
| RPL13A | ribosomal protein L13a | -0.0278105 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.027729 |
| RIGI | RNA sensor RIG-I | -0.027639 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0275008 |
| SMYD3 | SET and MYND domain containing 3 | -0.0271605 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0265261 |
| RPL5 | ribosomal protein L5 | -0.0262591 |
| RPS4X | ribosomal protein S4, X-linked | -0.0262501 |
| RPS21 | ribosomal protein S21 | -0.0259116 |
| RPL35A | ribosomal protein L35a | -0.0258741 |
| S100A2 | S100 calcium binding protein A2 | -0.0257833 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0252575 |
| ANK2 | ankyrin 2, neuronal | -0.0252216 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0242815 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0237437 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0235079 |
| RPL9 | ribosomal protein L9 | -0.0231085 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0227663 |
| RPL36 | ribosomal protein L36 | -0.0226633 |
| ANXA2 | annexin A2 | -0.0223492 |
| GLRX | glutaredoxin (thioltransferase) | -0.0220008 |
| RPS24 | ribosomal protein S24 | -0.0219127 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0218543 |
| VCL | vinculin | -0.0217912 |
| RPS20 | ribosomal protein S20 | -0.0217637 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0214937 |
| RPL38 | ribosomal protein L38 | -0.0212373 |
| AHNAK | AHNAK nucleoprotein | -0.0211236 |
| CDKL1 | cyclin-dependent kinase-like 1 (CDC2-related kinase) | -0.0209167 |
| RPL37A | ribosomal protein L37a | -0.0206646 |
| EGFR | epidermal growth factor receptor | -0.0205006 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0203273 |
| NDRG1 | N-myc downstream regulated 1 | -0.0202051 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0200039 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0199188 |
| KCNMB4 | potassium channel subfamily M regulatory beta subunit 4 | -0.0193902 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -0.0192458 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0192325 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0191695 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | -0.0190942 |
| RPL12 | ribosomal protein L12 | -0.0190167 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0189408 |
| CSTF3 | cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa | -0.018857 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0184247 |
| PGK1 | phosphoglycerate kinase 1 | -0.0182044 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0181271 |
| RASAL2 | RAS protein activator like 2 | -0.0181059 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -0.0180771 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0177232 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0175769 |
| RPS15 | ribosomal protein S15 | -0.0174938 |
| CAST | calpastatin | -0.0173992 |
