| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| B2M | beta-2-microglobulin | 0.115806 |
| VEGFA | vascular endothelial growth factor A | 0.1111 |
| MMP12 | matrix metallopeptidase 12 | 0.100554 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.099689 |
| MT2A | metallothionein 2A | 0.093946 |
| LOXL2 | lysyl oxidase-like 2 | 0.0923931 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0856994 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0839629 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0738106 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0731796 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0716947 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0711161 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0690063 |
| ATP13A3 | ATPase type 13A3 | 0.0641564 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0639143 |
| STC1 | stanniocalcin 1 | 0.0635996 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0600929 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0580592 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0572622 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0553447 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0553376 |
| ARRDC3 | arrestin domain containing 3 | 0.0546034 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0479366 |
| MTSS1 | metastasis suppressor 1 | 0.0473302 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0466576 |
| CD109 | CD109 molecule | 0.0455824 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0451721 |
| AGBL1 | ATP/GTP binding protein-like 1 | 0.0451128 |
| RAI14 | retinoic acid induced 14 | 0.0449894 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0432661 |
| MLPH | melanophilin | 0.0427453 |
| GOLGA4 | golgin A4 | 0.0427335 |
| MMP2 | matrix metallopeptidase 2 | 0.0418315 |
| EML5 | echinoderm microtubule associated protein like 5 | 0.041743 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0378753 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0378232 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.037281 |
| COL5A1 | collagen, type V, alpha 1 | 0.0371535 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0357834 |
| ENO1 | enolase 1, (alpha) | 0.0347723 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0346719 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0343826 |
| MYO9A | myosin IXA | 0.0336346 |
| RTN4 | reticulon 4 | 0.0335189 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0328896 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0322972 |
| COLEC10 | collectin sub-family member 10 (C-type lectin) | 0.0322825 |
| TMF1 | TATA element modulatory factor 1 | 0.0322611 |
| HDAC9 | histone deacetylase 9 | 0.0322013 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0319388 |
| CDCP1 | CUB domain containing protein 1 | 0.0314453 |
| NAV2 | neuron navigator 2 | 0.0313803 |
| ANXA5 | annexin A5 | 0.0310326 |
| FAT1 | FAT atypical cadherin 1 | 0.0308579 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0308244 |
| PFKP | phosphofructokinase, platelet | 0.0305276 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0304658 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0300403 |
| AXL | AXL receptor tyrosine kinase | 0.0299543 |
| MATR3 | matrin 3 | 0.029927 |
| NAV1 | neuron navigator 1 | 0.0294892 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0294173 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0293406 |
| OPTN | optineurin | 0.0289808 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0289091 |
| ADAR | adenosine deaminase, RNA-specific | 0.0287088 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0284545 |
| TMEM165 | transmembrane protein 165 | 0.0282465 |
| TASOR2 | transcription activation suppressor family member 2 | 0.0280188 |
| RND3 | Rho family GTPase 3 | 0.0270924 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0263983 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0262456 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.0260969 |
| SMAD3 | SMAD family member 3 | 0.0259497 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0258039 |
| SLFN5 | schlafen family member 5 | 0.0254994 |
| TPM1 | tropomyosin 1 (alpha) | 0.0251992 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0246191 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0245462 |
| CDH13 | cadherin 13 | 0.0244905 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0244715 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0243558 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0242316 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0237339 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0237198 |
| FOCAD | focadhesin | 0.0236992 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0236455 |
| SYNDIG1 | synapse differentiation inducing 1 | 0.0235216 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0234558 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0232875 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0232722 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0231147 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0230925 |
| PLSCR1 | phospholipid scramblase 1 | 0.0230444 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0229071 |
| YEATS2 | YEATS domain containing 2 | 0.0226679 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0225895 |
| FOSL1 | FOS-like antigen 1 | 0.0225104 |
| CTSB | cathepsin B | 0.0222077 |
| MX1 | MX dynamin-like GTPase 1 | 0.022206 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.119836 |
| VIM | vimentin | -0.103161 |
| FN1 | fibronectin 1 | -0.100378 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0974993 |
| COL1A1 | collagen, type I, alpha 1 | -0.0779187 |
| FRMD4A | FERM domain containing 4A | -0.0730316 |
| COL1A2 | collagen, type I, alpha 2 | -0.0712931 |
| VCL | vinculin | -0.0698794 |
| TMSB10 | thymosin beta 10 | -0.0648924 |
| HLA-B | major histocompatibility complex, class I, B | -0.0505415 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0483347 |
| IER3 | immediate early response 3 | -0.0477694 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0470591 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0460699 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0459052 |
| INTS6 | integrator complex subunit 6 | -0.0451023 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0436922 |
| PTMA | prothymosin, alpha | -0.0429809 |
| PGK1 | phosphoglycerate kinase 1 | -0.0428014 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0415734 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0411802 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0409 |
| ASPH | aspartate beta-hydroxylase | -0.0406829 |
| GLIS3 | GLIS family zinc finger 3 | -0.0400043 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0382856 |
| GNAS | GNAS complex locus | -0.0379317 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0374037 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0371407 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0369866 |
| EGR1 | early growth response 1 | -0.0368627 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.03686 |
| PDE10A | phosphodiesterase 10A | -0.0365152 |
| NDRG1 | N-myc downstream regulated 1 | -0.0358033 |
| TNNC1 | troponin C type 1 (slow) | -0.0357256 |
| ACTG1 | actin gamma 1 | -0.0356299 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0354983 |
| INHBA | inhibin, beta A | -0.0351795 |
| POTEF | POTE ankyrin domain family, member F | -0.0349056 |
| DIAPH3 | diaphanous-related formin 3 | -0.034719 |
| KYNU | kynureninase | -0.0336965 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0333256 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0323276 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0313773 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0302917 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0302601 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0302208 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0298846 |
| COL5A3 | collagen, type V, alpha 3 | -0.0295594 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0290124 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0288011 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.028226 |
| ATXN1 | ataxin 1 | -0.027991 |
| NREP | neuronal regeneration related protein | -0.0279699 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0276774 |
| ACTN1 | actinin, alpha 1 | -0.0274186 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0273666 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0271477 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0269522 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0255788 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0252798 |
| HDLBP | high density lipoprotein binding protein | -0.0252602 |
| TPX2 | TPX2, microtubule-associated | -0.0252576 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0250065 |
| PKM | pyruvate kinase, muscle | -0.0247271 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0246723 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0243724 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0243341 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0243255 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0242108 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0241121 |
| HPCAL1 | hippocalcin-like 1 | -0.0234406 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0232244 |
| AEBP2 | AE binding protein 2 | -0.0231267 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0229572 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.022619 |
| TMEM263 | transmembrane protein 263 | -0.0224166 |
| SHISA5 | shisa family member 5 | -0.0222072 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0221054 |
| SPAG9 | sperm associated antigen 9 | -0.0220154 |
| CALD1 | caldesmon 1 | -0.0220152 |
| ADIPOR2 | adiponectin receptor 2 | -0.022015 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0219905 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0219683 |
| ACTN4 | actinin, alpha 4 | -0.0218884 |
| THBS1 | thrombospondin 1 | -0.0217907 |
| RUNX2 | runt-related transcription factor 2 | -0.0217565 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0217547 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0217264 |
| S100A6 | S100 calcium binding protein A6 | -0.0216261 |
| LRRC23 | leucine rich repeat containing 23 | -0.0215919 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0215453 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0212668 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0210329 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0208558 |
| FHL2 | four and a half LIM domains 2 | -0.0208272 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.020692 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0205904 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0204939 |
| SCFD1 | sec1 family domain containing 1 | -0.0204268 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0203962 |
