Tofacitinib (citrate)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tofacitinib (citrate) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tofacitinib (citrate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VGF VGF nerve growth factor inducible 0.106671
NCKAP5 NCK-associated protein 5 0.0946648
STC1 stanniocalcin 1 0.0907068
PCSK1 proprotein convertase subtilisin/kexin type 1 0.0776143
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 0.0722623
KIF26B kinesin family member 26B 0.0692555
ELL2 elongation factor, RNA polymerase II, 2 0.0637719
IGFBP5 insulin-like growth factor binding protein 5 0.061939
AOPEP aminopeptidase O (putative) 0.0579384
SASH1 SAM and SH3 domain containing 1 0.0575507
SMOC1 SPARC related modular calcium binding 1 0.0560818
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.052091
SMYD3 SET and MYND domain containing 3 0.0466571
H1-0 H1.0 linker histone 0.0444049
NRG1 neuregulin 1 0.0437425
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0426515
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0419999
RNF213 ring finger protein 213 0.0419641
GPC5 glypican 5 0.0418676
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0414619
DGKD diacylglycerol kinase, delta 130kDa 0.0413651
TXNRD1 thioredoxin reductase 1 0.0395662
ASIC2 acid sensing (proton gated) ion channel 2 0.0391076
SVIL supervillin 0.0389386
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0388503
GRIK1 glutamate receptor, ionotropic, kainate 1 0.037886
ARHGAP26 Rho GTPase activating protein 26 0.0376395
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0369751
ENO1 enolase 1, (alpha) 0.0368933
COL22A1 collagen, type XXII, alpha 1 0.0363414
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0357522
ASCL1 achaete-scute family bHLH transcription factor 1 0.0347465
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.033105
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0327986
NAV2 neuron navigator 2 0.032613
TMSB4X thymosin beta 4, X-linked 0.0325047
CALCA calcitonin-related polypeptide alpha 0.0324218
NOVA1 neuro-oncological ventral antigen 1 0.0318594
NDRG1 N-myc downstream regulated 1 0.0309771
FNDC3A fibronectin type III domain containing 3A 0.0304931
GRAMD1B GRAM domain containing 1B 0.0302382
TMEM255B transmembrane protein 255B 0.0300587
KIAA0825 KIAA0825 0.0300571
PDE4D phosphodiesterase 4D, cAMP-specific 0.029759
RIT2 Ras-like without CAAX 2 0.0296975
SCFD2 sec1 family domain containing 2 0.0291093
ANKH ANKH inorganic pyrophosphate transport regulator 0.0289653
MACF1 microtubule-actin crosslinking factor 1 0.0278796
CD99L2 CD99 molecule-like 2 0.0277492
RPH3AL rabphilin 3A-like (without C2 domains) 0.0277114
NBEA neurobeachin 0.0276587
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0272385
ARB2A ARB2 cotranscriptional regulator A 0.027175
ASPH aspartate beta-hydroxylase 0.0269388
PSD3 pleckstrin and Sec7 domain containing 3 0.0269058
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0262075
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.026167
HMGB3 high mobility group box 3 0.0259984
ZBTB7C zinc finger and BTB domain containing 7C 0.0254299
IFI6 interferon, alpha-inducible protein 6 0.0253952
DOCK5 dedicator of cytokinesis 5 0.0253289
GRAMD4 GRAM domain containing 4 0.0247642
EPAS1 endothelial PAS domain protein 1 0.0246674
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 0.0236876
MX2 MX dynamin-like GTPase 2 0.0235436
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0232579
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0232562
ZMYND8 zinc finger, MYND-type containing 8 0.0231832
RTN4 reticulon 4 0.0231326
PAEP progestagen-associated endometrial protein 0.0227102
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0224573
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0223644
RIMS2 regulating synaptic membrane exocytosis 2 0.0222383
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0221569
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 0.0217772
PLSCR1 phospholipid scramblase 1 0.0217595
MYH9 myosin, heavy chain 9, non-muscle 0.0215987
MAN1C1 mannosidase, alpha, class 1C, member 1 0.0213497
CHGB chromogranin B 0.021043
NCOR1 nuclear receptor corepressor 1 0.0210341
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 0.0210254
NF1 neurofibromin 1 0.0208746
SCAPER S-phase cyclin A-associated protein in the ER 0.0207316
NPAS3 neuronal PAS domain protein 3 0.0206618
SRSF4 serine/arginine-rich splicing factor 4 0.0203022
RAB30 RAB30, member RAS oncogene family 0.020188
PTK2 protein tyrosine kinase 2 0.0201202
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0200554
ABLIM3 actin binding LIM protein family, member 3 0.0197538
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0196948
BACE2 beta-site APP-cleaving enzyme 2 0.0194987
STAU2 staufen double-stranded RNA binding protein 2 0.0194355
PRRC2B proline-rich coiled-coil 2B 0.0189679
RNF144A ring finger protein 144A 0.0188912
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0187878
THRAP3 thyroid hormone receptor associated protein 3 0.0185523
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0182513
FKBP9 FK506 binding protein 9, 63 kDa 0.0180111
NAMPT nicotinamide phosphoribosyltransferase 0.0179506
RANBP2 RAN binding protein 2 0.0178986

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.117412
TENM1 teneurin transmembrane protein 1 -0.112533
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.111806
NALF1 NALCN channel auxiliary factor 1 -0.110119
GPC6 glypican 6 -0.0863223
CENPF centromere protein F, 350/400kDa -0.0669354
TOP2A topoisomerase (DNA) II alpha 170kDa -0.063639
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0576523
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0564341
DTNA dystrobrevin, alpha -0.054343
KLHL29 kelch-like family member 29 -0.0506757
RPS6 ribosomal protein S6 -0.0500565
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0459654
RPS8 ribosomal protein S8 -0.0458948
RPL37A ribosomal protein L37a -0.0429907
FTL ferritin, light polypeptide -0.0423074
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0401924
TTC19 tetratricopeptide repeat domain 19 -0.0397685
RPL11 ribosomal protein L11 -0.0392014
HOMER1 homer scaffolding protein 1 -0.0391067
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.038122
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0380286
RPS3 ribosomal protein S3 -0.0370903
RPLP1 ribosomal protein, large, P1 -0.0368947
EGR1 early growth response 1 -0.0365389
NFIA nuclear factor I/A -0.036198
CNKSR3 CNKSR family member 3 -0.0361449
ZNF292 zinc finger protein 292 -0.0351866
RPL23 ribosomal protein L23 -0.0342962
RPL8 ribosomal protein L8 -0.0337942
RPL5 ribosomal protein L5 -0.0329987
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0325009
RPL37 ribosomal protein L37 -0.0318604
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0316598
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0316396
RPS25 ribosomal protein S25 -0.0315237
TRA2A transformer 2 alpha homolog (Drosophila) -0.0309394
FGF14 fibroblast growth factor 14 -0.030477
RPLP0 ribosomal protein, large, P0 -0.0302678
RAB2A RAB2A, member RAS oncogene family -0.0299517
ESRRG estrogen-related receptor gamma -0.0295944
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0295511
RPL31 ribosomal protein L31 -0.0294368
ACTG1 actin gamma 1 -0.02943
TENT5A terminal nucleotidyltransferase 5A -0.0291091
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.02909
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.028679
RPS27 ribosomal protein S27 -0.0284925
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0284609
PCBP3 poly(rC) binding protein 3 -0.0274799
CHD7 chromodomain helicase DNA binding protein 7 -0.0269803
RPL4 ribosomal protein L4 -0.026947
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0268998
MIS18BP1 MIS18 binding protein 1 -0.0268992
RPS19 ribosomal protein S19 -0.0268866
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0266921
RPS16 ribosomal protein S16 -0.026582
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.02627
SEPTIN7 septin 7 -0.0261555
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0259677
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0256436
TPT1 tumor protein, translationally-controlled 1 -0.025514
RPS23 ribosomal protein S23 -0.0254157
RPL34 ribosomal protein L34 -0.0253695
RACK1 receptor for activated C kinase 1 -0.0252181
MKI67 marker of proliferation Ki-67 -0.0247476
EIF1 eukaryotic translation initiation factor 1 -0.024721
RORA RAR-related orphan receptor A -0.0244107
RPL35 ribosomal protein L35 -0.0241955
RPL32 ribosomal protein L32 -0.0241876
SMC4 structural maintenance of chromosomes 4 -0.0241298
CA8 carbonic anhydrase VIII -0.0239988
TPST1 tyrosylprotein sulfotransferase 1 -0.0238523
FOXC1 forkhead box C1 -0.0237229
CUL3 cullin 3 -0.023319
NKTR natural killer cell triggering receptor -0.0230706
ADGRL2 adhesion G protein-coupled receptor L2 -0.0230531
CADM1 cell adhesion molecule 1 -0.0230514
FOXO3 forkhead box O3 -0.0227929
ONECUT2 one cut homeobox 2 -0.0226922
ATP5F1E ATP synthase F1 subunit epsilon -0.0225201
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -0.0224429
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0224324
AGBL4 ATP/GTP binding protein-like 4 -0.0223246
MCTP1 multiple C2 domains, transmembrane 1 -0.0222793
ERO1B endoplasmic reticulum oxidoreductase 1 beta -0.0222009
YBX1 Y box binding protein 1 -0.0220347
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 -0.0219924
RPL7 ribosomal protein L7 -0.0219833
HM13 histocompatibility (minor) 13 -0.0219767
RPS24 ribosomal protein S24 -0.0219656
RAD21 RAD21 homolog (S. pombe) -0.0219404
TPD52 tumor protein D52 -0.0219049
RPS17 ribosomal protein S17 -0.0218875
SNTG1 syntrophin, gamma 1 -0.0218743
APP amyloid beta (A4) precursor protein -0.0217659
RPL36 ribosomal protein L36 -0.021682
RYBP RING1 and YY1 binding protein -0.02163
MCL1 myeloid cell leukemia 1 -0.0216108
RPL7A ribosomal protein L7a -0.0214854