Tofacitinib (citrate)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tofacitinib (citrate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tofacitinib (citrate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.191161
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.121702
IGFBP3 insulin-like growth factor binding protein 3 0.0844111
HDAC9 histone deacetylase 9 0.0843004
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0731959
FNDC3B fibronectin type III domain containing 3B 0.0579832
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0564845
RUNX1 runt-related transcription factor 1 0.0501685
FRMD4A FERM domain containing 4A 0.0501063
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0473605
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.046653
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0456091
CD44 CD44 molecule (Indian blood group) 0.0451776
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0411671
FRMD5 FERM domain containing 5 0.0389384
NPAS2 neuronal PAS domain protein 2 0.037856
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0374316
CTSB cathepsin B 0.0371674
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0369434
FLNA filamin A, alpha 0.0354467
OSBPL10 oxysterol binding protein-like 10 0.0339639
VMP1 vacuole membrane protein 1 0.0329913
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0325871
RHOA ras homolog family member A 0.0322056
EHBP1 EH domain binding protein 1 0.0317216
MELTF melanotransferrin 0.0313957
HSPA8 heat shock 70kDa protein 8 0.0310406
TENM3 teneurin transmembrane protein 3 0.0310383
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0304212
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0298536
SVIL supervillin 0.0294398
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0293524
TPM3 tropomyosin 3 0.0292653
IFI16 interferon, gamma-inducible protein 16 0.0288284
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0279515
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0277057
PRRC2B proline-rich coiled-coil 2B 0.0276358
ZBTB20 zinc finger and BTB domain containing 20 0.0267238
EEF2 eukaryotic translation elongation factor 2 0.0266536
OPHN1 oligophrenin 1 0.0264679
BACE2 beta-site APP-cleaving enzyme 2 0.0256876
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0255261
CD59 CD59 molecule, complement regulatory protein 0.0250997
CNKSR3 CNKSR family member 3 0.0249784
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.024878
PYGL phosphorylase, glycogen, liver 0.0248715
IL1RAP interleukin 1 receptor accessory protein 0.0244929
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0241329
ANGPTL4 angiopoietin-like 4 0.0241153
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.023729
RASAL2 RAS protein activator like 2 0.023672
ENO1 enolase 1, (alpha) 0.0236064
LPP LIM domain containing preferred translocation partner in lipoma 0.0235573
AGO2 argonaute RISC catalytic component 2 0.0235342
AKAP13 A kinase (PRKA) anchor protein 13 0.02343
NPC1 Niemann-Pick disease, type C1 0.0233009
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0232236
LAMB1 laminin, beta 1 0.0231749
UBASH3B ubiquitin associated and SH3 domain containing B 0.0231146
DIAPH2 diaphanous-related formin 2 0.0228433
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0227646
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0225228
AATF apoptosis antagonizing transcription factor 0.0225172
MCL1 myeloid cell leukemia 1 0.0225162
PCBP3 poly(rC) binding protein 3 0.0224709
DOCK5 dedicator of cytokinesis 5 0.0223857
SLC39A11 solute carrier family 39, member 11 0.0222005
SQSTM1 sequestosome 1 0.0219714
PTPRG protein tyrosine phosphatase, receptor type, G 0.0212188
MAML3 mastermind-like 3 (Drosophila) 0.0208641
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0207257
TM4SF1 transmembrane 4 L six family member 1 0.0205316
TRIO trio Rho guanine nucleotide exchange factor 0.0203533
PLSCR1 phospholipid scramblase 1 0.0202952
PSD3 pleckstrin and Sec7 domain containing 3 0.0202892
SRRM2 serine/arginine repetitive matrix 2 0.0201071
TRIM44 tripartite motif containing 44 0.0199883
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0198897
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0198868
TRIP12 thyroid hormone receptor interactor 12 0.0197254
KYNU kynureninase 0.0196147
ZC3H7B zinc finger CCCH-type containing 7B 0.0195272
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0193841
FTH1 ferritin, heavy polypeptide 1 0.0192738
EP300 E1A binding protein p300 0.0190875
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0189205
RABGAP1L RAB GTPase activating protein 1-like 0.0188615
CEP250 centrosomal protein 250kDa 0.0187452
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.018511
IQGAP1 IQ motif containing GTPase activating protein 1 0.0184558
DIAPH1 diaphanous-related formin 1 0.0181217
NFE2L1 nuclear factor, erythroid 2-like 1 0.0180597
AKAP6 A kinase (PRKA) anchor protein 6 0.0180259
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0179817
TXNRD1 thioredoxin reductase 1 0.017968
CLIC4 chloride intracellular channel 4 0.0177959
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.017765
MYH9 myosin, heavy chain 9, non-muscle 0.0177555
ECPAS Ecm29 proteasome adaptor and scaffold 0.0176573
LINGO2 leucine rich repeat and Ig domain containing 2 0.0175202

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.122587
VIM vimentin -0.099956
NLGN1 neuroligin 1 -0.0936133
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0881181
LSAMP limbic system-associated membrane protein -0.08015
FN1 fibronectin 1 -0.0724207
TMSB10 thymosin beta 10 -0.061342
GOLGA4 golgin A4 -0.0610028
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0545626
RPL23 ribosomal protein L23 -0.0542539
PTMA prothymosin, alpha -0.0535735
PMEL premelanosome protein -0.0493552
RPS6 ribosomal protein S6 -0.0462615
FTL ferritin, light polypeptide -0.0449942
RPLP1 ribosomal protein, large, P1 -0.0406679
NRG3 neuregulin 3 -0.0402898
CENPF centromere protein F, 350/400kDa -0.0393658
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0370578
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0345947
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0343065
RPL35A ribosomal protein L35a -0.0341007
PGK1 phosphoglycerate kinase 1 -0.0338216
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0336544
CTSD cathepsin D -0.0334316
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -0.0332254
RPS21 ribosomal protein S21 -0.0328516
GARS1 glycyl-tRNA synthetase 1 -0.0320755
MT2A metallothionein 2A -0.031394
KMT2E lysine (K)-specific methyltransferase 2E -0.0304688
GLS2 glutaminase 2 (liver, mitochondrial) -0.0303817
RPLP2 ribosomal protein, large, P2 -0.0301294
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0301141
RPL32 ribosomal protein L32 -0.0300825
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0299315
RPS8 ribosomal protein S8 -0.029776
TKT transketolase -0.0297727
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0293768
MBNL1 muscleblind-like splicing regulator 1 -0.0285188
POTEF POTE ankyrin domain family, member F -0.0278756
RPS24 ribosomal protein S24 -0.0276101
CYB5R3 cytochrome b5 reductase 3 -0.0272254
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0271262
SPAG9 sperm associated antigen 9 -0.0264034
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0262715
LCORL ligand dependent nuclear receptor corepressor-like -0.0262066
NAMPT nicotinamide phosphoribosyltransferase -0.0261298
CCND1 cyclin D1 -0.025891
CBX3 chromobox homolog 3 -0.0257611
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0251812
PRAME preferentially expressed antigen in melanoma -0.0250993
HMGA1 high mobility group AT-hook 1 -0.0250491
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0248979
RPL8 ribosomal protein L8 -0.0248761
S100A9 S100 calcium binding protein A9 -0.0247094
RPL19 ribosomal protein L19 -0.024658
CADM1 cell adhesion molecule 1 -0.0246539
BCAS3 breast carcinoma amplified sequence 3 -0.0245999
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.024408
RPS23 ribosomal protein S23 -0.0242876
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0239795
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0238412
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0238375
PDIA3 protein disulfide isomerase family A, member 3 -0.0237682
TRA2A transformer 2 alpha homolog (Drosophila) -0.0237173
TSC22D2 TSC22 domain family, member 2 -0.0236852
OLA1 Obg-like ATPase 1 -0.0234744
RPS19 ribosomal protein S19 -0.023367
MSI2 musashi RNA-binding protein 2 -0.023271
RPS14 ribosomal protein S14 -0.0232593
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.023198
VDAC1 voltage-dependent anion channel 1 -0.0229563
TOB2 transducer of ERBB2, 2 -0.0229484
ANLN anillin, actin binding protein -0.0228528
MORF4L2 mortality factor 4 like 2 -0.0227057
RAB7A RAB7A, member RAS oncogene family -0.0226968
MKI67 marker of proliferation Ki-67 -0.022688
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0226773
WDR45B WD repeat domain 45B -0.0226327
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0226188
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0225877
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.022541
BZW2 basic leucine zipper and W2 domains 2 -0.0223424
CA8 carbonic anhydrase VIII -0.022082
WDPCP WD repeat containing planar cell polarity effector -0.0218823
LAMP2 lysosomal-associated membrane protein 2 -0.0218725
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0218073
TPX2 TPX2, microtubule-associated -0.0218028
LRMDA leucine rich melanocyte differentiation associated -0.0216992
SKIC3 SKI3 subunit of superkiller complex -0.0214036
IFI6 interferon, alpha-inducible protein 6 -0.0212439
RPS16 ribosomal protein S16 -0.0210778
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0210599
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0210046
TUBB tubulin, beta class I -0.0209117
LDHA lactate dehydrogenase A -0.0207175
MT1X metallothionein 1X -0.0206542
AKAP10 A kinase (PRKA) anchor protein 10 -0.0206387
FMN1 formin 1 -0.0206311
PCBP2 poly(rC) binding protein 2 -0.0205161
KLHL24 kelch-like family member 24 -0.0204885