| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.109293 |
| VEGFA | vascular endothelial growth factor A | 0.106057 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0811565 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0764063 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0714457 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0530401 |
| HIP1 | huntingtin interacting protein 1 | 0.0515807 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0506316 |
| TMEM165 | transmembrane protein 165 | 0.0458796 |
| GOLGB1 | golgin B1 | 0.0450358 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0440073 |
| NRXN3 | neurexin 3 | 0.0407748 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.040052 |
| RNF145 | ring finger protein 145 | 0.0398495 |
| ARRDC3 | arrestin domain containing 3 | 0.0396005 |
| EFNA5 | ephrin-A5 | 0.0385377 |
| LOXL2 | lysyl oxidase-like 2 | 0.036332 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0362834 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0359588 |
| CDK6 | cyclin-dependent kinase 6 | 0.0359406 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | 0.035854 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0357819 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0353891 |
| FAM13A | family with sequence similarity 13, member A | 0.0344157 |
| RAI14 | retinoic acid induced 14 | 0.0332419 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0325124 |
| NAV1 | neuron navigator 1 | 0.0325097 |
| SEPTIN9 | septin 9 | 0.0324378 |
| COL5A1 | collagen, type V, alpha 1 | 0.0322717 |
| MRTFA | myocardin related transcription factor A | 0.0321921 |
| RND3 | Rho family GTPase 3 | 0.0317318 |
| PTK2 | protein tyrosine kinase 2 | 0.0311605 |
| YTHDC1 | YTH domain containing 1 | 0.0310975 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0310557 |
| YEATS2 | YEATS domain containing 2 | 0.0308918 |
| CSMD2 | CUB and Sushi multiple domains 2 | 0.0307719 |
| FAM13B | family with sequence similarity 13, member B | 0.0307004 |
| COPA | coatomer protein complex, subunit alpha | 0.0305134 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0304623 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0295731 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0294369 |
| CD44 | CD44 molecule (Indian blood group) | 0.0293561 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0293398 |
| GLIS3 | GLIS family zinc finger 3 | 0.0289076 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0288079 |
| CAB39 | calcium binding protein 39 | 0.0282209 |
| CACNA1C | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.0280346 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0276636 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | 0.0272479 |
| VMP1 | vacuole membrane protein 1 | 0.0270114 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0268928 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0266841 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0266381 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0265406 |
| FMNL2 | formin-like 2 | 0.02599 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0257127 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0256059 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0253629 |
| COG5 | component of oligomeric golgi complex 5 | 0.0253545 |
| CDH13 | cadherin 13 | 0.0251481 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.025076 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0249189 |
| MLPH | melanophilin | 0.0248528 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0247761 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0245055 |
| IL6 | interleukin 6 | 0.0243421 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0242486 |
| AOPEP | aminopeptidase O (putative) | 0.0241506 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.02398 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0236625 |
| UBXN4 | UBX domain protein 4 | 0.0233977 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0233907 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0233444 |
| COG6 | component of oligomeric golgi complex 6 | 0.0232481 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.023214 |
| SSH1 | slingshot protein phosphatase 1 | 0.0231736 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0230597 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0230113 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0227112 |
| AHDC1 | AT hook, DNA binding motif, containing 1 | 0.0225572 |
| OXR1 | oxidation resistance 1 | 0.0225007 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0222961 |
| FRMD4A | FERM domain containing 4A | 0.0221482 |
| RUNX1 | runt-related transcription factor 1 | 0.022098 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0220572 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0220097 |
| TBC1D22A | TBC1 domain family, member 22A | 0.021843 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0216684 |
| TRIM33 | tripartite motif containing 33 | 0.0215281 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0215249 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0214859 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0214172 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0212182 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0211765 |
| APP | amyloid beta (A4) precursor protein | 0.0211685 |
| JAK1 | Janus kinase 1 | 0.0211641 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0210951 |
| OSBP | oxysterol binding protein | 0.0210525 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0209803 |
| KYNU | kynureninase | 0.0209706 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.253045 |
| TMSB10 | thymosin beta 10 | -0.207212 |
| VIM | vimentin | -0.133938 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.131583 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.122058 |
| COL1A2 | collagen, type I, alpha 2 | -0.117004 |
| SDC4 | syndecan 4 | -0.101555 |
| LDHA | lactate dehydrogenase A | -0.0874053 |
| UBC | ubiquitin C | -0.0704789 |
| MT2A | metallothionein 2A | -0.0697713 |
| CALD1 | caldesmon 1 | -0.0677502 |
| LOX | lysyl oxidase | -0.0654249 |
| POTEF | POTE ankyrin domain family, member F | -0.0645985 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0639411 |
| COL1A1 | collagen, type I, alpha 1 | -0.0607483 |
| PRSS23 | protease, serine, 23 | -0.0587103 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0520587 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0488544 |
| ENO1 | enolase 1, (alpha) | -0.0478695 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0454659 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0446811 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.044011 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0433849 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0433679 |
| ACTG1 | actin gamma 1 | -0.0432882 |
| SEPTIN7 | septin 7 | -0.042966 |
| PTMA | prothymosin, alpha | -0.0427242 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0425147 |
| MT1X | metallothionein 1X | -0.0416931 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0416704 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0403753 |
| CENPF | centromere protein F, 350/400kDa | -0.0396871 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0392001 |
| VCL | vinculin | -0.0390954 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0386233 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0373634 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0364031 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0364009 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0357455 |
| RPS24 | ribosomal protein S24 | -0.0355045 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0345273 |
| HDLBP | high density lipoprotein binding protein | -0.0332177 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0329143 |
| COL5A2 | collagen, type V, alpha 2 | -0.0328963 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0327668 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0325069 |
| ANXA5 | annexin A5 | -0.0323631 |
| CCNI | cyclin I | -0.0322424 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0322293 |
| RRBP1 | ribosome binding protein 1 | -0.032225 |
| RPL23 | ribosomal protein L23 | -0.031843 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0313318 |
| HLA-B | major histocompatibility complex, class I, B | -0.0312968 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0309148 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0300496 |
| RPL32 | ribosomal protein L32 | -0.0299308 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0299052 |
| QKI | QKI, KH domain containing, RNA binding | -0.0298448 |
| S100A6 | S100 calcium binding protein A6 | -0.0283806 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0282426 |
| CTSB | cathepsin B | -0.0280463 |
| RPL28 | ribosomal protein L28 | -0.0279773 |
| ZNF207 | zinc finger protein 207 | -0.0278464 |
| WTAP | Wilms tumor 1 associated protein | -0.0278221 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.027735 |
| SRPK2 | SRSF protein kinase 2 | -0.0276707 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0274517 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.0274361 |
| RPS27A | ribosomal protein S27a | -0.0273982 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0273236 |
| CTSD | cathepsin D | -0.027255 |
| CALU | calumenin | -0.0269758 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0268204 |
| TXNIP | thioredoxin interacting protein | -0.0264503 |
| PLCB4 | phospholipase C, beta 4 | -0.0263892 |
| RPS11 | ribosomal protein S11 | -0.0262011 |
| MCL1 | myeloid cell leukemia 1 | -0.0261193 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0260239 |
| MTPN | myotrophin | -0.0258816 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0258578 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | -0.0257696 |
| GNAS | GNAS complex locus | -0.0254346 |
| AHNAK | AHNAK nucleoprotein | -0.0253777 |
| EGR1 | early growth response 1 | -0.0253005 |
| SEPTIN11 | septin 11 | -0.0251149 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0251028 |
| RPL37A | ribosomal protein L37a | -0.0250795 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0249666 |
| RPLP0 | ribosomal protein, large, P0 | -0.0246479 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | -0.0246291 |
| PDE10A | phosphodiesterase 10A | -0.024375 |
| SPAG9 | sperm associated antigen 9 | -0.0242566 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0242422 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0240461 |
| NOP58 | NOP58 ribonucleoprotein | -0.0239918 |
| S100A9 | S100 calcium binding protein A9 | -0.0238409 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0238359 |
| H3-3B | H3.3 histone B | -0.0238263 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.0237474 |
| SGCB | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | -0.0237006 |
