Tofacitinib (citrate)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tofacitinib (citrate) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tofacitinib (citrate)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0836266
FTH1 ferritin, heavy polypeptide 1 0.0801563
ZSWIM6 zinc finger, SWIM-type containing 6 0.070822
FNDC3B fibronectin type III domain containing 3B 0.0696099
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0640626
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0627881
SAMD4A sterile alpha motif domain containing 4A 0.0607613
SVIL supervillin 0.0605753
IGFBP3 insulin-like growth factor binding protein 3 0.0540689
INTS6 integrator complex subunit 6 0.0494483
BICD1 bicaudal D homolog 1 (Drosophila) 0.0489391
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0438573
PALM2AKAP2 PALM2 and AKAP2 fusion 0.042937
HMGA2 high mobility group AT-hook 2 0.042843
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.04174
FMNL2 formin-like 2 0.0399784
MACF1 microtubule-actin crosslinking factor 1 0.0396052
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0383631
AHNAK2 AHNAK nucleoprotein 2 0.0376987
NPAS2 neuronal PAS domain protein 2 0.0375234
MYH9 myosin, heavy chain 9, non-muscle 0.037316
SH3KBP1 SH3-domain kinase binding protein 1 0.0360032
CLIC4 chloride intracellular channel 4 0.0359746
IRAK2 interleukin-1 receptor-associated kinase 2 0.0358222
RAI14 retinoic acid induced 14 0.0358073
BCAR3 breast cancer anti-estrogen resistance 3 0.0353355
COL5A1 collagen, type V, alpha 1 0.0346266
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0335458
PRR16 proline rich 16 0.0333196
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0321374
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0321184
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0311689
ANXA2 annexin A2 0.0311533
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0297079
AKAP12 A kinase (PRKA) anchor protein 12 0.029622
CAPRIN2 caprin family member 2 0.0293074
ITPRID2 ITPR interacting domain containing 2 0.0292825
ENO1 enolase 1, (alpha) 0.0291182
TBC1D22A TBC1 domain family, member 22A 0.0287477
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.028631
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0282587
SKIL SKI-like proto-oncogene 0.0282147
THSD4 thrombospondin, type I, domain containing 4 0.0279302
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0275674
FNDC3A fibronectin type III domain containing 3A 0.0273354
BHLHE40 basic helix-loop-helix family, member e40 0.0272475
EXT1 exostosin glycosyltransferase 1 0.0267671
PCED1B PC-esterase domain containing 1B 0.0267006
ABR active BCR-related 0.0264505
HPCAL1 hippocalcin-like 1 0.026416
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0262214
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0261491
NIBAN2 niban apoptosis regulator 2 0.0258559
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.0258439
KIAA1671 KIAA1671 0.0257739
ASPH aspartate beta-hydroxylase 0.0257341
PKM pyruvate kinase, muscle 0.0251211
PBX3 pre-B-cell leukemia homeobox 3 0.0250895
UTRN utrophin 0.0249154
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 0.0246677
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0246089
GATAD2B GATA zinc finger domain containing 2B 0.0245012
MAP1B microtubule-associated protein 1B 0.0242086
CYTH1 cytohesin 1 0.0239301
IL1RAP interleukin 1 receptor accessory protein 0.0237104
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0236133
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0236107
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0235133
CMIP c-Maf inducing protein 0.0234445
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0233706
LOC112694756 uncharaterized LOC112694756 0.0232236
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0231841
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0231121
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0226904
ANGPTL4 angiopoietin-like 4 0.0226287
SMAD3 SMAD family member 3 0.0225885
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0222837
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.022057
PARD3 par-3 family cell polarity regulator 0.0218596
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0218585
PRSS23 protease, serine, 23 0.0216151
KLF3 Kruppel-like factor 3 (basic) 0.0215815
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0214124
LAMA5 laminin, alpha 5 0.0213788
PRKCA protein kinase C, alpha 0.0213699
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.021114
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.020944
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0209334
EEF2 eukaryotic translation elongation factor 2 0.0208321
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0207257
RBM5 RNA binding motif protein 5 0.0206601
AREG amphiregulin 0.0205579
ITGB4 integrin, beta 4 0.0205052
RNASEH2A ribonuclease H2, subunit A 0.0204242
NT5E 5'-nucleotidase, ecto (CD73) 0.0204238
AHNAK AHNAK nucleoprotein 0.0203531
LGALS12 lectin, galactoside-binding, soluble, 12 0.0202002
ANXA4 annexin A4 0.0200531
PODXL podocalyxin-like 0.0200027
OXSR1 oxidative stress responsive 1 0.0198648

decreased expression

Symbol Name Standardized Value
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.125571
PTMA prothymosin, alpha -0.107627
GOLGA4 golgin A4 -0.0996211
CENPF centromere protein F, 350/400kDa -0.0815817
SMYD3 SET and MYND domain containing 3 -0.0811813
VIM vimentin -0.0797132
TPX2 TPX2, microtubule-associated -0.0746075
TXNRD1 thioredoxin reductase 1 -0.0727026
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0681893
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0674343
ANLN anillin, actin binding protein -0.0671462
YBX3 Y box binding protein 3 -0.0661241
NAP1L1 nucleosome assembly protein 1-like 1 -0.0622085
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0601318
SMC4 structural maintenance of chromosomes 4 -0.0582496
WAC WW domain containing adaptor with coiled-coil -0.057306
CKAP2 cytoskeleton associated protein 2 -0.0571767
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.057023
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0545854
RBM39 RNA binding motif protein 39 -0.054551
ANKRD28 ankyrin repeat domain 28 -0.0493274
CXCL8 chemokine (C-X-C motif) ligand 8 -0.048833
NUP58 nucleoporin 58 -0.0484235
PDE4D phosphodiesterase 4D, cAMP-specific -0.0478816
PNISR PNN-interacting serine/arginine-rich protein -0.0462011
CLTC clathrin, heavy chain (Hc) -0.0458286
PUM2 pumilio RNA-binding family member 2 -0.0457355
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0454349
APOLD1 apolipoprotein L domain containing 1 -0.0453112
NF1 neurofibromin 1 -0.0446103
PRR11 proline rich 11 -0.0446055
ITCH itchy E3 ubiquitin protein ligase -0.0444739
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0436698
KIF4A kinesin family member 4A -0.0436243
EIF1 eukaryotic translation initiation factor 1 -0.043052
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0429705
ATM ATM serine/threonine kinase -0.0425446
GNAS GNAS complex locus -0.0425412
ZNF609 zinc finger protein 609 -0.0424798
DIAPH3 diaphanous-related formin 3 -0.0412223
MBNL1 muscleblind-like splicing regulator 1 -0.0407661
SPAG9 sperm associated antigen 9 -0.0401536
NKTR natural killer cell triggering receptor -0.0400808
VDAC1 voltage-dependent anion channel 1 -0.0399824
DEK DEK proto-oncogene -0.0398597
GOLT1B golgi transport 1B -0.0397652
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0393291
PICALM phosphatidylinositol binding clathrin assembly protein -0.0390028
MKI67 marker of proliferation Ki-67 -0.0386801
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0386353
ZNF292 zinc finger protein 292 -0.0381031
CANX calnexin -0.0379199
ECT2 epithelial cell transforming 2 -0.0377351
MORF4L2 mortality factor 4 like 2 -0.0377198
GAS2L3 growth arrest-specific 2 like 3 -0.0376159
TM9SF2 transmembrane 9 superfamily member 2 -0.0373945
SGO2 shugoshin 2 -0.0370731
TBC1D5 TBC1 domain family, member 5 -0.0365821
CKAP5 cytoskeleton associated protein 5 -0.0364474
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0363361
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0360523
MRE11 MRE11 homolog, double strand break repair nuclease -0.0359838
KIF5B kinesin family member 5B -0.0353072
CEP57 centrosomal protein 57kDa -0.0344023
SOD2 superoxide dismutase 2, mitochondrial -0.0343422
NOP58 NOP58 ribonucleoprotein -0.0342395
KMT2A lysine (K)-specific methyltransferase 2A -0.034188
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.034004
MIS18BP1 MIS18 binding protein 1 -0.0338205
IARS1 isoleucyl-tRNA synthetase 1 -0.0331202
KIAA1328 KIAA1328 -0.0329045
TCERG1 transcription elongation regulator 1 -0.0328512
SKIC3 SKI3 subunit of superkiller complex -0.0325044
SNX14 sorting nexin 14 -0.0317883
SSH2 slingshot protein phosphatase 2 -0.0309802
CCDC88A coiled-coil domain containing 88A -0.0309481
RB1CC1 RB1-inducible coiled-coil 1 -0.0308767
CLINT1 clathrin interactor 1 -0.0306728
CALU calumenin -0.0305221
ARHGAP5 Rho GTPase activating protein 5 -0.03047
LMNA lamin A/C -0.0302272
INVS inversin -0.0300753
TMCC1 transmembrane and coiled-coil domain family 1 -0.0300313
TAS2R14 taste receptor, type 2, member 14 -0.03003
KIAA1958 KIAA1958 -0.0299595
RPLP1 ribosomal protein, large, P1 -0.029882
SRP54 signal recognition particle 54kDa -0.029879
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0297535
PHF20 PHD finger protein 20 -0.0295111
TMEM245 transmembrane protein 245 -0.029442
CHD1 chromodomain helicase DNA binding protein 1 -0.0294042
NSD2 nuclear receptor binding SET domain protein 2 -0.0291515
SRPK2 SRSF protein kinase 2 -0.0290852
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0288123
KPNB1 karyopherin (importin) beta 1 -0.0287114
RSF1 remodeling and spacing factor 1 -0.0286952
OGA O-GlcNAcase -0.0286618
TPT1 tumor protein, translationally-controlled 1 -0.0286421
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0283929
NBEAL1 neurobeachin-like 1 -0.0280906