| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.253335 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.132259 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.100084 |
| BCL2L1 | BCL2-like 1 | 0.096429 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0844964 |
| VMP1 | vacuole membrane protein 1 | 0.0825032 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0780789 |
| RPS6 | ribosomal protein S6 | 0.069371 |
| RPS3 | ribosomal protein S3 | 0.0633652 |
| MATR3 | matrin 3 | 0.0623254 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0618033 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0603751 |
| GOLGA4 | golgin A4 | 0.0549418 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0509183 |
| MED13L | mediator complex subunit 13-like | 0.0508711 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0504782 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0462373 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0444136 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0428033 |
| PNN | pinin, desmosome associated protein | 0.041409 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0405408 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.040482 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.040262 |
| RPL26 | ribosomal protein L26 | 0.0394788 |
| VEGFA | vascular endothelial growth factor A | 0.0391992 |
| DSPP | dentin sialophosphoprotein | 0.0386495 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0375261 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0372313 |
| BRD2 | bromodomain containing 2 | 0.0366562 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0358642 |
| RPS12 | ribosomal protein S12 | 0.0354223 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0341719 |
| CCNL1 | cyclin L1 | 0.0341537 |
| YBX1 | Y box binding protein 1 | 0.0337535 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0332124 |
| NEK7 | NIMA-related kinase 7 | 0.0328675 |
| SET | SET nuclear proto-oncogene | 0.0319352 |
| CALR | calreticulin | 0.031755 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.031548 |
| MACC1 | metastasis associated in colon cancer 1 | 0.031409 |
| RTN4 | reticulon 4 | 0.0312286 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0310339 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0307279 |
| TPM3 | tropomyosin 3 | 0.0306186 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0302898 |
| LMTK2 | lemur tyrosine kinase 2 | 0.0300225 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0296964 |
| KIF5B | kinesin family member 5B | 0.0295294 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0294286 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.029176 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0288608 |
| RPS2 | ribosomal protein S2 | 0.0288448 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0288308 |
| FTL | ferritin, light polypeptide | 0.0286826 |
| FAT1 | FAT atypical cadherin 1 | 0.0284119 |
| RHOA | ras homolog family member A | 0.0282579 |
| DIAPH1 | diaphanous-related formin 1 | 0.0281582 |
| RPL3 | ribosomal protein L3 | 0.0281222 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0280466 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0278156 |
| TFG | TRK-fused gene | 0.0277649 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0277452 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.027735 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0276691 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0276445 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0272983 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0272827 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0272805 |
| ANXA11 | annexin A11 | 0.0271974 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.026973 |
| RPS18 | ribosomal protein S18 | 0.026971 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0267312 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0266199 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0265914 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0264246 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0263595 |
| RIOK3 | RIO kinase 3 | 0.0262719 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.025999 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0258547 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0257323 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0256572 |
| RPL11 | ribosomal protein L11 | 0.0254331 |
| PCBP2 | poly(rC) binding protein 2 | 0.0253115 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0252252 |
| TXNIP | thioredoxin interacting protein | 0.02522 |
| TXNRD1 | thioredoxin reductase 1 | 0.0251266 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0246726 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0244605 |
| PHIP | pleckstrin homology domain interacting protein | 0.0243568 |
| EZR | ezrin | 0.0242955 |
| POTEF | POTE ankyrin domain family, member F | 0.0242782 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0241645 |
| NCKAP1 | NCK-associated protein 1 | 0.0239009 |
| CCNY | cyclin Y | 0.0238248 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0237513 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | 0.0236393 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0236028 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0235968 |
| ARRDC3 | arrestin domain containing 3 | 0.0235371 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.023207 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MAML2 | mastermind-like 2 (Drosophila) | -0.0993754 |
| PTMA | prothymosin, alpha | -0.0958734 |
| TMSB10 | thymosin beta 10 | -0.093816 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0822652 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0776947 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0772732 |
| GNAS | GNAS complex locus | -0.0697438 |
| TMEM123 | transmembrane protein 123 | -0.063517 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0630065 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0564319 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0542063 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0541735 |
| IER3 | immediate early response 3 | -0.0535559 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0523649 |
| EHBP1 | EH domain binding protein 1 | -0.0502785 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0496629 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0492828 |
| MX2 | MX dynamin-like GTPase 2 | -0.0478755 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0478085 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0473829 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0473233 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0463199 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0449235 |
| RNF213 | ring finger protein 213 | -0.0446061 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0441021 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0437796 |
| CCND1 | cyclin D1 | -0.0430559 |
| SP100 | SP100 nuclear antigen | -0.0413515 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.0393546 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0378471 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0376247 |
| SERINC5 | serine incorporator 5 | -0.0372593 |
| S100A6 | S100 calcium binding protein A6 | -0.0370112 |
| PLSCR1 | phospholipid scramblase 1 | -0.0367799 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0366524 |
| RIGI | RNA sensor RIG-I | -0.0362363 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0359076 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0352847 |
| EGR1 | early growth response 1 | -0.0351167 |
| TRIM56 | tripartite motif containing 56 | -0.0344493 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0343106 |
| HLA-B | major histocompatibility complex, class I, B | -0.0327818 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0326914 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0321649 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0321491 |
| SQSTM1 | sequestosome 1 | -0.0320118 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0318858 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0313732 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0310461 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.030511 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0298438 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0298434 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.0294932 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0293785 |
| ZNF217 | zinc finger protein 217 | -0.0293615 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0292102 |
| PERP | PERP, TP53 apoptosis effector | -0.0288181 |
| NDRG1 | N-myc downstream regulated 1 | -0.0282278 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0277121 |
| HDLBP | high density lipoprotein binding protein | -0.0276233 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0273938 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0272936 |
| MORF4L2 | mortality factor 4 like 2 | -0.0268212 |
| HM13 | histocompatibility (minor) 13 | -0.0268182 |
| RUNX1 | runt-related transcription factor 1 | -0.0267053 |
| EXOC4 | exocyst complex component 4 | -0.0266563 |
| ZNRF3 | zinc and ring finger 3 | -0.0265781 |
| PGK1 | phosphoglycerate kinase 1 | -0.0265497 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0265427 |
| SDC4 | syndecan 4 | -0.0263318 |
| NFIA | nuclear factor I/A | -0.0261961 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0261075 |
| FUS | FUS RNA binding protein | -0.0256392 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0253887 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0252809 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0251866 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0249484 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.024576 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0245011 |
| S100A10 | S100 calcium binding protein A10 | -0.0244559 |
| CTSD | cathepsin D | -0.0243304 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0241652 |
| IFITM2 | interferon induced transmembrane protein 2 | -0.0241522 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0239483 |
| CDK13 | cyclin-dependent kinase 13 | -0.0239305 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0237376 |
| HLA-E | major histocompatibility complex, class I, E | -0.0236935 |
| FRMD5 | FERM domain containing 5 | -0.0236113 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0235234 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0234543 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0233871 |
| CDK12 | cyclin-dependent kinase 12 | -0.0231647 |
| NOP58 | NOP58 ribonucleoprotein | -0.0231314 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0228828 |
| UBAP2 | ubiquitin associated protein 2 | -0.0223036 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0222224 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0222037 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0219244 |
| MYO1B | myosin IB | -0.0217654 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0216795 |
