| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in SW48 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0952273 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0936411 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0917204 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0834218 |
| ACTG1 | actin gamma 1 | 0.0808473 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0750365 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0736353 |
| RPS6 | ribosomal protein S6 | 0.0729854 |
| FERMT1 | fermitin family member 1 | 0.0693482 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0659772 |
| DSPP | dentin sialophosphoprotein | 0.0655983 |
| EZR | ezrin | 0.0637703 |
| LAMC2 | laminin, gamma 2 | 0.0583692 |
| LAMA4 | laminin, alpha 4 | 0.0549292 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.051865 |
| HMGA2 | high mobility group AT-hook 2 | 0.0514626 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.051425 |
| LAMB3 | laminin, beta 3 | 0.0495931 |
| NDRG1 | N-myc downstream regulated 1 | 0.0484707 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0481291 |
| GPC5 | glypican 5 | 0.0466233 |
| LMO7 | LIM domain 7 | 0.0461479 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0458743 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0448133 |
| EGR1 | early growth response 1 | 0.0418904 |
| RPL35A | ribosomal protein L35a | 0.0418738 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0404948 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0395743 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0389433 |
| NUP50 | nucleoporin 50kDa | 0.0382012 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.038148 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0376973 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0369245 |
| TPM4 | tropomyosin 4 | 0.0362279 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0354958 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0353092 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0353001 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0350189 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0341698 |
| YOD1 | YOD1 deubiquitinase | 0.0334457 |
| KLK10 | kallikrein-related peptidase 10 | 0.033288 |
| TSC22D2 | TSC22 domain family, member 2 | 0.032829 |
| IER3 | immediate early response 3 | 0.0314637 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0308752 |
| VEGFA | vascular endothelial growth factor A | 0.0305986 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0302937 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0299861 |
| S100A6 | S100 calcium binding protein A6 | 0.0298594 |
| SNX9 | sorting nexin 9 | 0.0298178 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0298083 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0296139 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0294705 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0285813 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0283319 |
| GOLGA4 | golgin A4 | 0.0282067 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.0281252 |
| EMP1 | epithelial membrane protein 1 | 0.0277582 |
| KRT18 | keratin 18, type I | 0.0276403 |
| PLAUR | plasminogen activator, urokinase receptor | 0.027213 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0271784 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0271292 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0261752 |
| ANXA1 | annexin A1 | 0.0254895 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0254733 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0254655 |
| FOXO1 | forkhead box O1 | 0.025408 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0253978 |
| ITPKC | inositol-trisphosphate 3-kinase C | 0.0253622 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0253282 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0235827 |
| TXNRD1 | thioredoxin reductase 1 | 0.0233467 |
| ARHGEF1 | Rho guanine nucleotide exchange factor (GEF) 1 | 0.0233072 |
| CDCP1 | CUB domain containing protein 1 | 0.0230772 |
| ABHD3 | abhydrolase domain containing 3 | 0.0228962 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0226913 |
| GDF15 | growth differentiation factor 15 | 0.0226553 |
| MYO5B | myosin VB | 0.0223643 |
| RPS14 | ribosomal protein S14 | 0.0221231 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0221097 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | 0.0217291 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0216739 |
| FOSL1 | FOS-like antigen 1 | 0.0213568 |
| OXSR1 | oxidative stress responsive 1 | 0.0212598 |
| PLEK2 | pleckstrin 2 | 0.021256 |
| ARFGEF3 | ARFGEF family member 3 | 0.0208112 |
| EGFR | epidermal growth factor receptor | 0.0207732 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.020692 |
| CUL5 | cullin 5 | 0.0203993 |
| BRD2 | bromodomain containing 2 | 0.0203183 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0201712 |
| FBXO11 | F-box protein 11 | 0.0200926 |
| MOSPD1 | motile sperm domain containing 1 | 0.0198159 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0197989 |
| KLK6 | kallikrein-related peptidase 6 | 0.0196293 |
| UBXN4 | UBX domain protein 4 | 0.0194502 |
| PRRC1 | proline-rich coiled-coil 1 | 0.0193762 |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.0193559 |
| NSRP1 | nuclear speckle splicing regulatory protein 1 | 0.0189915 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0188702 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0188696 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.19979 |
| RAD51B | RAD51 paralog B | -0.154628 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.117141 |
| FHIT | fragile histidine triad | -0.116505 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0970626 |
| TMSB10 | thymosin beta 10 | -0.093525 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.0916449 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.081869 |
| VCL | vinculin | -0.077383 |
| UBC | ubiquitin C | -0.0741947 |
| RPS27A | ribosomal protein S27a | -0.068835 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0659086 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0647513 |
| PTMA | prothymosin, alpha | -0.0623085 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0619601 |
| PCBP2 | poly(rC) binding protein 2 | -0.0613123 |
| GPHN | gephyrin | -0.0606659 |
| RPS24 | ribosomal protein S24 | -0.060596 |
| MTAP | methylthioadenosine phosphorylase | -0.057755 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.055951 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0546125 |
| PHF14 | PHD finger protein 14 | -0.0534651 |
| SFPQ | splicing factor proline/glutamine-rich | -0.052913 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0527706 |
| ATXN1 | ataxin 1 | -0.0512762 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0508792 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0493666 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.048028 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0461799 |
| RPL37A | ribosomal protein L37a | -0.0461656 |
| EXOC4 | exocyst complex component 4 | -0.046034 |
| AREG | amphiregulin | -0.0458226 |
| HDAC2 | histone deacetylase 2 | -0.0440485 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0439847 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0429867 |
| PRELID2 | PRELI domain containing 2 | -0.042922 |
| RBM25 | RNA binding motif protein 25 | -0.042539 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0422556 |
| DIAPH2 | diaphanous-related formin 2 | -0.0418626 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0417006 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0401841 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0400038 |
| RPS4X | ribosomal protein S4, X-linked | -0.0395726 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0380251 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0378156 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0371635 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0370775 |
| RPL23 | ribosomal protein L23 | -0.0368222 |
| OXR1 | oxidation resistance 1 | -0.0365142 |
| PKM | pyruvate kinase, muscle | -0.0362469 |
| ACTN4 | actinin, alpha 4 | -0.0361946 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0356387 |
| ADGRA3 | adhesion G protein-coupled receptor A3 | -0.0354396 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0342389 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0341643 |
| MSI2 | musashi RNA-binding protein 2 | -0.0337889 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0334098 |
| AHNAK | AHNAK nucleoprotein | -0.0332377 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0322906 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.031634 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0316018 |
| SMAD3 | SMAD family member 3 | -0.0309882 |
| RBM39 | RNA binding motif protein 39 | -0.0309268 |
| ENO1 | enolase 1, (alpha) | -0.0309163 |
| NFIA | nuclear factor I/A | -0.0308913 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0305785 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0304156 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0302899 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0301343 |
| ZBTB7C | zinc finger and BTB domain containing 7C | -0.0300865 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0298752 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0292552 |
| RPS3 | ribosomal protein S3 | -0.0291519 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0289349 |
| RPL36 | ribosomal protein L36 | -0.0288167 |
| DENND1A | DENN/MADD domain containing 1A | -0.0285806 |
| S100A10 | S100 calcium binding protein A10 | -0.0285599 |
| NAV2 | neuron navigator 2 | -0.0285334 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.0284428 |
| FRMD5 | FERM domain containing 5 | -0.0283218 |
| CEP152 | centrosomal protein 152kDa | -0.0282905 |
| ECT2 | epithelial cell transforming 2 | -0.0281688 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0281272 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0278884 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0276993 |
| RPL32 | ribosomal protein L32 | -0.0275042 |
| ZNRF3 | zinc and ring finger 3 | -0.0274788 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0268062 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0265305 |
| RPL9 | ribosomal protein L9 | -0.0262789 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0261847 |
| RPS29 | ribosomal protein S29 | -0.0259901 |
| NFIB | nuclear factor I/B | -0.0259245 |
| ANLN | anillin, actin binding protein | -0.0258391 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0257505 |
| TENM3 | teneurin transmembrane protein 3 | -0.0255735 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0254213 |
| CUX1 | cut-like homeobox 1 | -0.0253339 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0253185 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.025168 |
