| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in SW480 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.268365 |
| DSPP | dentin sialophosphoprotein | 0.077645 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0649952 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0559555 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0520675 |
| AOPEP | aminopeptidase O (putative) | 0.0517277 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0491155 |
| MATR3 | matrin 3 | 0.0472239 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.046223 |
| ENO1 | enolase 1, (alpha) | 0.0459251 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0458276 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0457947 |
| RPL26 | ribosomal protein L26 | 0.0443697 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0395599 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0393382 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0382607 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0362515 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0357792 |
| KRT18 | keratin 18, type I | 0.035379 |
| RPS3 | ribosomal protein S3 | 0.0346968 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0345352 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0343029 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0335307 |
| RASSF6 | Ras association (RalGDS/AF-6) domain family member 6 | 0.032691 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0307099 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0304653 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0299933 |
| PLEC | plectin | 0.0295012 |
| CANX | calnexin | 0.0294722 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0293832 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0286098 |
| RPS18 | ribosomal protein S18 | 0.0281447 |
| RPL4 | ribosomal protein L4 | 0.0271987 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0271589 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0270347 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.02664 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.026639 |
| SNX9 | sorting nexin 9 | 0.0263579 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0252448 |
| KIZ | kizuna centrosomal protein | 0.0249629 |
| LDHA | lactate dehydrogenase A | 0.0246947 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0246687 |
| JUN | jun proto-oncogene | 0.0242693 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0242299 |
| OGA | O-GlcNAcase | 0.0242263 |
| YBX1 | Y box binding protein 1 | 0.0239446 |
| TRAF5 | TNF receptor-associated factor 5 | 0.0238176 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0235118 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0231859 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0229496 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.0228326 |
| GOLGB1 | golgin B1 | 0.0224092 |
| MKI67 | marker of proliferation Ki-67 | 0.0224011 |
| VGLL4 | vestigial-like family member 4 | 0.0223429 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0219682 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0215864 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0215625 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0215263 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0210594 |
| PHF3 | PHD finger protein 3 | 0.020859 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0208262 |
| RPS2 | ribosomal protein S2 | 0.0207781 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0206939 |
| PPL | periplakin | 0.0206238 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0206144 |
| RPS7 | ribosomal protein S7 | 0.0204952 |
| TXNIP | thioredoxin interacting protein | 0.0203972 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0203671 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.020313 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0202393 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0201815 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0197094 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0196936 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0196886 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0196265 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0195606 |
| PGK1 | phosphoglycerate kinase 1 | 0.0192105 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0190454 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0190298 |
| RPL14 | ribosomal protein L14 | 0.0190104 |
| RLF | rearranged L-myc fusion | 0.0189166 |
| RPL3 | ribosomal protein L3 | 0.0188635 |
| TMF1 | TATA element modulatory factor 1 | 0.0186994 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0186906 |
| KARS1 | lysyl-tRNA synthetase 1 | 0.0182985 |
| GOLGA4 | golgin A4 | 0.0180081 |
| ABHD2 | abhydrolase domain containing 2 | 0.0180049 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0179627 |
| JMJD1C | jumonji domain containing 1C | 0.0177309 |
| LAMB3 | laminin, beta 3 | 0.0177044 |
| RACK1 | receptor for activated C kinase 1 | 0.0176431 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0176133 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0175487 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0174116 |
| AHNAK | AHNAK nucleoprotein | 0.0173083 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0172346 |
| TPR | translocated promoter region, nuclear basket protein | 0.0171892 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.0170646 |
| RAB1A | RAB1A, member RAS oncogene family | 0.017009 |
| H1-4 | H1.4 linker histone, cluster member | 0.0168505 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.146915 |
| NAV2 | neuron navigator 2 | -0.134157 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0970845 |
| INTS6 | integrator complex subunit 6 | -0.0965106 |
| VCL | vinculin | -0.0905072 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0877128 |
| CCND1 | cyclin D1 | -0.0859896 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0799249 |
| ACTG1 | actin gamma 1 | -0.0771787 |
| HMGA1 | high mobility group AT-hook 1 | -0.0753915 |
| PTMA | prothymosin, alpha | -0.0714648 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0664612 |
| PFN1 | profilin 1 | -0.066287 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0639177 |
| CDK6 | cyclin-dependent kinase 6 | -0.0628528 |
| ACTN4 | actinin, alpha 4 | -0.0621651 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0586518 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0580558 |
| CBX3 | chromobox homolog 3 | -0.0567888 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0552286 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0534379 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.049764 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0492647 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0465951 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.046527 |
| POTEF | POTE ankyrin domain family, member F | -0.0450324 |
| RPS19 | ribosomal protein S19 | -0.0449715 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0423904 |
| FLNB | filamin B, beta | -0.042346 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0419737 |
| RCOR1 | REST corepressor 1 | -0.0417991 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.041309 |
| NSMF | NMDA receptor synaptonuclear signaling and neuronal migration factor | -0.04122 |
| ASPH | aspartate beta-hydroxylase | -0.0409792 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0404359 |
| UBAP2 | ubiquitin associated protein 2 | -0.0403392 |
| ACTN1 | actinin, alpha 1 | -0.0397973 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0389164 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0378853 |
| RPS21 | ribosomal protein S21 | -0.0378754 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0376793 |
| PCBP2 | poly(rC) binding protein 2 | -0.0373914 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0369535 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0365978 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 | -0.0365767 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0360689 |
| RPL23 | ribosomal protein L23 | -0.0360301 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0354937 |
| HMGB1 | high mobility group box 1 | -0.035446 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.033907 |
| PKM | pyruvate kinase, muscle | -0.0338508 |
| CBX5 | chromobox homolog 5 | -0.0335539 |
| VIM | vimentin | -0.0330257 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0328523 |
| PHF14 | PHD finger protein 14 | -0.0324201 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0323412 |
| TMEM123 | transmembrane protein 123 | -0.0322315 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.032213 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0322065 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0320317 |
| ITGB4 | integrin, beta 4 | -0.0313792 |
| MED13 | mediator complex subunit 13 | -0.030967 |
| RAD51B | RAD51 paralog B | -0.0302301 |
| DST | dystonin | -0.0301925 |
| EXOC4 | exocyst complex component 4 | -0.0300687 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0298566 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.029438 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0293482 |
| RPLP2 | ribosomal protein, large, P2 | -0.0290938 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0290375 |
| RPL28 | ribosomal protein L28 | -0.0286452 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0282493 |
| EGR1 | early growth response 1 | -0.0281772 |
| RPS23 | ribosomal protein S23 | -0.0277681 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0277637 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0276746 |
| LAMA4 | laminin, alpha 4 | -0.027532 |
| CUX1 | cut-like homeobox 1 | -0.0274246 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0271261 |
| ASTN2 | astrotactin 2 | -0.0269672 |
| GATAD2A | GATA zinc finger domain containing 2A | -0.0268155 |
| RPS6 | ribosomal protein S6 | -0.0267934 |
| GNAS | GNAS complex locus | -0.0267125 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0266462 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0266454 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0266415 |
| TUBA1B | tubulin, alpha 1b | -0.0265989 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0265684 |
| RPS14 | ribosomal protein S14 | -0.0265272 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0263913 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.0262696 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0262479 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0258014 |
| RPL18 | ribosomal protein L18 | -0.0257566 |
| SRPK2 | SRSF protein kinase 2 | -0.0255269 |
| IPO7 | importin 7 | -0.0255008 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0253639 |
| ERBIN | erbb2 interacting protein | -0.0251514 |
| RBP1 | retinol binding protein 1, cellular | -0.0244892 |
| RPL32 | ribosomal protein L32 | -0.0243139 |
