| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib (citrate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib (citrate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.285505 |
| FN1 | fibronectin 1 | 0.213873 |
| CD44 | CD44 molecule (Indian blood group) | 0.187577 |
| MYO10 | myosin X | 0.143203 |
| B2M | beta-2-microglobulin | 0.0876942 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0876303 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.084741 |
| STC1 | stanniocalcin 1 | 0.0760138 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0584324 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0552354 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0512615 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.050257 |
| ATP13A3 | ATPase type 13A3 | 0.046315 |
| VEGFA | vascular endothelial growth factor A | 0.0448676 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0388606 |
| MT2A | metallothionein 2A | 0.0368514 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0364332 |
| LOXL2 | lysyl oxidase-like 2 | 0.0355309 |
| FRMD6 | FERM domain containing 6 | 0.0352544 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.03468 |
| CLMP | CXADR-like membrane protein | 0.0316104 |
| NDRG1 | N-myc downstream regulated 1 | 0.0309864 |
| TPM3 | tropomyosin 3 | 0.0307906 |
| NOTCH2 | notch 2 | 0.0307865 |
| ANXA2 | annexin A2 | 0.0305227 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0304406 |
| RPS3 | ribosomal protein S3 | 0.029677 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0291889 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0291791 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0291704 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0291654 |
| EGFR | epidermal growth factor receptor | 0.028842 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.028099 |
| MMP12 | matrix metallopeptidase 12 | 0.0273175 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0267548 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0253358 |
| DSPP | dentin sialophosphoprotein | 0.0252611 |
| RPS17 | ribosomal protein S17 | 0.0241354 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0231662 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0230782 |
| RACK1 | receptor for activated C kinase 1 | 0.0229027 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0228318 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0225611 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0224448 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0219061 |
| RPS12 | ribosomal protein S12 | 0.0218789 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0218144 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0218143 |
| SMAD3 | SMAD family member 3 | 0.0218064 |
| RPS7 | ribosomal protein S7 | 0.0216975 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.0215718 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0215026 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0214672 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0213534 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0207553 |
| MAP1B | microtubule-associated protein 1B | 0.0207535 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0206131 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0203313 |
| RNF145 | ring finger protein 145 | 0.0202736 |
| MSN | moesin | 0.0202523 |
| TNS1 | tensin 1 | 0.0198534 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.019724 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0196661 |
| ETV3 | ets variant 3 | 0.0194879 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.019433 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0193825 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0192736 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0192405 |
| HMGA2 | high mobility group AT-hook 2 | 0.0189368 |
| RPL37 | ribosomal protein L37 | 0.0188844 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0184852 |
| SET | SET nuclear proto-oncogene | 0.0184095 |
| RPL12 | ribosomal protein L12 | 0.0182213 |
| PGK1 | phosphoglycerate kinase 1 | 0.01819 |
| RASA3 | RAS p21 protein activator 3 | 0.0180876 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0179814 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0179144 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0177027 |
| ANGPTL4 | angiopoietin-like 4 | 0.0174979 |
| TXNIP | thioredoxin interacting protein | 0.017443 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.017431 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0170476 |
| CDK17 | cyclin-dependent kinase 17 | 0.0170072 |
| ENO1 | enolase 1, (alpha) | 0.0169676 |
| RPS18 | ribosomal protein S18 | 0.0167814 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0167734 |
| FAM13A | family with sequence similarity 13, member A | 0.0167582 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0167507 |
| TMEM165 | transmembrane protein 165 | 0.016664 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0164199 |
| TMF1 | TATA element modulatory factor 1 | 0.0162916 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0160077 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0159181 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0158169 |
| ARRDC3 | arrestin domain containing 3 | 0.0156029 |
| NKTR | natural killer cell triggering receptor | 0.0155632 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0155627 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0155604 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0154893 |
| DUSP6 | dual specificity phosphatase 6 | 0.015412 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.212843 |
| VIM | vimentin | -0.153862 |
| COL6A3 | collagen, type VI, alpha 3 | -0.12949 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.125792 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.118034 |
| COL1A2 | collagen, type I, alpha 2 | -0.106037 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0779684 |
| TMSB10 | thymosin beta 10 | -0.0677581 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.065614 |
| COL3A1 | collagen, type III, alpha 1 | -0.0628222 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0613726 |
| COL5A2 | collagen, type V, alpha 2 | -0.0576073 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0572355 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.051467 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0512564 |
| CDH13 | cadherin 13 | -0.047241 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0458703 |
| OXR1 | oxidation resistance 1 | -0.0456058 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0450335 |
| INTS6 | integrator complex subunit 6 | -0.0433988 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0433249 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0432848 |
| S100A6 | S100 calcium binding protein A6 | -0.0405325 |
| CALD1 | caldesmon 1 | -0.0400729 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0393411 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0387525 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0378049 |
| TPM4 | tropomyosin 4 | -0.037701 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0364221 |
| PRSS23 | protease, serine, 23 | -0.0361769 |
| CAVIN1 | caveolae associated protein 1 | -0.0360555 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0355664 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0349135 |
| PTMA | prothymosin, alpha | -0.0347975 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0346723 |
| DNER | delta/notch-like EGF repeat containing | -0.0333086 |
| FBN1 | fibrillin 1 | -0.0331303 |
| ACTG1 | actin gamma 1 | -0.0329721 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0327534 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0327436 |
| NAV1 | neuron navigator 1 | -0.0320623 |
| AHNAK | AHNAK nucleoprotein | -0.0316622 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0314619 |
| VCL | vinculin | -0.0310106 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0305254 |
| PRR16 | proline rich 16 | -0.0304575 |
| IGF2 | insulin-like growth factor 2 | -0.030367 |
| COL4A1 | collagen, type IV, alpha 1 | -0.030003 |
| PKM | pyruvate kinase, muscle | -0.0299459 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0298094 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0296501 |
| RPLP1 | ribosomal protein, large, P1 | -0.0284258 |
| HDLBP | high density lipoprotein binding protein | -0.0282341 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0280973 |
| RNF213 | ring finger protein 213 | -0.0279384 |
| RPL34 | ribosomal protein L34 | -0.0271527 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0267669 |
| OSMR | oncostatin M receptor | -0.0262404 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.026233 |
| MMP1 | matrix metallopeptidase 1 | -0.0261932 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0260147 |
| COL5A1 | collagen, type V, alpha 1 | -0.0256257 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.025543 |
| NREP | neuronal regeneration related protein | -0.0247823 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | -0.0247417 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0246346 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0244633 |
| COG6 | component of oligomeric golgi complex 6 | -0.0244094 |
| MTSS1 | metastasis suppressor 1 | -0.0243217 |
| GNAS | GNAS complex locus | -0.0242666 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0239063 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.023407 |
| SPAG9 | sperm associated antigen 9 | -0.0233629 |
| PCDH7 | protocadherin 7 | -0.0231059 |
| AEBP2 | AE binding protein 2 | -0.0231027 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0229675 |
| SNX14 | sorting nexin 14 | -0.0227271 |
| IER3 | immediate early response 3 | -0.0226362 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0226055 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0225628 |
| CCDC102B | coiled-coil domain containing 102B | -0.0225047 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0222975 |
| FTL | ferritin, light polypeptide | -0.0222628 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0219275 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0217114 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0216734 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0216554 |
| CUX1 | cut-like homeobox 1 | -0.0216311 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0215111 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0207598 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0207066 |
| RRBP1 | ribosome binding protein 1 | -0.0206703 |
| RPS16 | ribosomal protein S16 | -0.020667 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.020647 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0205951 |
| GLG1 | golgi glycoprotein 1 | -0.0205583 |
| RUNX1 | runt-related transcription factor 1 | -0.0203569 |
| SERF2 | small EDRK-rich factor 2 | -0.020328 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0202509 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0199919 |
