| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/9926791 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Tofacitinib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CBLL1 | Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase | 0.56 |
| MPZL2 | myelin protein zero-like 2 | 0.5 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.43 |
| MIEN1 | migration and invasion enhancer 1 | 0.42 |
| CBY1 | chibby homolog 1 (Drosophila) | 0.4 |
| H3C1 | H3 clustered histone 1 | 0.4 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.39 |
| CNTNAP3 | contactin associated protein-like 3 | 0.39 |
| ADSS1 | adenylosuccinate synthase 1 | 0.37 |
| FN3K | fructosamine 3 kinase | 0.37 |
| ATP5F1D | ATP synthase F1 subunit delta | 0.36 |
| WDR20 | WD repeat domain 20 | 0.34 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 0.34 |
| PIAS3 | protein inhibitor of activated STAT, 3 | 0.33 |
| METAP1D | methionyl aminopeptidase type 1D (mitochondrial) | 0.33 |
| CDC25B | cell division cycle 25B | 0.33 |
| PRR5 | proline rich 5 (renal) | 0.33 |
| MRNIP | MRN complex interacting protein | 0.33 |
| ZNF142 | zinc finger protein 142 | 0.33 |
| ZNF440 | zinc finger protein 440 | 0.33 |
| CARD19 | caspase recruitment domain family member 19 | 0.32 |
| PSRC1 | proline/serine-rich coiled-coil 1 | 0.32 |
| TASP1 | taspase, threonine aspartase, 1 | 0.32 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | 0.31 |
| TRAIP | TRAF interacting protein | 0.31 |
| MSX1 | msh homeobox 1 | 0.31 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | 0.31 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.31 |
| ACAP3 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 | 0.31 |
| MAST3 | microtubule associated serine/threonine kinase 3 | 0.3 |
| CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa | 0.3 |
| RAD9A | RAD9 homolog A (S. pombe) | 0.3 |
| CTTNBP2 | cortactin binding protein 2 | 0.3 |
| C5ORF51 | chromosome 5 open reading frame 51 | 0.29 |
| RANBP17 | RAN binding protein 17 | 0.29 |
| LMOD1 | leiomodin 1 (smooth muscle) | 0.29 |
| ATF7 | activating transcription factor 7 | 0.29 |
| CYP4F22 | cytochrome P450, family 4, subfamily F, polypeptide 22 | 0.29 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 0.29 |
| XTBD1 | XRN2 binding domain containing 1 | 0.28 |
| POP5 | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) | 0.28 |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | 0.28 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.28 |
| NKIRAS2 | NFKB inhibitor interacting Ras-like 2 | 0.28 |
| UBL5 | ubiquitin-like 5 | 0.28 |
| KYAT1 | kynurenine aminotransferase 1 | 0.28 |
| HTT | huntingtin | 0.28 |
| LYPLA2 | lysophospholipase II | 0.27 |
| ERH | enhancer of rudimentary homolog (Drosophila) | 0.27 |
| DET1 | de-etiolated homolog 1 (Arabidopsis) | 0.27 |
| ZNF236 | zinc finger protein 236 | 0.26 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.26 |
| PET117 | PET117 homolog (S. cerevisiae) | 0.26 |
| DUSP6 | dual specificity phosphatase 6 | 0.26 |
| FAM136A | family with sequence similarity 136, member A | 0.26 |
| NME6 | NME/NM23 nucleoside diphosphate kinase 6 | 0.26 |
| ZNF552 | zinc finger protein 552 | 0.26 |
| TTC8 | tetratricopeptide repeat domain 8 | 0.26 |
| TXNL4B | thioredoxin-like 4B | 0.25 |
| POMP | proteasome maturation protein | 0.25 |
| XDH | xanthine dehydrogenase | 0.25 |
| COPZ1 | coatomer protein complex, subunit zeta 1 | 0.25 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.25 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.25 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | 0.24 |
| EHF | ets homologous factor | 0.24 |
| AADAT | aminoadipate aminotransferase | 0.24 |
| C15ORF40 | chromosome 15 open reading frame 40 | 0.24 |
| SF1 | splicing factor 1 | 0.24 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.24 |
| SRI | sorcin | 0.24 |
| PCDH1 | protocadherin 1 | 0.24 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | 0.24 |
| NUDT1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | 0.24 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.23 |
| MON1A | MON1 secretory trafficking family member A | 0.23 |
| CLUH | clustered mitochondria (cluA/CLU1) homolog | 0.23 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.23 |
| NEBL | nebulette | 0.23 |
| VWDE | von Willebrand factor D and EGF domains | 0.23 |
| SIK2 | salt-inducible kinase 2 | 0.23 |
| PIP4P2 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | 0.23 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | 0.23 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.23 |
| ZMAT5 | zinc finger, matrin-type 5 | 0.23 |
| MTPN | myotrophin | 0.23 |
| GSTO2 | glutathione S-transferase omega 2 | 0.23 |
| C1ORF43 | chromosome 1 open reading frame 43 | 0.23 |
| DENND5B | DENN/MADD domain containing 5B | 0.23 |
| SERF2 | small EDRK-rich factor 2 | 0.22 |
| SMIM12 | small integral membrane protein 12 | 0.22 |
| LARGE2 | LARGE xylosyl- and glucuronyltransferase 2 | 0.22 |
| DYNLL2 | dynein, light chain, LC8-type 2 | 0.22 |
| COPE | coatomer protein complex, subunit epsilon | 0.22 |
| TNRC18 | trinucleotide repeat containing 18 | 0.22 |
| BCAS2 | breast carcinoma amplified sequence 2 | 0.22 |
| ZNF587 | zinc finger protein 587 | 0.22 |
| RNH1 | ribonuclease/angiogenin inhibitor 1 | 0.22 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.22 |
| ADIRF | adipogenesis regulatory factor | 0.21 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SBSN | suprabasin | -1.06 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.82 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | -0.71 |
| B3GALNT2 | beta-1,3-N-acetylgalactosaminyltransferase 2 | -0.7 |
| PIGQ | phosphatidylinositol glycan anchor biosynthesis, class Q | -0.69 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | -0.53 |
| SKIL | SKI-like proto-oncogene | -0.52 |
| STC2 | stanniocalcin 2 | -0.51 |
| FBXO44 | F-box protein 44 | -0.5 |
| ECM1 | extracellular matrix protein 1 | -0.49 |
| GK | glycerol kinase | -0.47 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.47 |
| SERINC1 | serine incorporator 1 | -0.46 |
| PIP | prolactin-induced protein | -0.46 |
| B4GAT1 | beta-1,4-glucuronyltransferase 1 | -0.45 |
| ZNF724 | zinc finger protein 724 | -0.43 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.43 |
| PLEKHA3 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 | -0.42 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | -0.42 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.41 |
| H1-0 | H1.0 linker histone | -0.41 |
| KAT14 | lysine acetyltransferase 14 | -0.4 |
| ZNF616 | zinc finger protein 616 | -0.4 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | -0.39 |
| FBRSL1 | fibrosin-like 1 | -0.39 |
| RIC1 | RAB6A GEF complex partner 1 | -0.39 |
| ZNF691 | zinc finger protein 691 | -0.38 |
| JUN | jun proto-oncogene | -0.38 |
| ICAM5 | intercellular adhesion molecule 5, telencephalin | -0.38 |
| CD63 | CD63 molecule | -0.37 |
| SH3RF2 | SH3 domain containing ring finger 2 | -0.37 |
| CPA4 | carboxypeptidase A4 | -0.37 |
| SLC45A1 | solute carrier family 45, member 1 | -0.37 |
| TAPT1 | transmembrane anterior posterior transformation 1 | -0.37 |
| ARL13B | ADP-ribosylation factor-like 13B | -0.36 |
| TULP3 | tubby like protein 3 | -0.36 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.35 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | -0.35 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.34 |
| TXNDC11 | thioredoxin domain containing 11 | -0.34 |
| ZSWIM8 | zinc finger, SWIM-type containing 8 | -0.34 |
| NES | nestin | -0.33 |
| CERCAM | cerebral endothelial cell adhesion molecule | -0.33 |
| ACSL6 | acyl-CoA synthetase long-chain family member 6 | -0.32 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.31 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.31 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.3 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.3 |
| MYH6 | myosin, heavy chain 6, cardiac muscle, alpha | -0.3 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.3 |
| EPS8L1 | EPS8-like 1 | -0.3 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.3 |
| WTAP | Wilms tumor 1 associated protein | -0.29 |
| CCDC88A | coiled-coil domain containing 88A | -0.29 |
| TPM1 | tropomyosin 1 (alpha) | -0.28 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.28 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | -0.28 |
| APOE | apolipoprotein E | -0.28 |
| GDE1 | glycerophosphodiester phosphodiesterase 1 | -0.28 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | -0.27 |
| LAMB3 | laminin, beta 3 | -0.27 |
| PRRG1 | proline rich Gla (G-carboxyglutamic acid) 1 | -0.27 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -0.27 |
| TIGD5 | tigger transposable element derived 5 | -0.27 |
| TMEM263 | transmembrane protein 263 | -0.27 |
| FGFR1OP2 | FGFR1 oncogene partner 2 | -0.27 |
| PAFAH2 | platelet-activating factor acetylhydrolase 2, 40kDa | -0.27 |
| ATP11B | ATPase, class VI, type 11B | -0.27 |
| NAV3 | neuron navigator 3 | -0.27 |
| NDUFA11 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa | -0.27 |
| HEXIM2 | hexamethylene bis-acetamide inducible 2 | -0.27 |
| TMC6 | transmembrane channel-like 6 | -0.26 |
| BRD9 | bromodomain containing 9 | -0.26 |
| TMEM39A | transmembrane protein 39A | -0.26 |
| UPP1 | uridine phosphorylase 1 | -0.26 |
| ZNF200 | zinc finger protein 200 | -0.26 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.26 |
| CDC34 | cell division cycle 34 | -0.25 |
| LAMP2 | lysosomal-associated membrane protein 2 | -0.25 |
| PHLDB3 | pleckstrin homology-like domain, family B, member 3 | -0.25 |
| FN1 | fibronectin 1 | -0.25 |
| SC5D | sterol-C5-desaturase | -0.25 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -0.25 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.25 |
| ZDHHC18 | zinc finger, DHHC-type containing 18 | -0.25 |
| FLNA | filamin A, alpha | -0.25 |
| HDAC4 | histone deacetylase 4 | -0.25 |
| CNTROB | centrobin, centrosomal BRCA2 interacting protein | -0.24 |
| FLNB | filamin B, beta | -0.24 |
| PPP1R35 | protein phosphatase 1, regulatory subunit 35 | -0.24 |
| SLC38A1 | solute carrier family 38, member 1 | -0.24 |
| PLEKHF1 | pleckstrin homology domain containing, family F (with FYVE domain) member 1 | -0.24 |
| MCF2L | MCF.2 cell line derived transforming sequence-like | -0.24 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.24 |
| CCNE1 | cyclin E1 | -0.24 |
| PAQR7 | progestin and adipoQ receptor family member VII | -0.24 |
| MTERF1 | mitochondrial transcription termination factor 1 | -0.24 |
| FOSL1 | FOS-like antigen 1 | -0.24 |
