| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.246904 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.102532 |
| UBC | ubiquitin C | 0.0961141 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0787969 |
| GLIS3 | GLIS family zinc finger 3 | 0.0783146 |
| SQSTM1 | sequestosome 1 | 0.0658407 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0640426 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0594899 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0585456 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0579887 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.056542 |
| LOX | lysyl oxidase | 0.0550192 |
| B2M | beta-2-microglobulin | 0.0497441 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0494206 |
| VCL | vinculin | 0.0445634 |
| FTL | ferritin, light polypeptide | 0.0439378 |
| CDH13 | cadherin 13 | 0.0431653 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0400536 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0397767 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0397713 |
| VEGFC | vascular endothelial growth factor C | 0.039392 |
| STC1 | stanniocalcin 1 | 0.0377258 |
| MB21D2 | Mab-21 domain containing 2 | 0.0366194 |
| FBXO11 | F-box protein 11 | 0.0362733 |
| INTS6 | integrator complex subunit 6 | 0.0360525 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0360427 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0355917 |
| UBAP2 | ubiquitin associated protein 2 | 0.0328477 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0327724 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0322518 |
| HLA-B | major histocompatibility complex, class I, B | 0.0321429 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0305889 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0304508 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0302803 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0298074 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0297729 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0292995 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0291696 |
| UBAP1 | ubiquitin associated protein 1 | 0.0289452 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0289322 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0288092 |
| LDHA | lactate dehydrogenase A | 0.0286543 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0284717 |
| ANO6 | anoctamin 6 | 0.0284338 |
| TAOK1 | TAO kinase 1 | 0.0282643 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0280092 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.027804 |
| ADM | adrenomedullin | 0.0276096 |
| ZNF207 | zinc finger protein 207 | 0.0275164 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0274496 |
| FNBP1L | formin binding protein 1-like | 0.0268885 |
| RHEB | Ras homolog enriched in brain | 0.0268026 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0266493 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0258927 |
| FMNL2 | formin-like 2 | 0.0257374 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0256016 |
| EFNA5 | ephrin-A5 | 0.0255582 |
| FAM107B | family with sequence similarity 107, member B | 0.0254286 |
| COPA | coatomer protein complex, subunit alpha | 0.0253723 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0253502 |
| RPL28 | ribosomal protein L28 | 0.0248089 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0247704 |
| MORF4L2 | mortality factor 4 like 2 | 0.0246465 |
| MAP1B | microtubule-associated protein 1B | 0.0245633 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0243129 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0242337 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0241997 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | 0.0241548 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0241523 |
| USP12 | ubiquitin specific peptidase 12 | 0.0236639 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0236162 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0234376 |
| GOLGB1 | golgin B1 | 0.0231191 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.023115 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0231139 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0230089 |
| CALU | calumenin | 0.0228735 |
| CD99 | CD99 molecule | 0.0228709 |
| RAB2A | RAB2A, member RAS oncogene family | 0.022769 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0226243 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0224551 |
| UBTD2 | ubiquitin domain containing 2 | 0.0223788 |
| RNF169 | ring finger protein 169 | 0.0223447 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0223431 |
| PKM | pyruvate kinase, muscle | 0.0222927 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0222633 |
| CSTB | cystatin B (stefin B) | 0.0221001 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0219652 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0219357 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0217861 |
| RPS23 | ribosomal protein S23 | 0.0216235 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0214959 |
| RTN3 | reticulon 3 | 0.021432 |
| JMJD1C | jumonji domain containing 1C | 0.0211996 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0210776 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.0209514 |
| RFTN1 | raftlin, lipid raft linker 1 | 0.0209006 |
| TFG | TRK-fused gene | 0.020868 |
| CCNY | cyclin Y | 0.0208384 |
| DLGAP3 | discs, large (Drosophila) homolog-associated protein 3 | 0.0205738 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.216872 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.175442 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.133024 |
| COL5A1 | collagen, type V, alpha 1 | -0.12323 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.121169 |
| PODXL | podocalyxin-like | -0.0902444 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0901904 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.084933 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0833693 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.082853 |
| FN1 | fibronectin 1 | -0.0787316 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0787296 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0775402 |
| MX2 | MX dynamin-like GTPase 2 | -0.0759491 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0742683 |
| RIGI | RNA sensor RIG-I | -0.0720476 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0611201 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0608427 |
| FLNB | filamin B, beta | -0.0580826 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0566962 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0554602 |
| RNF213 | ring finger protein 213 | -0.0541404 |
| MEIS2 | Meis homeobox 2 | -0.0534285 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0511038 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0505431 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0499587 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0497783 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.049767 |
| CUX1 | cut-like homeobox 1 | -0.0474701 |
| TMSB10 | thymosin beta 10 | -0.0463593 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0443288 |
| FLNA | filamin A, alpha | -0.0426123 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0421223 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0403244 |
| DCLK2 | doublecortin-like kinase 2 | -0.0400188 |
| LOXL2 | lysyl oxidase-like 2 | -0.0392761 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.03823 |
| PFKP | phosphofructokinase, platelet | -0.0378885 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0374825 |
| NAV2 | neuron navigator 2 | -0.0373679 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0365312 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0364402 |
| NDRG1 | N-myc downstream regulated 1 | -0.0361686 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0355858 |
| ADAR | adenosine deaminase, RNA-specific | -0.0345816 |
| XRN1 | 5'-3' exoribonuclease 1 | -0.0343149 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0340016 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0338102 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0337455 |
| MYADM | myeloid-associated differentiation marker | -0.0336582 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0335726 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0335658 |
| TMSB4X | thymosin beta 4, X-linked | -0.0325372 |
| FNDC3A | fibronectin type III domain containing 3A | -0.032153 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0316736 |
| MSI2 | musashi RNA-binding protein 2 | -0.0310261 |
| PRELID2 | PRELI domain containing 2 | -0.0309949 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0308303 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0307445 |
| TAGLN2 | transgelin 2 | -0.0300899 |
| TRAM2 | translocation associated membrane protein 2 | -0.0300678 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0298958 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0293449 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.0288944 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0287969 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0287612 |
| TNS3 | tensin 3 | -0.0285493 |
| OSMR | oncostatin M receptor | -0.0284091 |
| TDRD7 | tudor domain containing 7 | -0.0279825 |
| MT1X | metallothionein 1X | -0.0275845 |
| CD109 | CD109 molecule | -0.0275422 |
| PLSCR1 | phospholipid scramblase 1 | -0.0273977 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0271081 |
| RAI1 | retinoic acid induced 1 | -0.0270318 |
| TOX | thymocyte selection-associated high mobility group box | -0.0270212 |
| PRSS23 | protease, serine, 23 | -0.0269448 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0268261 |
| CBX3 | chromobox homolog 3 | -0.0267691 |
| SRPK2 | SRSF protein kinase 2 | -0.0267246 |
| TUBB6 | tubulin, beta 6 class V | -0.0259125 |
| IFI44L | interferon-induced protein 44-like | -0.0257072 |
| GIGYF2 | GRB10 interacting GYF protein 2 | -0.0256895 |
| EGFR | epidermal growth factor receptor | -0.0255018 |
| PLCB4 | phospholipase C, beta 4 | -0.0247998 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0247968 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.024794 |
| TPI1 | triosephosphate isomerase 1 | -0.0246362 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0245936 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0243334 |
| TBC1D9B | TBC1 domain family, member 9B (with GRAM domain) | -0.0241447 |
| NF1 | neurofibromin 1 | -0.0241267 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0238399 |
| PGK1 | phosphoglycerate kinase 1 | -0.023701 |
| INVS | inversin | -0.0227445 |
| FGF13 | fibroblast growth factor 13 | -0.0225521 |
| OR51B5 | olfactory receptor, family 51, subfamily B, member 5 | -0.0221686 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0221207 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0221078 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0219319 |
| AUTS2 | autism susceptibility candidate 2 | -0.0219249 |
