| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.146096 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.133585 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.120574 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0877307 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0838132 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0779666 |
| PCBP2 | poly(rC) binding protein 2 | 0.0683025 |
| MGAT4C | MGAT4 family, member C | 0.0588118 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0565912 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.05649 |
| CPOX | coproporphyrinogen oxidase | 0.055827 |
| HMGA1 | high mobility group AT-hook 1 | 0.0534785 |
| PCM1 | pericentriolar material 1 | 0.052412 |
| HMGA2 | high mobility group AT-hook 2 | 0.0518944 |
| NEBL | nebulette | 0.0496024 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0487527 |
| PDGFC | platelet derived growth factor C | 0.0481563 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0477652 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0469202 |
| ECT2 | epithelial cell transforming 2 | 0.0466211 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0465133 |
| SETD5 | SET domain containing 5 | 0.0464189 |
| FSTL5 | follistatin-like 5 | 0.0463002 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0456999 |
| XPO1 | exportin 1 | 0.0447163 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0422787 |
| WWOX | WW domain containing oxidoreductase | 0.0422206 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0411604 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0409524 |
| MED13L | mediator complex subunit 13-like | 0.0387814 |
| TENM3 | teneurin transmembrane protein 3 | 0.0381171 |
| ZNF638 | zinc finger protein 638 | 0.0372141 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0371173 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0370535 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0369693 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0369513 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0366435 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0361919 |
| ATP11B | ATPase, class VI, type 11B | 0.0361041 |
| CEP192 | centrosomal protein 192kDa | 0.0359978 |
| YAP1 | Yes-associated protein 1 | 0.0359909 |
| PNN | pinin, desmosome associated protein | 0.0352583 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0350497 |
| AUTS2 | autism susceptibility candidate 2 | 0.034682 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0346556 |
| NEK7 | NIMA-related kinase 7 | 0.0343424 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0340381 |
| ETNK1 | ethanolamine kinase 1 | 0.0335643 |
| NDC80 | NDC80 kinetochore complex component | 0.033386 |
| TBK1 | TANK-binding kinase 1 | 0.033244 |
| MMP12 | matrix metallopeptidase 12 | 0.0328727 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0327087 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0317976 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0313825 |
| PRELID2 | PRELI domain containing 2 | 0.0306107 |
| VCL | vinculin | 0.0304865 |
| ATP13A3 | ATPase type 13A3 | 0.0289615 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | 0.0289402 |
| CCDC88A | coiled-coil domain containing 88A | 0.0288882 |
| TXNRD1 | thioredoxin reductase 1 | 0.028814 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0287077 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | 0.0281163 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0280834 |
| FOXM1 | forkhead box M1 | 0.0280771 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0280732 |
| USP24 | ubiquitin specific peptidase 24 | 0.0280366 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0272666 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0271513 |
| ASPH | aspartate beta-hydroxylase | 0.0268704 |
| MYO6 | myosin VI | 0.0264622 |
| JMJD1C | jumonji domain containing 1C | 0.026461 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0263919 |
| TFG | TRK-fused gene | 0.0260915 |
| MPG | N-methylpurine-DNA glycosylase | 0.0258269 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0257747 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0257712 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0254674 |
| BBX | bobby sox homolog (Drosophila) | 0.0254577 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.025455 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.025325 |
| HOMER1 | homer scaffolding protein 1 | 0.0251947 |
| CPNE1 | copine I | 0.0251414 |
| MORF4L2 | mortality factor 4 like 2 | 0.0251164 |
| ATG10 | autophagy related 10 | 0.0248984 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0248337 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0248106 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0247737 |
| SPAG9 | sperm associated antigen 9 | 0.0247451 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0246142 |
| STAG2 | stromal antigen 2 | 0.0245915 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | 0.0244604 |
| GOLGA4 | golgin A4 | 0.0241921 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.0241545 |
| PFN1 | profilin 1 | 0.0240645 |
| RTN4 | reticulon 4 | 0.02395 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0238063 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0237113 |
| ZNF148 | zinc finger protein 148 | 0.0236764 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0235582 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.023437 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.341636 |
| VIM | vimentin | -0.242981 |
| ACTG1 | actin gamma 1 | -0.112346 |
| TMSB10 | thymosin beta 10 | -0.0990035 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0815374 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0713571 |
| AHNAK | AHNAK nucleoprotein | -0.0712718 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0692602 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.066572 |
| RASAL2 | RAS protein activator like 2 | -0.0664872 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.065816 |
| DST | dystonin | -0.0630475 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0616566 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0535425 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0448111 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0439125 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0438484 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0431536 |
| ANXA1 | annexin A1 | -0.0405574 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0395313 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0394608 |
| CMIP | c-Maf inducing protein | -0.0392445 |
| BCHE | butyrylcholinesterase | -0.0391537 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.039144 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0389745 |
| AK1 | adenylate kinase 1 | -0.0382935 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0381775 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0378055 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0373977 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0354783 |
| YBX3 | Y box binding protein 3 | -0.0354153 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0353348 |
| GPHN | gephyrin | -0.0352472 |
| TBCA | tubulin folding cofactor A | -0.0349297 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0344111 |
| EGR1 | early growth response 1 | -0.0336492 |
| FUS | FUS RNA binding protein | -0.0333416 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0331244 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.032832 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0326812 |
| RPL26 | ribosomal protein L26 | -0.032132 |
| CUX1 | cut-like homeobox 1 | -0.0318994 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0309765 |
| EHBP1 | EH domain binding protein 1 | -0.0308879 |
| RPL19 | ribosomal protein L19 | -0.030322 |
| RPS14 | ribosomal protein S14 | -0.0298874 |
| CLDN1 | claudin 1 | -0.0297115 |
| TEAD4 | TEA domain family member 4 | -0.0296672 |
| RPS27A | ribosomal protein S27a | -0.0295696 |
| OSMR | oncostatin M receptor | -0.0294753 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0290293 |
| RNF213 | ring finger protein 213 | -0.0289934 |
| RPL37 | ribosomal protein L37 | -0.0289491 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0279786 |
| RPS12 | ribosomal protein S12 | -0.0278196 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0277935 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0277926 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0277341 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0275282 |
| ZNF804A | zinc finger protein 804A | -0.0272397 |
| RPL35A | ribosomal protein L35a | -0.0268112 |
| SQSTM1 | sequestosome 1 | -0.0264229 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0261423 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0254364 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0251599 |
| PCDH7 | protocadherin 7 | -0.0250095 |
| TMEM108 | transmembrane protein 108 | -0.0245687 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0245168 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0244496 |
| RPL36A | ribosomal protein L36a | -0.0242216 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0241314 |
| RPL4 | ribosomal protein L4 | -0.0241057 |
| RBM19 | RNA binding motif protein 19 | -0.0238496 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0238417 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0236535 |
| RPL27A | ribosomal protein L27a | -0.0234997 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0234563 |
| THADA | thyroid adenoma associated | -0.0233783 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.023283 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0231335 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.023006 |
| SYT1 | synaptotagmin I | -0.0229402 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0226884 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0226871 |
| NAV3 | neuron navigator 3 | -0.0226729 |
| TRAF3 | TNF receptor-associated factor 3 | -0.022654 |
| MTAP | methylthioadenosine phosphorylase | -0.0225987 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0225253 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.022525 |
| RPL37A | ribosomal protein L37a | -0.021786 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0217707 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0217297 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0215801 |
| RNF169 | ring finger protein 169 | -0.0215306 |
| SERPINA2 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) | -0.0215003 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0214917 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0214281 |
| RNF130 | ring finger protein 130 | -0.0212622 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0212371 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | -0.0211263 |
