| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | 0.158729 |
| LSAMP | limbic system-associated membrane protein | 0.121925 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0979352 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0902441 |
| TLE4 | transducin-like enhancer of split 4 | 0.0683028 |
| PLPP1 | phospholipid phosphatase 1 | 0.061092 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | 0.0575284 |
| VMP1 | vacuole membrane protein 1 | 0.0567684 |
| GLCCI1 | glucocorticoid induced 1 | 0.0565761 |
| DST | dystonin | 0.0496889 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0483166 |
| MEIS2 | Meis homeobox 2 | 0.0444147 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0414734 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0404645 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0397348 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | 0.0392631 |
| KLHL13 | kelch-like family member 13 | 0.0384276 |
| GREM2 | gremlin 2, DAN family BMP antagonist | 0.0372585 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0371592 |
| TPM1 | tropomyosin 1 (alpha) | 0.0370639 |
| FN1 | fibronectin 1 | 0.0354245 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0354101 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0346363 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0333051 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0329242 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.0326931 |
| EGR1 | early growth response 1 | 0.0308055 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0306478 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0305119 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0304073 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0303766 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0302457 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0301536 |
| PHF3 | PHD finger protein 3 | 0.0298459 |
| TENM4 | teneurin transmembrane protein 4 | 0.0289507 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0286328 |
| FMN1 | formin 1 | 0.0285053 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0284685 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0284107 |
| AHR | aryl hydrocarbon receptor | 0.028054 |
| FERMT2 | fermitin family member 2 | 0.0272369 |
| TPM4 | tropomyosin 4 | 0.0271319 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0270878 |
| FNIP1 | folliculin interacting protein 1 | 0.0269149 |
| RAB30 | RAB30, member RAS oncogene family | 0.0268395 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0267436 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0264513 |
| RALYL | RALY RNA binding protein-like | 0.0264351 |
| FAM107B | family with sequence similarity 107, member B | 0.0263522 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0261814 |
| ATM | ATM serine/threonine kinase | 0.0256948 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | 0.0251942 |
| PRKCA | protein kinase C, alpha | 0.0249429 |
| ATRNL1 | attractin-like 1 | 0.0246333 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0245275 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0240422 |
| THBS1 | thrombospondin 1 | 0.0239591 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0235159 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0232482 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0227218 |
| HDX | highly divergent homeobox | 0.022578 |
| TET1 | tet methylcytosine dioxygenase 1 | 0.0225271 |
| SEPTIN9 | septin 9 | 0.0224797 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0223436 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0219347 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0217915 |
| IL6ST | interleukin 6 signal transducer | 0.0217557 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0216967 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0213291 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0212699 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0211036 |
| VCP | valosin containing protein | 0.0209696 |
| HAND2 | heart and neural crest derivatives expressed 2 | 0.0208317 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0208302 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0208207 |
| EXOC4 | exocyst complex component 4 | 0.0207725 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0207264 |
| NBEA | neurobeachin | 0.0206559 |
| COL3A1 | collagen, type III, alpha 1 | 0.0206335 |
| HOMER1 | homer scaffolding protein 1 | 0.0205696 |
| UNC5C | unc-5 homolog C (C. elegans) | 0.0203447 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0203212 |
| UBAP2 | ubiquitin associated protein 2 | 0.0201191 |
| KCNIP4 | Kv channel interacting protein 4 | 0.0200384 |
| MRTFA | myocardin related transcription factor A | 0.0200174 |
| MDM4 | MDM4, p53 regulator | 0.0198751 |
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | 0.019857 |
| SIK2 | salt-inducible kinase 2 | 0.0197715 |
| RGS5 | regulator of G-protein signaling 5 | 0.0196816 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0195486 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0195435 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0195268 |
| PALLD | palladin, cytoskeletal associated protein | 0.0194939 |
| MBTD1 | mbt domain containing 1 | 0.0194803 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0194412 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0193578 |
| CCDC57 | coiled-coil domain containing 57 | 0.0193534 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0193352 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | 0.0192527 |
| PCDH9 | protocadherin 9 | 0.0188175 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.27563 |
| IGF2 | insulin-like growth factor 2 | -0.220829 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0929042 |
| PTMA | prothymosin, alpha | -0.0820418 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.078426 |
| MAP1B | microtubule-associated protein 1B | -0.0758798 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0734537 |
| RPS6 | ribosomal protein S6 | -0.066073 |
| RPL23 | ribosomal protein L23 | -0.0639416 |
| TMSB10 | thymosin beta 10 | -0.057325 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0554381 |
| NDRG1 | N-myc downstream regulated 1 | -0.052287 |
| COL1A1 | collagen, type I, alpha 1 | -0.0504559 |
| RPL19 | ribosomal protein L19 | -0.0498569 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0473497 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0454262 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0436914 |
| DTNA | dystrobrevin, alpha | -0.0410127 |
| VIM | vimentin | -0.0393429 |
| RPL35A | ribosomal protein L35a | -0.038564 |
| FTL | ferritin, light polypeptide | -0.0385439 |
| RPL34 | ribosomal protein L34 | -0.0380525 |
| CDK12 | cyclin-dependent kinase 12 | -0.0352254 |
| RTN4 | reticulon 4 | -0.0349324 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0345052 |
| RPS19 | ribosomal protein S19 | -0.0344037 |
| BBX | bobby sox homolog (Drosophila) | -0.0337856 |
| USP3 | ubiquitin specific peptidase 3 | -0.0331699 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0320543 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0320309 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0317826 |
| RPL32 | ribosomal protein L32 | -0.0316201 |
| RBM25 | RNA binding motif protein 25 | -0.0312217 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0310266 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.03052 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0304858 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0303854 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0300342 |
| TRIB2 | tribbles pseudokinase 2 | -0.0295351 |
| RPS3 | ribosomal protein S3 | -0.0292679 |
| RPS14 | ribosomal protein S14 | -0.0286134 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0282707 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0281577 |
| RPL26 | ribosomal protein L26 | -0.0281228 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0280726 |
| HELZ | helicase with zinc finger | -0.0280634 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0279773 |
| ANKRD17 | ankyrin repeat domain 17 | -0.027819 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0274238 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0272252 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0271479 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0269926 |
| RPS29 | ribosomal protein S29 | -0.0266605 |
| RACK1 | receptor for activated C kinase 1 | -0.0265627 |
| TNPO1 | transportin 1 | -0.0263401 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0262647 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0262629 |
| GOLGA4 | golgin A4 | -0.0257899 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.025517 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0253904 |
| QKI | QKI, KH domain containing, RNA binding | -0.025381 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0251047 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0250899 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0247538 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0247323 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0245701 |
| RPS25 | ribosomal protein S25 | -0.024298 |
| PKM | pyruvate kinase, muscle | -0.0241349 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0239903 |
| RPS8 | ribosomal protein S8 | -0.0238704 |
| NF1 | neurofibromin 1 | -0.0236795 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.023612 |
| PTK2 | protein tyrosine kinase 2 | -0.0235996 |
| LPIN1 | lipin 1 | -0.023502 |
| CRH | corticotropin releasing hormone | -0.023434 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.0228832 |
| RBM20 | RNA binding motif protein 20 | -0.022731 |
| RPL31 | ribosomal protein L31 | -0.0227006 |
| RPS21 | ribosomal protein S21 | -0.021986 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0219345 |
| WRN | Werner syndrome, RecQ helicase-like | -0.0219084 |
| RPS24 | ribosomal protein S24 | -0.0219003 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0216951 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0215509 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0215287 |
| AFF3 | AF4/FMR2 family, member 3 | -0.021469 |
| CTBP2 | C-terminal binding protein 2 | -0.0212366 |
| CCNI | cyclin I | -0.0210928 |
| CBX3 | chromobox homolog 3 | -0.021044 |
| ZNF804A | zinc finger protein 804A | -0.0210086 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0208273 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0207932 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0207548 |
| NBAS | neuroblastoma amplified sequence | -0.0207339 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0207236 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0206252 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0205222 |
| ZNF148 | zinc finger protein 148 | -0.0204545 |
| FMNL2 | formin-like 2 | -0.0204332 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0203148 |
