Tofacitinib_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tofacitinib perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tofacitinib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.172376
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.124258
VCL vinculin 0.0968194
LMO7 LIM domain 7 0.0914087
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0738849
SMAD3 SMAD family member 3 0.0728061
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0717781
MYO1E myosin IE 0.0643852
AKAP13 A kinase (PRKA) anchor protein 13 0.0613748
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0607664
ANXA2 annexin A2 0.0581323
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0576023
INTS6 integrator complex subunit 6 0.056919
TOX3 TOX high mobility group box family member 3 0.0525218
VMP1 vacuole membrane protein 1 0.0416411
MSI2 musashi RNA-binding protein 2 0.0413003
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0407726
PDLIM5 PDZ and LIM domain 5 0.0402114
MACC1 metastasis associated in colon cancer 1 0.0400582
ITGA6 integrin, alpha 6 0.0367801
EFNB2 ephrin-B2 0.0345373
AREG amphiregulin 0.0339282
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0329694
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.0310106
TNS4 tensin 4 0.0301879
TJP1 tight junction protein 1 0.0291649
SHB Src homology 2 domain containing adaptor protein B 0.0290554
DSCAM Down syndrome cell adhesion molecule 0.027917
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0266457
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0262205
CTBP2 C-terminal binding protein 2 0.0257167
ZSWIM6 zinc finger, SWIM-type containing 6 0.0251826
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0250326
EPS8 epidermal growth factor receptor pathway substrate 8 0.02371
SPRED1 sprouty-related, EVH1 domain containing 1 0.023216
LURAP1L leucine rich adaptor protein 1-like 0.022882
TM4SF19 transmembrane 4 L six family member 19 0.0213336
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0212302
CLOCK clock circadian regulator 0.0212276
ERBIN erbb2 interacting protein 0.0211307
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0211105
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0208141
SLK STE20-like kinase 0.0206447
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.020586
ATXN1 ataxin 1 0.0205819
CEMIP cell migration inducing protein, hyaluronan binding 0.0205455
RUNX1 runt-related transcription factor 1 0.020338
KYNU kynureninase 0.0198596
EREG epiregulin 0.0197655
FNIP1 folliculin interacting protein 1 0.0196837
ZNF292 zinc finger protein 292 0.0189596
LIPH lipase, member H 0.0181649
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0179691
NCEH1 neutral cholesterol ester hydrolase 1 0.0178397
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0176532
POF1B premature ovarian failure, 1B 0.0176173
PADI1 peptidyl arginine deiminase, type I 0.0171466
RCOR1 REST corepressor 1 0.0169129
BCL2L1 BCL2-like 1 0.0168069
TUFT1 tuftelin 1 0.0167154
EZR ezrin 0.01656
ARHGAP26 Rho GTPase activating protein 26 0.0162962
SPAG9 sperm associated antigen 9 0.0161782
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0160314
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0159441
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.015902
DUSP10 dual specificity phosphatase 10 0.0158939
MCTP1 multiple C2 domains, transmembrane 1 0.0158129
BAIAP2L1 BAI1-associated protein 2-like 1 0.0157949
HKDC1 hexokinase domain containing 1 0.0156984
MED13 mediator complex subunit 13 0.0155041
DPP4 dipeptidyl-peptidase 4 0.01545
MPRIP myosin phosphatase Rho interacting protein 0.0153893
MLPH melanophilin 0.0151295
ECT2 epithelial cell transforming 2 0.0147382
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.014734
FAM120A family with sequence similarity 120A 0.0147224
RDH10 retinol dehydrogenase 10 (all-trans) 0.0146647
TRIM2 tripartite motif containing 2 0.0146634
PRELID2 PRELI domain containing 2 0.01465
GCLC glutamate-cysteine ligase, catalytic subunit 0.0146068
DST dystonin 0.0145196
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0142896
PDE4D phosphodiesterase 4D, cAMP-specific 0.0142891
ABHD2 abhydrolase domain containing 2 0.0142726
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0142043
YAP1 Yes-associated protein 1 0.0137259
ITGB8 integrin, beta 8 0.0136916
FNIP2 folliculin interacting protein 2 0.0136536
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0134742
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0133899
ETV6 ets variant 6 0.013385
RAB7A RAB7A, member RAS oncogene family 0.0125331
EML4 echinoderm microtubule associated protein like 4 0.0124876
EFHC1 EF-hand domain (C-terminal) containing 1 0.0122019
RAD51B RAD51 paralog B 0.0121835
DYNLT2B dynein light chain Tctex-type 2B 0.0121741
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0121606
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 0.0120966
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0119396

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.0877909
EPSTI1 epithelial stromal interaction 1 (breast) -0.087693
B2M beta-2-microglobulin -0.0783282
ZMYND8 zinc finger, MYND-type containing 8 -0.0735526
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0672593
PTMA prothymosin, alpha -0.0639207
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0558996
RNF213 ring finger protein 213 -0.0524436
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0502312
RPS6 ribosomal protein S6 -0.0489377
RIGI RNA sensor RIG-I -0.0453451
HLA-B major histocompatibility complex, class I, B -0.0440179
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0434019
SP100 SP100 nuclear antigen -0.0417712
NDRG1 N-myc downstream regulated 1 -0.0417338
RPL23 ribosomal protein L23 -0.0405238
XAF1 XIAP associated factor 1 -0.039141
MX1 MX dynamin-like GTPase 1 -0.0378744
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0349043
LYZ lysozyme -0.0337944
RPL35A ribosomal protein L35a -0.0337914
EIF1 eukaryotic translation initiation factor 1 -0.0325813
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.031415
ENO1 enolase 1, (alpha) -0.0307605
LCN2 lipocalin 2 -0.0300296
TXNIP thioredoxin interacting protein -0.0300286
MX2 MX dynamin-like GTPase 2 -0.0292071
PGK1 phosphoglycerate kinase 1 -0.0289495
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0288468
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0287716
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0283291
RPL34 ribosomal protein L34 -0.0277462
FTL ferritin, light polypeptide -0.0267083
IFI6 interferon, alpha-inducible protein 6 -0.0260555
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0257198
TMSB10 thymosin beta 10 -0.0256215
RPLP1 ribosomal protein, large, P1 -0.0251203
RPS12 ribosomal protein S12 -0.0250138
RPL12 ribosomal protein L12 -0.0248641
H1-0 H1.0 linker histone -0.0246421
RRBP1 ribosome binding protein 1 -0.0246299
PLSCR2 phospholipid scramblase 2 -0.0243365
HLA-E major histocompatibility complex, class I, E -0.0238765
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0226697
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0226134
BTBD9 BTB (POZ) domain containing 9 -0.0225898
RPS27 ribosomal protein S27 -0.022474
RPL37A ribosomal protein L37a -0.0221638
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0218039
RPS3 ribosomal protein S3 -0.0218
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0217949
LOC112694756 uncharaterized LOC112694756 -0.021659
PDIA3 protein disulfide isomerase family A, member 3 -0.0214585
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0213927
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0213057
RPS19 ribosomal protein S19 -0.0212465
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0208386
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0206944
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0206473
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0206223
RPL26 ribosomal protein L26 -0.0203847
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0203225
RPL7L1 ribosomal protein L7-like 1 -0.0202865
RNF149 ring finger protein 149 -0.0202467
RPL31 ribosomal protein L31 -0.0201368
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0200315
TFF3 trefoil factor 3 (intestinal) -0.0197747
RHOBTB3 Rho-related BTB domain containing 3 -0.0196023
RPLP0 ribosomal protein, large, P0 -0.019552
RPL19 ribosomal protein L19 -0.0195248
MPHOSPH8 M-phase phosphoprotein 8 -0.0195126
CANX calnexin -0.0192914
ZMYM2 zinc finger, MYM-type 2 -0.0192683
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0189929
STS steroid sulfatase (microsomal), isozyme S -0.018718
GNAS GNAS complex locus -0.0186128
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0185687
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0182745
TPI1 triosephosphate isomerase 1 -0.0182593
TMC5 transmembrane channel-like 5 -0.018213
ADAR adenosine deaminase, RNA-specific -0.018205
PLSCR1 phospholipid scramblase 1 -0.018116
HLA-A major histocompatibility complex, class I, A -0.0180481
RPS8 ribosomal protein S8 -0.017947
CALR calreticulin -0.0177556
EPCAM epithelial cell adhesion molecule -0.0177506
RPL37 ribosomal protein L37 -0.0176174
HLA-C major histocompatibility complex, class I, C -0.0176128
PTEN phosphatase and tensin homolog -0.0175712
PRRC2C proline-rich coiled-coil 2C -0.0174301
S100A6 S100 calcium binding protein A6 -0.0173992
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0168462
WDR45B WD repeat domain 45B -0.0167733
RPL36A ribosomal protein L36a -0.0167319
LDHA lactate dehydrogenase A -0.0166418
RPS29 ribosomal protein S29 -0.0164366
PTGR1 prostaglandin reductase 1 -0.0162191
S100A9 S100 calcium binding protein A9 -0.0160416
NPEPPS aminopeptidase puromycin sensitive -0.0159226
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa -0.015911