| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0988546 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0927962 |
| CADM1 | cell adhesion molecule 1 | 0.0761754 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0588342 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0391302 |
| COPA | coatomer protein complex, subunit alpha | 0.0360449 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0321918 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.032162 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0316569 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0314144 |
| VCL | vinculin | 0.0310155 |
| ATP13A3 | ATPase type 13A3 | 0.030803 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0301252 |
| HDAC9 | histone deacetylase 9 | 0.0292473 |
| EGFR | epidermal growth factor receptor | 0.0273472 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0259992 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0253329 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0247458 |
| CALD1 | caldesmon 1 | 0.0246388 |
| QKI | QKI, KH domain containing, RNA binding | 0.0244939 |
| PCBP2 | poly(rC) binding protein 2 | 0.0242275 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0241056 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0232801 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0232067 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0220099 |
| RNF145 | ring finger protein 145 | 0.0219896 |
| GOLGA4 | golgin A4 | 0.0219252 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0218342 |
| TFG | TRK-fused gene | 0.0215419 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0214697 |
| FNIP1 | folliculin interacting protein 1 | 0.0212593 |
| DSTN | destrin (actin depolymerizing factor) | 0.0210634 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0209432 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0208331 |
| HMCN1 | hemicentin 1 | 0.0207473 |
| MYADM | myeloid-associated differentiation marker | 0.020725 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0206215 |
| ITGAV | integrin, alpha V | 0.0205447 |
| RBM39 | RNA binding motif protein 39 | 0.0203564 |
| EPHB1 | EPH receptor B1 | 0.0199799 |
| WASF2 | WAS protein family, member 2 | 0.0199784 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0195698 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0193736 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0191524 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0190696 |
| BBX | bobby sox homolog (Drosophila) | 0.0189903 |
| HELZ | helicase with zinc finger | 0.0188799 |
| SPAG9 | sperm associated antigen 9 | 0.0187766 |
| HMGA2 | high mobility group AT-hook 2 | 0.0187695 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0187089 |
| COG6 | component of oligomeric golgi complex 6 | 0.0185284 |
| LOX | lysyl oxidase | 0.018389 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0181518 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0181172 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0178375 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0177372 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0174805 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0174724 |
| SETD5 | SET domain containing 5 | 0.0174696 |
| KLF12 | Kruppel-like factor 12 | 0.0173457 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0173116 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0171137 |
| NBAS | neuroblastoma amplified sequence | 0.0170834 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0170376 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0169883 |
| PFN1 | profilin 1 | 0.0169551 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0169351 |
| FMNL2 | formin-like 2 | 0.0167158 |
| SRSF3 | serine/arginine-rich splicing factor 3 | 0.0164897 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0163657 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0163504 |
| JMJD1C | jumonji domain containing 1C | 0.0162652 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0162085 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0161942 |
| CCNL1 | cyclin L1 | 0.0160872 |
| DST | dystonin | 0.0159982 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0159632 |
| HYOU1 | hypoxia up-regulated 1 | 0.0158908 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0158343 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | 0.0158142 |
| PDE8A | phosphodiesterase 8A | 0.0157745 |
| NEK10 | NIMA-related kinase 10 | 0.0157613 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0155918 |
| FNBP4 | formin binding protein 4 | 0.015553 |
| MYOF | myoferlin | 0.015304 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0151999 |
| SFPQ | splicing factor proline/glutamine-rich | 0.015179 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0150831 |
| TNPO1 | transportin 1 | 0.0150557 |
| PRR16 | proline rich 16 | 0.0149495 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0149489 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0148792 |
| PCM1 | pericentriolar material 1 | 0.014718 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0146583 |
| PTK2 | protein tyrosine kinase 2 | 0.0146095 |
| ZNF638 | zinc finger protein 638 | 0.0145728 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0144926 |
| APAF1 | apoptotic peptidase activating factor 1 | 0.014475 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0144544 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0144419 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.227447 |
| MT2A | metallothionein 2A | -0.200295 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.189272 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.172098 |
| CD44 | CD44 molecule (Indian blood group) | -0.115556 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0961218 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0934999 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0849163 |
| STC1 | stanniocalcin 1 | -0.0805086 |
| LOXL2 | lysyl oxidase-like 2 | -0.0793606 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0715253 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0694705 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0687478 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0651986 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0648166 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0594053 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.05843 |
| CALR | calreticulin | -0.0538272 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0499902 |
| TMSB10 | thymosin beta 10 | -0.0497989 |
| OSMR | oncostatin M receptor | -0.0494244 |
| ENO1 | enolase 1, (alpha) | -0.0489896 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0487463 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.048686 |
| RIGI | RNA sensor RIG-I | -0.0474069 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.046427 |
| IER3 | immediate early response 3 | -0.0451351 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0436176 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0428302 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0424172 |
| VIM | vimentin | -0.0423 |
| HLA-B | major histocompatibility complex, class I, B | -0.0415028 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0404767 |
| TMSB4X | thymosin beta 4, X-linked | -0.0400709 |
| COL1A1 | collagen, type I, alpha 1 | -0.0400226 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0395994 |
| INHBA | inhibin, beta A | -0.0391947 |
| AHNAK | AHNAK nucleoprotein | -0.0381507 |
| COL1A2 | collagen, type I, alpha 2 | -0.0377733 |
| MTSS1 | metastasis suppressor 1 | -0.0376721 |
| APP | amyloid beta (A4) precursor protein | -0.0376711 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0376199 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0370362 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0359137 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0355687 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0344083 |
| IL6 | interleukin 6 | -0.0343354 |
| RPS8 | ribosomal protein S8 | -0.0334468 |
| B2M | beta-2-microglobulin | -0.0332755 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0331627 |
| COL3A1 | collagen, type III, alpha 1 | -0.0326114 |
| HAS2 | hyaluronan synthase 2 | -0.0322363 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0304584 |
| MT1X | metallothionein 1X | -0.0304381 |
| S100A9 | S100 calcium binding protein A9 | -0.0303605 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0302286 |
| IL6ST | interleukin 6 signal transducer | -0.0297342 |
| RPS2 | ribosomal protein S2 | -0.0291212 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0291048 |
| CANX | calnexin | -0.0285374 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0284151 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0283801 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0283078 |
| CTSB | cathepsin B | -0.028218 |
| COL5A1 | collagen, type V, alpha 1 | -0.0274732 |
| PLSCR1 | phospholipid scramblase 1 | -0.0269706 |
| CDH13 | cadherin 13 | -0.0267982 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0267098 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0266485 |
| RND3 | Rho family GTPase 3 | -0.0264811 |
| RPL12 | ribosomal protein L12 | -0.0260671 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0256833 |
| RRBP1 | ribosome binding protein 1 | -0.0255465 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.025186 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0251802 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0251624 |
| MX2 | MX dynamin-like GTPase 2 | -0.0249824 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0248557 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0248197 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0246038 |
| RPL30 | ribosomal protein L30 | -0.0245285 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0244311 |
| PLEC | plectin | -0.02388 |
| CAVIN1 | caveolae associated protein 1 | -0.0238571 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0236262 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0231588 |
| SP100 | SP100 nuclear antigen | -0.0231584 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0229836 |
| TPM4 | tropomyosin 4 | -0.022934 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0228808 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0225244 |
| S100A10 | S100 calcium binding protein A10 | -0.022417 |
| NAV1 | neuron navigator 1 | -0.0219369 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0217618 |
| RPL34 | ribosomal protein L34 | -0.0215875 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0215762 |
| RPS3 | ribosomal protein S3 | -0.0210207 |
| DUSP6 | dual specificity phosphatase 6 | -0.020934 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0207834 |
| RPL26 | ribosomal protein L26 | -0.020665 |
