Tofacitinib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tofacitinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tofacitinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.199856
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.193472
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.181477
SAMD4A sterile alpha motif domain containing 4A 0.134497
FN1 fibronectin 1 0.0981162
APOB apolipoprotein B 0.0942852
PDLIM5 PDZ and LIM domain 5 0.0905996
ATXN1 ataxin 1 0.0782844
ITGAV integrin, alpha V 0.0612402
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0602023
MACF1 microtubule-actin crosslinking factor 1 0.0591626
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.057577
DOCK4 dedicator of cytokinesis 4 0.0571633
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0568449
LRMDA leucine rich melanocyte differentiation associated 0.052188
SPATS2L spermatogenesis associated, serine-rich 2-like 0.052043
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0518386
DSPP dentin sialophosphoprotein 0.0514059
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0491986
VCL vinculin 0.0490717
FMNL2 formin-like 2 0.0475052
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0462478
SVIL supervillin 0.0461456
ADGRG6 adhesion G protein-coupled receptor G6 0.0430485
MAML2 mastermind-like 2 (Drosophila) 0.0423874
DLC1 DLC1 Rho GTPase activating protein 0.0412515
PTCHD4 patched domain containing 4 0.0410222
AFDN afadin, adherens junction formation factor 0.0405983
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.040481
GMDS GDP-mannose 4,6-dehydratase 0.0392231
SORBS1 sorbin and SH3 domain containing 1 0.0386722
MALT1 MALT1 paracaspase 0.0376064
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0363086
PLIN2 perilipin 2 0.0361703
PKP4 plakophilin 4 0.0354468
PAWR PRKC, apoptosis, WT1, regulator 0.0353802
NRIP1 nuclear receptor interacting protein 1 0.0349396
DST dystonin 0.0347831
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0339696
MBNL2 muscleblind-like splicing regulator 2 0.0336287
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0314388
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0311698
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0305334
LMCD1 LIM and cysteine-rich domains 1 0.0304005
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0299491
OSBPL3 oxysterol binding protein-like 3 0.0275098
SH3RF1 SH3 domain containing ring finger 1 0.0267593
ARHGAP18 Rho GTPase activating protein 18 0.0267204
MBNL3 muscleblind-like splicing regulator 3 0.0265813
ESYT2 extended synaptotagmin-like protein 2 0.0257156
GLS2 glutaminase 2 (liver, mitochondrial) 0.0254239
TBC1D22A TBC1 domain family, member 22A 0.0252903
RUNX1 runt-related transcription factor 1 0.0252341
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.0251224
FRMD5 FERM domain containing 5 0.0250784
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.024707
SMAD3 SMAD family member 3 0.0245176
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0245066
LIMS1 LIM and senescent cell antigen-like domains 1 0.024271
NKD1 naked cuticle homolog 1 (Drosophila) 0.0240928
ARHGAP9 Rho GTPase activating protein 9 0.0239215
SEC31A SEC31 homolog A (S. cerevisiae) 0.0238487
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.0236146
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0235746
ITCH itchy E3 ubiquitin protein ligase 0.0234946
ITGB5 integrin, beta 5 0.023456
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0230623
WDFY2 WD repeat and FYVE domain containing 2 0.0226801
CNKSR3 CNKSR family member 3 0.0222977
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0220676
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0215721
FAM107B family with sequence similarity 107, member B 0.0215495
EPS8 epidermal growth factor receptor pathway substrate 8 0.0214376
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0212994
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0211952
MYH9 myosin, heavy chain 9, non-muscle 0.0209263
ZBTB20 zinc finger and BTB domain containing 20 0.0208282
PTPRM protein tyrosine phosphatase, receptor type, M 0.0206998
OSBPL8 oxysterol binding protein-like 8 0.0206708
DAAM1 dishevelled associated activator of morphogenesis 1 0.0205047
PDGFB platelet-derived growth factor beta polypeptide 0.0205015
ABLIM1 actin binding LIM protein 1 0.0205014
AHR aryl hydrocarbon receptor 0.0203517
IGF1R insulin-like growth factor 1 receptor 0.0202261
RBM25 RNA binding motif protein 25 0.0202195
SEC24D SEC24 family member D 0.0200433
STRN3 striatin, calmodulin binding protein 3 0.0200342
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 0.0199008
FNDC3B fibronectin type III domain containing 3B 0.0196943
PEG10 paternally expressed 10 0.0196093
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.019531
PLAC8 placenta-specific 8 0.0195059
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0192937
OSBPL10 oxysterol binding protein-like 10 0.0192533
TTC3 tetratricopeptide repeat domain 3 0.0192377
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0190578
ARHGAP5 Rho GTPase activating protein 5 0.0189332
ERLEC1 endoplasmic reticulum lectin 1 0.0188649
NHSL1 NHS-like 1 0.0187093
SRRM1 serine/arginine repetitive matrix 1 0.018685

decreased expression

Symbol Name Standardized Value
RPL37A ribosomal protein L37a -0.105836
GPC6 glypican 6 -0.0980824
RPS6 ribosomal protein S6 -0.0980697
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.093819
AHSG alpha-2-HS-glycoprotein -0.0854722
RPS8 ribosomal protein S8 -0.0815183
APOA2 apolipoprotein A-II -0.0793367
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.07603
RPL31 ribosomal protein L31 -0.0742847
RPL35A ribosomal protein L35a -0.0715174
RPS12 ribosomal protein S12 -0.0706183
RPL23 ribosomal protein L23 -0.069898
TPT1 tumor protein, translationally-controlled 1 -0.0687639
RPS3 ribosomal protein S3 -0.0667073
SLC38A2 solute carrier family 38, member 2 -0.0630384
TF transferrin -0.0599257
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0597396
PTMA prothymosin, alpha -0.05956
RPS29 ribosomal protein S29 -0.0583796
RPS24 ribosomal protein S24 -0.0563733
RPL34 ribosomal protein L34 -0.0543285
DTNA dystrobrevin, alpha -0.0538554
RPS27A ribosomal protein S27a -0.0528623
RPL11 ribosomal protein L11 -0.0525781
NDRG1 N-myc downstream regulated 1 -0.0523278
RPS13 ribosomal protein S13 -0.0518244
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0512689
MT2A metallothionein 2A -0.0508022
RPS19 ribosomal protein S19 -0.0503153
CP ceruloplasmin (ferroxidase) -0.0495992
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0487494
GNAS GNAS complex locus -0.0480255
RPLP1 ribosomal protein, large, P1 -0.0471248
RPL5 ribosomal protein L5 -0.046858
FTL ferritin, light polypeptide -0.0459708
ENO1 enolase 1, (alpha) -0.0449507
EIF1 eukaryotic translation initiation factor 1 -0.0442474
SP100 SP100 nuclear antigen -0.0439834
RPS14 ribosomal protein S14 -0.0434278
RPL26 ribosomal protein L26 -0.0423884
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0417063
RPL37 ribosomal protein L37 -0.0411489
RPS17 ribosomal protein S17 -0.0410622
TMSB10 thymosin beta 10 -0.0409893
VEGFA vascular endothelial growth factor A -0.0399185
APOE apolipoprotein E -0.0391477
RPL7A ribosomal protein L7a -0.0385909
APOA1 apolipoprotein A-I -0.0385212
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0382901
IGFBP1 insulin-like growth factor binding protein 1 -0.0379455
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0378273
RPL9 ribosomal protein L9 -0.0369642
RPS25 ribosomal protein S25 -0.036874
ETFB electron-transfer-flavoprotein, beta polypeptide -0.0364937
RACK1 receptor for activated C kinase 1 -0.0358174
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0357458
B2M beta-2-microglobulin -0.0351042
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0346853
RIGI RNA sensor RIG-I -0.0336165
RPS11 ribosomal protein S11 -0.0329872
AMBP alpha-1-microglobulin/bikunin precursor -0.0328313
RPLP2 ribosomal protein, large, P2 -0.032506
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0321153
RPS10 ribosomal protein S10 -0.0317832
RPS27 ribosomal protein S27 -0.0317307
ANKRD10 ankyrin repeat domain 10 -0.0315154
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.0308029
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0307784
RPS23 ribosomal protein S23 -0.0297029
RNF213 ring finger protein 213 -0.0296574
PKM pyruvate kinase, muscle -0.0296178
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0293232
PCBP2 poly(rC) binding protein 2 -0.029224
EEF2 eukaryotic translation elongation factor 2 -0.0285641
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0282778
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0279656
RPS21 ribosomal protein S21 -0.0279108
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0278303
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0276723
ARHGAP21 Rho GTPase activating protein 21 -0.0271891
IFITM1 interferon induced transmembrane protein 1 -0.0271813
NAP1L1 nucleosome assembly protein 1-like 1 -0.0270112
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0269468
RPL15 ribosomal protein L15 -0.0267907
RPL30 ribosomal protein L30 -0.0259808
RPL38 ribosomal protein L38 -0.0253685
S100P S100 calcium binding protein P -0.0253087
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0251597
SESTD1 SEC14 and spectrin domains 1 -0.0251484
TPM4 tropomyosin 4 -0.0251149
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -0.024846
PARD3 par-3 family cell polarity regulator -0.0247472
RPS20 ribosomal protein S20 -0.0247392
TM4SF1 transmembrane 4 L six family member 1 -0.0245172
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0240396
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0237452
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0234364
IFI6 interferon, alpha-inducible protein 6 -0.0233809
NACA nascent polypeptide-associated complex alpha subunit -0.0233013
HSPA1A heat shock 70kDa protein 1A -0.0232095