| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ARHGAP29 | Rho GTPase activating protein 29 | 0.060489 |
| DST | dystonin | 0.0531615 |
| SMAD3 | SMAD family member 3 | 0.0521839 |
| VCL | vinculin | 0.0510573 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0442306 |
| AOPEP | aminopeptidase O (putative) | 0.0430291 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0395424 |
| MYOF | myoferlin | 0.0390285 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0389102 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.0376137 |
| SH3PXD2A | SH3 and PX domains 2A | 0.0367492 |
| FRMD6 | FERM domain containing 6 | 0.0366826 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0360594 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0346824 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0346261 |
| TXNRD1 | thioredoxin reductase 1 | 0.0344828 |
| ITGA6 | integrin, alpha 6 | 0.0341476 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0330657 |
| BLCAP | bladder cancer associated protein | 0.0329047 |
| DIAPH3 | diaphanous-related formin 3 | 0.0291791 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0288392 |
| MYO10 | myosin X | 0.0277894 |
| NRG1 | neuregulin 1 | 0.0274653 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.0274477 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.0267657 |
| AMOTL1 | angiomotin like 1 | 0.0257766 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0256259 |
| BCL2L1 | BCL2-like 1 | 0.0252583 |
| JAG1 | jagged 1 | 0.0251371 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0249466 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0245449 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.024408 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0241642 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0240881 |
| PCBP2 | poly(rC) binding protein 2 | 0.0239398 |
| CENPF | centromere protein F, 350/400kDa | 0.0237025 |
| KIAA1217 | KIAA1217 | 0.0235744 |
| COG5 | component of oligomeric golgi complex 5 | 0.0234869 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0234797 |
| METTL15 | methyltransferase like 15 | 0.0233768 |
| FRYL | FRY-like | 0.0232626 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0231409 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0229323 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0228434 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.022823 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0223877 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0221467 |
| NBEA | neurobeachin | 0.0216387 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0216163 |
| USP47 | ubiquitin specific peptidase 47 | 0.0215825 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0215276 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0211317 |
| DIDO1 | death inducer-obliterator 1 | 0.0210841 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0210054 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0205855 |
| BARX2 | BARX homeobox 2 | 0.0205243 |
| ATXN1 | ataxin 1 | 0.0204654 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0203613 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0203537 |
| EXOC6B | exocyst complex component 6B | 0.0202488 |
| SLTM | SAFB-like, transcription modulator | 0.0200784 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0199762 |
| ASPH | aspartate beta-hydroxylase | 0.0198624 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0196664 |
| PRELID2 | PRELI domain containing 2 | 0.0195362 |
| HELZ | helicase with zinc finger | 0.0193935 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0191998 |
| TOP1 | topoisomerase (DNA) I | 0.0187681 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0187612 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0186089 |
| VMP1 | vacuole membrane protein 1 | 0.0185501 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0181561 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0180118 |
| PHF20L1 | PHD finger protein 20-like 1 | 0.01781 |
| LPAR1 | lysophosphatidic acid receptor 1 | 0.0172896 |
| MECOM | MDS1 and EVI1 complex locus | 0.0172677 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0171795 |
| HMGA2 | high mobility group AT-hook 2 | 0.017152 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0169667 |
| EFNB2 | ephrin-B2 | 0.016928 |
| FNIP1 | folliculin interacting protein 1 | 0.0167195 |
| KLF12 | Kruppel-like factor 12 | 0.0166687 |
| EGFR | epidermal growth factor receptor | 0.0165493 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.016537 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0165034 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0163834 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.0163091 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0161753 |
| PDE8A | phosphodiesterase 8A | 0.0161725 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0161233 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0160696 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.016029 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.016017 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0159765 |
| SETX | senataxin | 0.0159293 |
| SCFD1 | sec1 family domain containing 1 | 0.0158229 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0156649 |
| MSN | moesin | 0.0155289 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0154426 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0154369 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.346505 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.17924 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.157495 |
| MTSS1 | metastasis suppressor 1 | -0.147545 |
| B2M | beta-2-microglobulin | -0.107563 |
| NDRG1 | N-myc downstream regulated 1 | -0.105201 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0970793 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0866474 |
| EMP1 | epithelial membrane protein 1 | -0.0855765 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0846734 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0834356 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0815917 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.081377 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0794542 |
| ENO1 | enolase 1, (alpha) | -0.0780987 |
| RPS6 | ribosomal protein S6 | -0.0764151 |
| AHNAK | AHNAK nucleoprotein | -0.0762406 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0760272 |
| TMSB4X | thymosin beta 4, X-linked | -0.0744404 |
| LMO7 | LIM domain 7 | -0.0722333 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0721652 |
| IFI44L | interferon-induced protein 44-like | -0.070298 |
| RPS8 | ribosomal protein S8 | -0.0698943 |
| SP100 | SP100 nuclear antigen | -0.0689887 |
| SULF2 | sulfatase 2 | -0.0680406 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0677796 |
| S100A10 | S100 calcium binding protein A10 | -0.0669164 |
| HLA-B | major histocompatibility complex, class I, B | -0.065818 |
| LDHA | lactate dehydrogenase A | -0.0652142 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0634067 |
| HLA-E | major histocompatibility complex, class I, E | -0.0632909 |
| MT2A | metallothionein 2A | -0.063261 |
| ANXA1 | annexin A1 | -0.0621771 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0609074 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0593903 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0582828 |
| RIGI | RNA sensor RIG-I | -0.0560272 |
| TMSB10 | thymosin beta 10 | -0.0547834 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.053765 |
| FLNB | filamin B, beta | -0.0535878 |
| STC1 | stanniocalcin 1 | -0.0526897 |
| PTMA | prothymosin, alpha | -0.052615 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.05183 |
| PGK1 | phosphoglycerate kinase 1 | -0.0508826 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0508589 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0497854 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.049171 |
| OSMR | oncostatin M receptor | -0.0490384 |
| RPL37 | ribosomal protein L37 | -0.0479364 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0477554 |
| DOK5 | docking protein 5 | -0.0476711 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0475717 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0461844 |
| IFI44 | interferon-induced protein 44 | -0.0455677 |
| CLU | clusterin | -0.0445361 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0436573 |
| RAI14 | retinoic acid induced 14 | -0.0423312 |
| H1-0 | H1.0 linker histone | -0.0422499 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.041634 |
| NAV2 | neuron navigator 2 | -0.0413784 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0412033 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0410117 |
| RPS21 | ribosomal protein S21 | -0.0407882 |
| RPS19 | ribosomal protein S19 | -0.0406086 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0395945 |
| LOC112694756 | uncharaterized LOC112694756 | -0.039491 |
| RPS13 | ribosomal protein S13 | -0.0389918 |
| S100A11 | S100 calcium binding protein A11 | -0.0380229 |
| MX1 | MX dynamin-like GTPase 1 | -0.0376767 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.03734 |
| PLSCR1 | phospholipid scramblase 1 | -0.0369169 |
| TRIM56 | tripartite motif containing 56 | -0.0363164 |
| TGM2 | transglutaminase 2 | -0.0356494 |
| PODXL | podocalyxin-like | -0.0354878 |
| RPL12 | ribosomal protein L12 | -0.035423 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | -0.0353558 |
| RPS25 | ribosomal protein S25 | -0.0349829 |
| S100A9 | S100 calcium binding protein A9 | -0.0347418 |
| SQLE | squalene epoxidase | -0.0346061 |
| RPS12 | ribosomal protein S12 | -0.0345225 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0343529 |
| LMNA | lamin A/C | -0.0340741 |
| EZR | ezrin | -0.0337624 |
| MEF2A | myocyte enhancer factor 2A | -0.0337003 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.0331859 |
| CD9 | CD9 molecule | -0.0328251 |
| SULF1 | sulfatase 1 | -0.0327857 |
| TPM4 | tropomyosin 4 | -0.031261 |
| ANXA2 | annexin A2 | -0.0311132 |
| RPL8 | ribosomal protein L8 | -0.0309193 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0306547 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0302461 |
| PRSS23 | protease, serine, 23 | -0.0300891 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0300394 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0300372 |
| ANGPTL4 | angiopoietin-like 4 | -0.0296757 |
| FTL | ferritin, light polypeptide | -0.0296118 |
| RPL35A | ribosomal protein L35a | -0.0295801 |
| LDLR | low density lipoprotein receptor | -0.0294996 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.029266 |
