| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tofacitinib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.131212 |
| FNDC3B | fibronectin type III domain containing 3B | 0.088918 |
| MYOF | myoferlin | 0.0877943 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0810705 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0779419 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0733386 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.073176 |
| TJP1 | tight junction protein 1 | 0.0699493 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0677621 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0597813 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0596523 |
| CAPN8 | calpain 8 | 0.0591157 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0579912 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.056015 |
| MYO1E | myosin IE | 0.0538602 |
| POF1B | premature ovarian failure, 1B | 0.0535827 |
| SLC38A2 | solute carrier family 38, member 2 | 0.051797 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0501178 |
| VMP1 | vacuole membrane protein 1 | 0.0500435 |
| ATXN1 | ataxin 1 | 0.0487612 |
| FBXO11 | F-box protein 11 | 0.0465186 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0454248 |
| SEPTIN9 | septin 9 | 0.044115 |
| LAMA4 | laminin, alpha 4 | 0.0441087 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0438862 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0433268 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0432525 |
| DSPP | dentin sialophosphoprotein | 0.0426579 |
| AREG | amphiregulin | 0.0423722 |
| INTS6 | integrator complex subunit 6 | 0.0419117 |
| CTBP2 | C-terminal binding protein 2 | 0.041647 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0416199 |
| SMAD3 | SMAD family member 3 | 0.0415591 |
| RCOR1 | REST corepressor 1 | 0.0410613 |
| VCL | vinculin | 0.0409216 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0408559 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0398946 |
| SIK3 | SIK family kinase 3 | 0.0395902 |
| EZR | ezrin | 0.0381163 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.037811 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0364503 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | 0.0361786 |
| SNX9 | sorting nexin 9 | 0.0357989 |
| BCL2L1 | BCL2-like 1 | 0.0353161 |
| KRT86 | keratin 86, type II | 0.0350444 |
| GDA | guanine deaminase | 0.0348559 |
| PRKCA | protein kinase C, alpha | 0.0347116 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0344341 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.0344193 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0343667 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0341202 |
| EXOC4 | exocyst complex component 4 | 0.0334695 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0331362 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.0331232 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.0327721 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0322262 |
| ANXA11 | annexin A11 | 0.0318207 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0313234 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0310099 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0302021 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.030186 |
| KLHL29 | kelch-like family member 29 | 0.0301551 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0296791 |
| OXSR1 | oxidative stress responsive 1 | 0.0294953 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.029143 |
| MCU | mitochondrial calcium uniporter | 0.0290665 |
| COBL | cordon-bleu WH2 repeat protein | 0.0290517 |
| SQSTM1 | sequestosome 1 | 0.0290313 |
| TGFA | transforming growth factor, alpha | 0.0289776 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0288911 |
| TES | testin LIM domain protein | 0.0285331 |
| GOLGB1 | golgin B1 | 0.0282987 |
| TNIK | TRAF2 and NCK interacting kinase | 0.0282208 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.027814 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0275091 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0274131 |
| MYO5B | myosin VB | 0.0271921 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0267826 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0266046 |
| MYEOV | myeloma overexpressed | 0.0265546 |
| TRIM2 | tripartite motif containing 2 | 0.0262393 |
| SYNJ2 | synaptojanin 2 | 0.0261086 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.0257709 |
| MED13 | mediator complex subunit 13 | 0.0256963 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0256136 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 0.0256022 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0255335 |
| CDK13 | cyclin-dependent kinase 13 | 0.0254065 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0251901 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0251808 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.024986 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.024765 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0247196 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0245906 |
| AHR | aryl hydrocarbon receptor | 0.0245676 |
| ECT2 | epithelial cell transforming 2 | 0.0243357 |
| TOM1L2 | target of myb1-like 2 (chicken) | 0.0242638 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.02412 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0238426 |
| CNKSR3 | CNKSR family member 3 | 0.0237923 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.110952 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.105396 |
| TMSB10 | thymosin beta 10 | -0.0859557 |
| B2M | beta-2-microglobulin | -0.0829956 |
| AGR3 | anterior gradient 3 | -0.0661586 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.064447 |
| PGK1 | phosphoglycerate kinase 1 | -0.0636867 |
| S100A6 | S100 calcium binding protein A6 | -0.0628905 |
| RPS6 | ribosomal protein S6 | -0.0612175 |
| TMC5 | transmembrane channel-like 5 | -0.0603428 |
| PTMA | prothymosin, alpha | -0.0585156 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0561481 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0486228 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0484468 |
| H1-0 | H1.0 linker histone | -0.0479522 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0469331 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0450238 |
| FTL | ferritin, light polypeptide | -0.044279 |
| RNF213 | ring finger protein 213 | -0.0434573 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.040083 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0379756 |
| WDR45B | WD repeat domain 45B | -0.0379562 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0377401 |
| EPCAM | epithelial cell adhesion molecule | -0.0376337 |
| HLA-A | major histocompatibility complex, class I, A | -0.0371788 |
| RPS19 | ribosomal protein S19 | -0.0370478 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0370239 |
| S100A9 | S100 calcium binding protein A9 | -0.0367127 |
| CALR | calreticulin | -0.0360317 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0355901 |
| FGFR2 | fibroblast growth factor receptor 2 | -0.0355254 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0345269 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0339111 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.033023 |
| RPL35A | ribosomal protein L35a | -0.0326237 |
| TMSB4X | thymosin beta 4, X-linked | -0.0325969 |
| RPS3 | ribosomal protein S3 | -0.0312189 |
| ZNF292 | zinc finger protein 292 | -0.0292266 |
| SP100 | SP100 nuclear antigen | -0.0290954 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0290132 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0287449 |
| RPLP1 | ribosomal protein, large, P1 | -0.0279886 |
| ACACA | acetyl-CoA carboxylase alpha | -0.027615 |
| RPL23 | ribosomal protein L23 | -0.0273188 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0271087 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.02704 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0263486 |
| FAM13A | family with sequence similarity 13, member A | -0.0262571 |
| ANLN | anillin, actin binding protein | -0.0261343 |
| MYO6 | myosin VI | -0.0261318 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0257378 |
| S100A11 | S100 calcium binding protein A11 | -0.0257142 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0254797 |
| PLSCR1 | phospholipid scramblase 1 | -0.0254345 |
| ITGB4 | integrin, beta 4 | -0.0251946 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.0242843 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0237154 |
| NDRG1 | N-myc downstream regulated 1 | -0.0236393 |
| LYZ | lysozyme | -0.0234148 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.02295 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0228855 |
| RLF | rearranged L-myc fusion | -0.0219551 |
| KRT18 | keratin 18, type I | -0.0219041 |
| TRIM56 | tripartite motif containing 56 | -0.0219023 |
| NEK6 | NIMA-related kinase 6 | -0.0217726 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | -0.0216854 |
| RPS27 | ribosomal protein S27 | -0.0215758 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0215389 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0214041 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0211034 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0210639 |
| APOL1 | apolipoprotein L, 1 | -0.021041 |
| RPL36A | ribosomal protein L36a | -0.0210262 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0207646 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0207178 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0205648 |
| HLA-B | major histocompatibility complex, class I, B | -0.0205551 |
| ENO1 | enolase 1, (alpha) | -0.0204156 |
| RPS8 | ribosomal protein S8 | -0.0201735 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0198735 |
| S100P | S100 calcium binding protein P | -0.0198418 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0198167 |
| RPL30 | ribosomal protein L30 | -0.0197839 |
| MX1 | MX dynamin-like GTPase 1 | -0.0196806 |
| RRBP1 | ribosome binding protein 1 | -0.0193748 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0191467 |
| KRT19 | keratin 19, type I | -0.0190733 |
| XPO1 | exportin 1 | -0.0189362 |
| PFN1 | profilin 1 | -0.0188819 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0187786 |
| PKM | pyruvate kinase, muscle | -0.0187613 |
| RPL35 | ribosomal protein L35 | -0.0185864 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0183324 |
| AGR2 | anterior gradient 2 | -0.0183139 |
| RPL12 | ribosomal protein L12 | -0.0182559 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0181526 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0180955 |
| HMGB1 | high mobility group box 1 | -0.0179159 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0178283 |
| HLA-E | major histocompatibility complex, class I, E | -0.0178147 |
