| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Tofacitinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | 0.0958304 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.070452 |
| FAT1 | FAT atypical cadherin 1 | 0.0567559 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0561483 |
| RPLP0 | ribosomal protein, large, P0 | 0.0488816 |
| TPI1 | triosephosphate isomerase 1 | 0.0484932 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0482067 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0477893 |
| LAMA4 | laminin, alpha 4 | 0.0463414 |
| LDHA | lactate dehydrogenase A | 0.0451717 |
| LMO7 | LIM domain 7 | 0.0424307 |
| KRT19 | keratin 19, type I | 0.042059 |
| GSTP1 | glutathione S-transferase pi 1 | 0.0401984 |
| KRT18 | keratin 18, type I | 0.0395663 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0355292 |
| PFN1 | profilin 1 | 0.03535 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0341982 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0305437 |
| VCL | vinculin | 0.0303775 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0296924 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0288032 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0282648 |
| MLEC | malectin | 0.0281341 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0277712 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0268124 |
| RPL18 | ribosomal protein L18 | 0.0266168 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0261457 |
| ASPH | aspartate beta-hydroxylase | 0.0261299 |
| CLDN4 | claudin 4 | 0.0257701 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0257278 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0253984 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0251347 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0249555 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0237703 |
| CBX3 | chromobox homolog 3 | 0.0232985 |
| RPS19 | ribosomal protein S19 | 0.0225155 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0223744 |
| MT1X | metallothionein 1X | 0.022263 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0222312 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0220632 |
| PRSS3 | protease, serine, 3 | 0.0220411 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0217564 |
| HMGA1 | high mobility group AT-hook 1 | 0.0216656 |
| POTEF | POTE ankyrin domain family, member F | 0.0216025 |
| SVIL | supervillin | 0.0212775 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.021221 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 0.0212195 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0210555 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0204653 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0204653 |
| ANXA3 | annexin A3 | 0.0202744 |
| CALB1 | calbindin 1, 28kDa | 0.0200175 |
| PKP2 | plakophilin 2 | 0.0195137 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0192386 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0192098 |
| FTL | ferritin, light polypeptide | 0.018679 |
| FAM120A | family with sequence similarity 120A | 0.0184626 |
| CAB39 | calcium binding protein 39 | 0.0179515 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.0179468 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0174336 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0173513 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | 0.0172342 |
| NOSTRIN | nitric oxide synthase trafficking | 0.0171901 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0168327 |
| TAGLN2 | transgelin 2 | 0.0167819 |
| TNS4 | tensin 4 | 0.0166172 |
| KLF6 | Kruppel-like factor 6 | 0.0165834 |
| MT1E | metallothionein 1E | 0.0164012 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | 0.016357 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0162396 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0160843 |
| RCOR1 | REST corepressor 1 | 0.0159362 |
| EGFR | epidermal growth factor receptor | 0.0158224 |
| MED13 | mediator complex subunit 13 | 0.0158202 |
| NRXN3 | neurexin 3 | 0.0154419 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0153388 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0153009 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0152758 |
| ETV6 | ets variant 6 | 0.0152107 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0150862 |
| ABHD2 | abhydrolase domain containing 2 | 0.0150295 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0148681 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0148286 |
| CENPF | centromere protein F, 350/400kDa | 0.0148203 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 0.0147375 |
| GREB1L | growth regulation by estrogen in breast cancer-like | 0.0146894 |
| IGFL2 | IGF-like family member 2 | 0.0146339 |
| ANXA11 | annexin A11 | 0.0146214 |
| FERMT1 | fermitin family member 1 | 0.0143613 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0143332 |
| ETNK1 | ethanolamine kinase 1 | 0.0143056 |
| CLTC | clathrin, heavy chain (Hc) | 0.0142644 |
| TUBA1B | tubulin, alpha 1b | 0.0142523 |
| CMPK1 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic | 0.0141653 |
| ITGB5 | integrin, beta 5 | 0.0140658 |
| JAK2 | Janus kinase 2 | 0.0139987 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0139725 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0138501 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0138115 |
| CLIC1 | chloride intracellular channel 1 | 0.0138016 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.175244 |
| RPS6 | ribosomal protein S6 | -0.0992383 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0925189 |
| AHNAK | AHNAK nucleoprotein | -0.0852529 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0826656 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.081906 |
| EZR | ezrin | -0.0808348 |
| RPS27A | ribosomal protein S27a | -0.0804512 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0803389 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0722343 |
| PIGR | polymeric immunoglobulin receptor | -0.0706922 |
| ONECUT3 | one cut homeobox 3 | -0.070564 |
| RPS29 | ribosomal protein S29 | -0.0648277 |
| RPS8 | ribosomal protein S8 | -0.0624006 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.062114 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0610564 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0599398 |
| EPCAM | epithelial cell adhesion molecule | -0.0548921 |
| KIF5B | kinesin family member 5B | -0.0490477 |
| UBC | ubiquitin C | -0.0488711 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0480013 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0477159 |
| ACTG1 | actin gamma 1 | -0.0476074 |
| RPLP2 | ribosomal protein, large, P2 | -0.0471794 |
| FAM13A | family with sequence similarity 13, member A | -0.0468581 |
| RPLP1 | ribosomal protein, large, P1 | -0.0458057 |
| TXNIP | thioredoxin interacting protein | -0.0455522 |
| RPL4 | ribosomal protein L4 | -0.0442357 |
| GOLGA4 | golgin A4 | -0.0440188 |
| CANX | calnexin | -0.0433157 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0417204 |
| B2M | beta-2-microglobulin | -0.0392264 |
| RPL34 | ribosomal protein L34 | -0.038898 |
| RPL7A | ribosomal protein L7a | -0.0384714 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0372512 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0371295 |
| RPS13 | ribosomal protein S13 | -0.0363393 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0360521 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0352982 |
| GLG1 | golgi glycoprotein 1 | -0.0348011 |
| APP | amyloid beta (A4) precursor protein | -0.0344742 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0341921 |
| IER3 | immediate early response 3 | -0.0339103 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0337904 |
| RPL38 | ribosomal protein L38 | -0.033675 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0332409 |
| ACTN4 | actinin, alpha 4 | -0.033191 |
| LMNA | lamin A/C | -0.032859 |
| RPL31 | ribosomal protein L31 | -0.0328465 |
| RPL35A | ribosomal protein L35a | -0.0327837 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0322528 |
| ANXA2 | annexin A2 | -0.0322125 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0317155 |
| TMSB4X | thymosin beta 4, X-linked | -0.031371 |
| RPL13A | ribosomal protein L13a | -0.0307907 |
| NFIA | nuclear factor I/A | -0.0307872 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0305063 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0303199 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0302036 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0295955 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.029488 |
| TC2N | tandem C2 domains, nuclear | -0.0294862 |
| USP34 | ubiquitin specific peptidase 34 | -0.0294512 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.029261 |
| RPS25 | ribosomal protein S25 | -0.0291885 |
| OGA | O-GlcNAcase | -0.029067 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0290629 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0287696 |
| AGR2 | anterior gradient 2 | -0.0287197 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0284828 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0284297 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0283784 |
| FRMD5 | FERM domain containing 5 | -0.028366 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0281111 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0280086 |
| TFF1 | trefoil factor 1 | -0.0274469 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0274116 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0272755 |
| CCNY | cyclin Y | -0.0272351 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.0271666 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0267621 |
| RPS11 | ribosomal protein S11 | -0.0265999 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0264972 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0264914 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0263161 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0261613 |
| TMC5 | transmembrane channel-like 5 | -0.0261076 |
| CMIP | c-Maf inducing protein | -0.0260368 |
| FDPS | farnesyl diphosphate synthase | -0.0259687 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.0258184 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.025424 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0253383 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0252249 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0250926 |
| RPL5 | ribosomal protein L5 | -0.0250909 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0248729 |
| FLNB | filamin B, beta | -0.0247925 |
| BPTF | bromodomain PHD finger transcription factor | -0.0245587 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0245084 |
| MAP4 | microtubule-associated protein 4 | -0.0240321 |
