| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.16947 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0901197 |
| CAPRIN2 | caprin family member 2 | 0.0762037 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0687304 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0601813 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0601421 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0544554 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.045985 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0421453 |
| CADM2 | cell adhesion molecule 2 | 0.0415266 |
| RUNX1 | runt-related transcription factor 1 | 0.0409302 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0383656 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0383044 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0365049 |
| EREG | epiregulin | 0.0362762 |
| EMP1 | epithelial membrane protein 1 | 0.035264 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0345841 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0340858 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0302026 |
| TXNRD1 | thioredoxin reductase 1 | 0.0301833 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0295406 |
| PTMA | prothymosin, alpha | 0.0294328 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0288457 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0287892 |
| HDLBP | high density lipoprotein binding protein | 0.0272651 |
| ANXA1 | annexin A1 | 0.0269736 |
| NBEA | neurobeachin | 0.0267735 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0264062 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0253063 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.025303 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0251578 |
| VEGFC | vascular endothelial growth factor C | 0.0247364 |
| ASPH | aspartate beta-hydroxylase | 0.0243124 |
| HOMER1 | homer scaffolding protein 1 | 0.0236974 |
| PLK2 | polo-like kinase 2 | 0.0236409 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0232416 |
| CLTC | clathrin, heavy chain (Hc) | 0.0230915 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.023002 |
| SRGN | serglycin | 0.0225811 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0219845 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0218184 |
| ANO6 | anoctamin 6 | 0.0212233 |
| SFTPA2 | surfactant protein A2 | 0.0212083 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | 0.0211688 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0209408 |
| AHNAK | AHNAK nucleoprotein | 0.0207346 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.0205126 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0202144 |
| ANXA2 | annexin A2 | 0.0201326 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0200124 |
| TUBB6 | tubulin, beta 6 class V | 0.0193988 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0190111 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.018049 |
| FBXO11 | F-box protein 11 | 0.0179309 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0177912 |
| AREG | amphiregulin | 0.0177698 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0174248 |
| COG5 | component of oligomeric golgi complex 5 | 0.0173961 |
| NBEAL1 | neurobeachin-like 1 | 0.0173626 |
| ANKRD50 | ankyrin repeat domain 50 | 0.017114 |
| GOLGB1 | golgin B1 | 0.0170579 |
| RASAL2 | RAS protein activator like 2 | 0.0168661 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0168296 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0167561 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0167174 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0166703 |
| ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit | 0.0165444 |
| PYGB | phosphorylase, glycogen; brain | 0.0164195 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0161767 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0160338 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0158366 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.0155141 |
| UPP1 | uridine phosphorylase 1 | 0.0154158 |
| MYO9A | myosin IXA | 0.0154042 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0153973 |
| USP12 | ubiquitin specific peptidase 12 | 0.0153542 |
| RCAN1 | regulator of calcineurin 1 | 0.0153178 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0152536 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.015046 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.0150043 |
| UTRN | utrophin | 0.0149955 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0149808 |
| SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | 0.0149644 |
| AHI1 | Abelson helper integration site 1 | 0.0149058 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0148103 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0147831 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.0147436 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0145499 |
| ADIPOR2 | adiponectin receptor 2 | 0.0143897 |
| BBX | bobby sox homolog (Drosophila) | 0.0142339 |
| MYO10 | myosin X | 0.0142264 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | 0.0141612 |
| NBAS | neuroblastoma amplified sequence | 0.0141439 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0141171 |
| TUBA1B | tubulin, alpha 1b | 0.0141032 |
| FAM168A | family with sequence similarity 168, member A | 0.0140363 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0139739 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.013928 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.0139173 |
| SPPL3 | signal peptide peptidase like 3 | 0.0138645 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TP63 | tumor protein p63 | -0.191345 |
| CD44 | CD44 molecule (Indian blood group) | -0.127077 |
| RNF213 | ring finger protein 213 | -0.113678 |
| RAD51B | RAD51 paralog B | -0.110109 |
| RIGI | RNA sensor RIG-I | -0.105096 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0976636 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0874421 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0867767 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0814402 |
| TMSB4X | thymosin beta 4, X-linked | -0.0813823 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0787373 |
| TMSB10 | thymosin beta 10 | -0.0785053 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0782172 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0747213 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.073922 |
| SP100 | SP100 nuclear antigen | -0.0694921 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0685743 |
| RPL23 | ribosomal protein L23 | -0.0678616 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0676813 |
| TNS3 | tensin 3 | -0.0628002 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0621796 |
| PLSCR1 | phospholipid scramblase 1 | -0.0619974 |
| DNER | delta/notch-like EGF repeat containing | -0.0569561 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0520632 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0516143 |
| ECE1 | endothelin converting enzyme 1 | -0.0515625 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0494827 |
| RPS12 | ribosomal protein S12 | -0.0479275 |
| RPL26 | ribosomal protein L26 | -0.0472272 |
| PYGL | phosphorylase, glycogen, liver | -0.046647 |
| DPH6 | diphthamine biosynthesis 6 | -0.0444499 |
| SRPK2 | SRSF protein kinase 2 | -0.044227 |
| RPL35A | ribosomal protein L35a | -0.0432178 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.042806 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0426991 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0420243 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0419452 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0417843 |
| CMIP | c-Maf inducing protein | -0.0411982 |
| COL5A2 | collagen, type V, alpha 2 | -0.0408504 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0406697 |
| TGM2 | transglutaminase 2 | -0.0394791 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | -0.0394224 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0390255 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0388238 |
| TPRG1 | tumor protein p63 regulated 1 | -0.0388022 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0382771 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0374617 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0373865 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0373389 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0367503 |
| RPS19 | ribosomal protein S19 | -0.0366317 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0366138 |
| LRRC49 | leucine rich repeat containing 49 | -0.0365698 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0359319 |
| RPS6 | ribosomal protein S6 | -0.0356235 |
| MT1X | metallothionein 1X | -0.0355671 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0350868 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | -0.0347771 |
| EXOC4 | exocyst complex component 4 | -0.0339772 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0338662 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0333908 |
| PMP22 | peripheral myelin protein 22 | -0.0332434 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0330661 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | -0.0330399 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0325503 |
| NEK10 | NIMA-related kinase 10 | -0.031889 |
| TRIM56 | tripartite motif containing 56 | -0.031726 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.0314905 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.031422 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.031112 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0309727 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0309308 |
| FMNL2 | formin-like 2 | -0.0306936 |
| RPL12 | ribosomal protein L12 | -0.0306012 |
| ADAR | adenosine deaminase, RNA-specific | -0.0300846 |
| LOXL2 | lysyl oxidase-like 2 | -0.0300354 |
| BMERB1 | bMERB domain containing 1 | -0.0295305 |
| NF1 | neurofibromin 1 | -0.0292087 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0290699 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0289329 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0288926 |
| AMBRA1 | autophagy/beclin-1 regulator 1 | -0.0288621 |
| RPS27A | ribosomal protein S27a | -0.0285406 |
| ANKFY1 | ankyrin repeat and FYVE domain containing 1 | -0.028491 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0284363 |
| RPL36A | ribosomal protein L36a | -0.0276841 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0276059 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0275731 |
| FOXN3 | forkhead box N3 | -0.0275603 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0275117 |
| SDC4 | syndecan 4 | -0.0274107 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0271456 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0270654 |
| SBF2 | SET binding factor 2 | -0.0266564 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0264044 |
| SMAD3 | SMAD family member 3 | -0.0263899 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0262021 |
| ZNF217 | zinc finger protein 217 | -0.0262008 |
| PARD3 | par-3 family cell polarity regulator | -0.0261385 |
