| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.100045 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0811636 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0765011 |
| TOP1 | topoisomerase (DNA) I | 0.0752191 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0736505 |
| TXNRD1 | thioredoxin reductase 1 | 0.0657841 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0622765 |
| MYOF | myoferlin | 0.0583795 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0513549 |
| GRAMD1B | GRAM domain containing 1B | 0.0485802 |
| PCBP2 | poly(rC) binding protein 2 | 0.0445426 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0427381 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0422738 |
| MKI67 | marker of proliferation Ki-67 | 0.0387742 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0370145 |
| TES | testin LIM domain protein | 0.0362435 |
| LDHA | lactate dehydrogenase A | 0.0345412 |
| LAMA4 | laminin, alpha 4 | 0.033642 |
| CPE | carboxypeptidase E | 0.0331994 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.032885 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0325596 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.031609 |
| VCL | vinculin | 0.0313008 |
| LMO7 | LIM domain 7 | 0.0311384 |
| HELZ | helicase with zinc finger | 0.0310882 |
| TSC22D2 | TSC22 domain family, member 2 | 0.030677 |
| RUNX1 | runt-related transcription factor 1 | 0.0304417 |
| RPLP0 | ribosomal protein, large, P0 | 0.0302915 |
| RPS12 | ribosomal protein S12 | 0.0297656 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0295176 |
| TPI1 | triosephosphate isomerase 1 | 0.0289894 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0287896 |
| RTN4 | reticulon 4 | 0.0286128 |
| FAT1 | FAT atypical cadherin 1 | 0.0283747 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0282226 |
| VMP1 | vacuole membrane protein 1 | 0.0281067 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0279001 |
| RPS3 | ribosomal protein S3 | 0.0264076 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0260806 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0256156 |
| PTEN | phosphatase and tensin homolog | 0.0244556 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0243246 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0242151 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0236984 |
| SPAG9 | sperm associated antigen 9 | 0.023529 |
| RNF145 | ring finger protein 145 | 0.0229467 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0228625 |
| RPS4X | ribosomal protein S4, X-linked | 0.0228612 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0224876 |
| CCNL1 | cyclin L1 | 0.0222243 |
| ECT2 | epithelial cell transforming 2 | 0.0219998 |
| NPTN | neuroplastin | 0.0217814 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0209903 |
| CENPF | centromere protein F, 350/400kDa | 0.0209864 |
| NBEAL1 | neurobeachin-like 1 | 0.0207752 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0206792 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0206029 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0205464 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0203457 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0199413 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0197455 |
| PGK1 | phosphoglycerate kinase 1 | 0.0196475 |
| PRELID2 | PRELI domain containing 2 | 0.019513 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0194826 |
| ATAD2B | ATPase family, AAA domain containing 2B | 0.0193691 |
| SON | SON DNA binding protein | 0.0192651 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0191445 |
| KIAA1328 | KIAA1328 | 0.0189844 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.018918 |
| YBX1 | Y box binding protein 1 | 0.0188903 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.018795 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0185147 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0182849 |
| YTHDC1 | YTH domain containing 1 | 0.0182832 |
| SCEL | sciellin | 0.0181707 |
| GSTP1 | glutathione S-transferase pi 1 | 0.01816 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0180448 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.017909 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0178469 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0178427 |
| PLS3 | plastin 3 | 0.017711 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0176835 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0176686 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0176244 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0176177 |
| IRS2 | insulin receptor substrate 2 | 0.017501 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0173504 |
| TFG | TRK-fused gene | 0.0173411 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0172192 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0171715 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0171292 |
| TMEM165 | transmembrane protein 165 | 0.0171004 |
| VEGFC | vascular endothelial growth factor C | 0.0169427 |
| LDHB | lactate dehydrogenase B | 0.0168697 |
| AHR | aryl hydrocarbon receptor | 0.0166352 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.016546 |
| RBM39 | RNA binding motif protein 39 | 0.0165183 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0165155 |
| BMP6 | bone morphogenetic protein 6 | 0.0164498 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0162326 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.248356 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.193499 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.124952 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.111442 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.103143 |
| EFNA5 | ephrin-A5 | -0.0913413 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0896348 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0895827 |
| ACTG1 | actin gamma 1 | -0.0882029 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0870963 |
| AHNAK | AHNAK nucleoprotein | -0.0869448 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0816922 |
| RNF213 | ring finger protein 213 | -0.079687 |
| LAMC2 | laminin, gamma 2 | -0.0775967 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0734156 |
| SP100 | SP100 nuclear antigen | -0.0712473 |
| TMSB10 | thymosin beta 10 | -0.0702213 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0693368 |
| B2M | beta-2-microglobulin | -0.0690531 |
| TRIM56 | tripartite motif containing 56 | -0.0679512 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0674418 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0669421 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0647072 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0637856 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0601787 |
| S100A10 | S100 calcium binding protein A10 | -0.0584688 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0578193 |
| HLA-B | major histocompatibility complex, class I, B | -0.0576361 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0564157 |
| PTMA | prothymosin, alpha | -0.0528895 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.05176 |
| STC1 | stanniocalcin 1 | -0.0516069 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0499668 |
| CST3 | cystatin C | -0.0476479 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0463926 |
| OSMR | oncostatin M receptor | -0.0463864 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0457542 |
| KRT18 | keratin 18, type I | -0.044862 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0436694 |
| ANXA2 | annexin A2 | -0.0434649 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0433998 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0418248 |
| H1-0 | H1.0 linker histone | -0.0414101 |
| RPL34 | ribosomal protein L34 | -0.0412562 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.039826 |
| MX1 | MX dynamin-like GTPase 1 | -0.0385964 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0373504 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0372192 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0353629 |
| CUX1 | cut-like homeobox 1 | -0.0353331 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.035106 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0345868 |
| KRT7 | keratin 7, type II | -0.0345495 |
| TPM4 | tropomyosin 4 | -0.0340956 |
| SDC4 | syndecan 4 | -0.0337771 |
| ASPH | aspartate beta-hydroxylase | -0.0332268 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.032757 |
| CCND1 | cyclin D1 | -0.0315068 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0314514 |
| HDLBP | high density lipoprotein binding protein | -0.0314242 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0306105 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0305955 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0305362 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0302708 |
| PKM | pyruvate kinase, muscle | -0.0302033 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0300325 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0300012 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0297461 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0295937 |
| MYO1D | myosin ID | -0.0294909 |
| RIGI | RNA sensor RIG-I | -0.0292877 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0292266 |
| PMP22 | peripheral myelin protein 22 | -0.0291699 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0291086 |
| APP | amyloid beta (A4) precursor protein | -0.0287394 |
| IFI44L | interferon-induced protein 44-like | -0.0285523 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.028502 |
| ADAR | adenosine deaminase, RNA-specific | -0.0283917 |
| PLSCR1 | phospholipid scramblase 1 | -0.0279186 |
| DSG2 | desmoglein 2 | -0.0279102 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0278456 |
| INTS6 | integrator complex subunit 6 | -0.0276618 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0274461 |
| EHBP1 | EH domain binding protein 1 | -0.0270362 |
| RPL35A | ribosomal protein L35a | -0.0269693 |
| EGR1 | early growth response 1 | -0.0268275 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0267509 |
| CTSL | cathepsin L | -0.0265017 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0263212 |
| NDRG1 | N-myc downstream regulated 1 | -0.0255831 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0254524 |
| CP | ceruloplasmin (ferroxidase) | -0.025137 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0251221 |
| RPL31 | ribosomal protein L31 | -0.0249304 |
| CDR2 | cerebellar degeneration-related protein 2, 62kDa | -0.0247514 |
| IER3 | immediate early response 3 | -0.0243816 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0243267 |
| FRY | furry homolog (Drosophila) | -0.0242749 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0241084 |
| FBXO11 | F-box protein 11 | -0.0239725 |
