Tofacitinib_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tofacitinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tofacitinib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.164056
HMGA2 high mobility group AT-hook 2 0.137838
PCBP2 poly(rC) binding protein 2 0.129821
GRB10 growth factor receptor-bound protein 10 0.104246
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.100328
PSD3 pleckstrin and Sec7 domain containing 3 0.0997765
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0882153
FN1 fibronectin 1 0.0881856
SYT1 synaptotagmin I 0.0850161
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0841623
CDH13 cadherin 13 0.0838604
SDK1 sidekick cell adhesion molecule 1 0.078137
P4HB prolyl 4-hydroxylase, beta polypeptide 0.073751
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0736323
PDE4D phosphodiesterase 4D, cAMP-specific 0.0711581
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.069997
NDRG1 N-myc downstream regulated 1 0.066033
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0650983
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0647246
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0626251
FAM13A family with sequence similarity 13, member A 0.0617673
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0602558
IGFBP3 insulin-like growth factor binding protein 3 0.0587703
MAML3 mastermind-like 3 (Drosophila) 0.0584086
AKAP12 A kinase (PRKA) anchor protein 12 0.0577796
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0553973
PRKCA protein kinase C, alpha 0.0545672
FTL ferritin, light polypeptide 0.0512887
PTMA prothymosin, alpha 0.0489225
PRELID2 PRELI domain containing 2 0.0483913
PABPC1 poly(A) binding protein, cytoplasmic 1 0.047624
PDLIM5 PDZ and LIM domain 5 0.0475905
KTN1 kinectin 1 (kinesin receptor) 0.047268
KDM2A lysine (K)-specific demethylase 2A 0.0471703
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0471579
STC1 stanniocalcin 1 0.0469201
DLG1 discs, large homolog 1 (Drosophila) 0.0468477
ATXN1 ataxin 1 0.0460712
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0455642
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0452013
ANTXR2 anthrax toxin receptor 2 0.0444581
INTS6 integrator complex subunit 6 0.0441657
ZSWIM6 zinc finger, SWIM-type containing 6 0.0439885
DDIT3 DNA-damage-inducible transcript 3 0.0438588
MEF2A myocyte enhancer factor 2A 0.0434216
GREB1L growth regulation by estrogen in breast cancer-like 0.0434057
FBN1 fibrillin 1 0.0433127
PIAS2 protein inhibitor of activated STAT, 2 0.0429992
MT2A metallothionein 2A 0.0424272
ARHGAP32 Rho GTPase activating protein 32 0.0412682
GPC6 glypican 6 0.0412117
APLP2 amyloid beta (A4) precursor-like protein 2 0.0412113
AKAP13 A kinase (PRKA) anchor protein 13 0.040233
RIOK3 RIO kinase 3 0.040042
WLS wntless Wnt ligand secretion mediator 0.0400359
PLIN2 perilipin 2 0.039827
TTC3 tetratricopeptide repeat domain 3 0.0398252
CA12 carbonic anhydrase XII 0.0397107
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0392098
DST dystonin 0.0383939
TMSB10 thymosin beta 10 0.0381627
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0381077
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0380807
MACF1 microtubule-actin crosslinking factor 1 0.0374745
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0368869
ESYT2 extended synaptotagmin-like protein 2 0.0367524
ANXA1 annexin A1 0.0365891
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0363191
AADAC arylacetamide deacetylase 0.035598
ZNF292 zinc finger protein 292 0.0354666
MSRB3 methionine sulfoxide reductase B3 0.0351503
EPS8 epidermal growth factor receptor pathway substrate 8 0.0351332
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0350072
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0345446
MAML2 mastermind-like 2 (Drosophila) 0.0342948
USP34 ubiquitin specific peptidase 34 0.0339062
ZNF638 zinc finger protein 638 0.0332826
NHSL1 NHS-like 1 0.0330755
KMT2C lysine (K)-specific methyltransferase 2C 0.0328759
ZCCHC7 zinc finger, CCHC domain containing 7 0.0322999
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.032296
FMNL2 formin-like 2 0.0321747
MYADM myeloid-associated differentiation marker 0.0319963
ASPH aspartate beta-hydroxylase 0.0318157
PKM pyruvate kinase, muscle 0.0316009
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.031444
RAI1 retinoic acid induced 1 0.0313779
UBA6 ubiquitin-like modifier activating enzyme 6 0.0310219
GOLGA4 golgin A4 0.0310019
RCOR1 REST corepressor 1 0.0308528
TAS2R14 taste receptor, type 2, member 14 0.0306029
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0305563
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0305516
B2M beta-2-microglobulin 0.0304757
VIM vimentin 0.0303555
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0303345
LIMCH1 LIM and calponin homology domains 1 0.0302861
JARID2 jumonji, AT rich interactive domain 2 0.0302815
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0302245
CXCL8 chemokine (C-X-C motif) ligand 8 0.0297986

decreased expression

Symbol Name Standardized Value
CD44 CD44 molecule (Indian blood group) -0.173821
OSMR oncostatin M receptor -0.155073
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.095306
ZEB2 zinc finger E-box binding homeobox 2 -0.0808302
FNDC3B fibronectin type III domain containing 3B -0.0775816
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0738273
NPC1 Niemann-Pick disease, type C1 -0.0697475
RAB27B RAB27B, member RAS oncogene family -0.0626161
KYNU kynureninase -0.0623141
GLCCI1 glucocorticoid induced 1 -0.0600025
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0553287
AOPEP aminopeptidase O (putative) -0.0553122
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0544742
ETV6 ets variant 6 -0.0529494
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0523771
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0511898
NCOA7 nuclear receptor coactivator 7 -0.050983
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0505066
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0481124
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0469349
PID1 phosphotyrosine interaction domain containing 1 -0.0452734
ARHGAP5 Rho GTPase activating protein 5 -0.044548
NAMPT nicotinamide phosphoribosyltransferase -0.0436105
HEG1 heart development protein with EGF-like domains 1 -0.0430591
ZC3H12C zinc finger CCCH-type containing 12C -0.042418
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0419688
RBM39 RNA binding motif protein 39 -0.0407083
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0402746
NRP1 neuropilin 1 -0.0387629
BMAL2 basic helix-loop-helix ARNT like 2 -0.0361999
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0360304
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0358541
IFI44L interferon-induced protein 44-like -0.0356677
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0352315
FAM20C family with sequence similarity 20, member C -0.0348882
RNF24 ring finger protein 24 -0.0340699
CAB39 calcium binding protein 39 -0.0334676
CDK17 cyclin-dependent kinase 17 -0.0322652
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0321321
MX2 MX dynamin-like GTPase 2 -0.0319552
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0317408
RPL4 ribosomal protein L4 -0.0315355
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0314128
DSCAM Down syndrome cell adhesion molecule -0.0313442
COL12A1 collagen, type XII, alpha 1 -0.0310936
KSR1 kinase suppressor of ras 1 -0.0310914
FRMD4A FERM domain containing 4A -0.0300485
PLSCR1 phospholipid scramblase 1 -0.0293809
RIGI RNA sensor RIG-I -0.0285809
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.028128
IL1R1 interleukin 1 receptor, type I -0.0271225
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0270889
BACE2 beta-site APP-cleaving enzyme 2 -0.026848
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0268173
NRG1 neuregulin 1 -0.0267546
LUZP1 leucine zipper protein 1 -0.0263527
BASP1 brain abundant, membrane attached signal protein 1 -0.0263304
SOD2 superoxide dismutase 2, mitochondrial -0.0260935
MX1 MX dynamin-like GTPase 1 -0.0257556
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0255266
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0254905
DAAM1 dishevelled associated activator of morphogenesis 1 -0.0251214
TNNC1 troponin C type 1 (slow) -0.0241389
AGFG1 ArfGAP with FG repeats 1 -0.0239225
IFI44 interferon-induced protein 44 -0.0238402
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.023506
ELL2 elongation factor, RNA polymerase II, 2 -0.0231876
PCNX1 pecanex 1 -0.0231613
GRAMD1B GRAM domain containing 1B -0.0229145
HAS2 hyaluronan synthase 2 -0.0228196
CDCP1 CUB domain containing protein 1 -0.0227148
MEIS1 Meis homeobox 1 -0.0226313
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0222929
AHNAK AHNAK nucleoprotein -0.022183
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.022124
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0221023
DOCK4 dedicator of cytokinesis 4 -0.0216063
KLF6 Kruppel-like factor 6 -0.021385
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.020971
MAPK8 mitogen-activated protein kinase 8 -0.0207997
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0206011
SP100 SP100 nuclear antigen -0.0204599
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0203397
LPAR1 lysophosphatidic acid receptor 1 -0.0197557
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0195957
SOS2 son of sevenless homolog 2 (Drosophila) -0.0195908
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0195379
PTBP3 polypyrimidine tract binding protein 3 -0.0190784
CEP95 centrosomal protein 95kDa -0.0188439
NECTIN2 nectin cell adhesion molecule 2 -0.0186057
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0185951
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0182956
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0182385
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0178318
RNF149 ring finger protein 149 -0.0178168
EIF4H eukaryotic translation initiation factor 4H -0.0177283
FRMD5 FERM domain containing 5 -0.0176897
CCDC68 coiled-coil domain containing 68 -0.0175044
CYTH1 cytohesin 1 -0.0174787
SRPK1 SRSF protein kinase 1 -0.0174314