| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.1846 |
| MT2A | metallothionein 2A | 0.13583 |
| PM20D1 | peptidase M20 domain containing 1 | 0.129244 |
| FTL | ferritin, light polypeptide | 0.116648 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.107431 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0971232 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0757847 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0729166 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0625833 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0622839 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0615006 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0598609 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0536751 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.049874 |
| EGFR | epidermal growth factor receptor | 0.0480033 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0474519 |
| ATXN1 | ataxin 1 | 0.0471081 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0470398 |
| FMNL2 | formin-like 2 | 0.0468459 |
| POTEF | POTE ankyrin domain family, member F | 0.0460389 |
| KYNU | kynureninase | 0.0459843 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0437631 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0420388 |
| PFN1 | profilin 1 | 0.0407835 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0402482 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0393665 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0385932 |
| BRD2 | bromodomain containing 2 | 0.0381672 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0377218 |
| INTS6 | integrator complex subunit 6 | 0.0375095 |
| CMIP | c-Maf inducing protein | 0.036003 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0347053 |
| PRELID2 | PRELI domain containing 2 | 0.0343914 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0336317 |
| TPM1 | tropomyosin 1 (alpha) | 0.0331835 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0328055 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0323414 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0321412 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.031529 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0304475 |
| RAD51B | RAD51 paralog B | 0.0303232 |
| RCOR1 | REST corepressor 1 | 0.029782 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0294096 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0289435 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0288027 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0284333 |
| UTRN | utrophin | 0.0277245 |
| NBEAL1 | neurobeachin-like 1 | 0.0276975 |
| MYO1E | myosin IE | 0.0276378 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0274834 |
| DOCK5 | dedicator of cytokinesis 5 | 0.027142 |
| FAM107B | family with sequence similarity 107, member B | 0.0270804 |
| PCBP2 | poly(rC) binding protein 2 | 0.027032 |
| GLIS3 | GLIS family zinc finger 3 | 0.0270037 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0269849 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0268463 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0266472 |
| DST | dystonin | 0.0263068 |
| EHBP1 | EH domain binding protein 1 | 0.0261711 |
| WWOX | WW domain containing oxidoreductase | 0.02609 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0260271 |
| ZNF638 | zinc finger protein 638 | 0.0256864 |
| NF1 | neurofibromin 1 | 0.0254315 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0252653 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0243718 |
| MCL1 | myeloid cell leukemia 1 | 0.024325 |
| VMP1 | vacuole membrane protein 1 | 0.0240726 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0240382 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0235747 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0226524 |
| MSN | moesin | 0.0226122 |
| SMAD2 | SMAD family member 2 | 0.0225664 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0224211 |
| USP34 | ubiquitin specific peptidase 34 | 0.0223829 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | 0.0220771 |
| EXOC6B | exocyst complex component 6B | 0.0220075 |
| ATF6 | activating transcription factor 6 | 0.02191 |
| PRKD1 | protein kinase D1 | 0.0218874 |
| COPA | coatomer protein complex, subunit alpha | 0.0217923 |
| PRKCA | protein kinase C, alpha | 0.0217338 |
| VCL | vinculin | 0.0215601 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0214948 |
| RAB7A | RAB7A, member RAS oncogene family | 0.021363 |
| RRM2 | ribonucleotide reductase M2 | 0.0212092 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0211827 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0210132 |
| STC1 | stanniocalcin 1 | 0.0210041 |
| NLK | nemo-like kinase | 0.0209345 |
| NUMB | numb homolog (Drosophila) | 0.0207174 |
| PDE10A | phosphodiesterase 10A | 0.0205023 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0203712 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0201841 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0198219 |
| NEGR1 | neuronal growth regulator 1 | 0.019768 |
| FHIT | fragile histidine triad | 0.0197589 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0195831 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0194436 |
| MAP7 | microtubule-associated protein 7 | 0.0193884 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0193842 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0191084 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.184727 |
| GRAMD1B | GRAM domain containing 1B | -0.133403 |
| VIM | vimentin | -0.0798102 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0765249 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0731151 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0668421 |
| RPL4 | ribosomal protein L4 | -0.0658706 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0595492 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0592414 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0551372 |
| S100A6 | S100 calcium binding protein A6 | -0.0522065 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0490482 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0472788 |
| CAVIN1 | caveolae associated protein 1 | -0.0464585 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0454053 |
| APP | amyloid beta (A4) precursor protein | -0.0453889 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0421953 |
| HDAC9 | histone deacetylase 9 | -0.0415027 |
| PTMA | prothymosin, alpha | -0.0412887 |
| RPL23 | ribosomal protein L23 | -0.0411648 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0401324 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0394744 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0394039 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0369626 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0358746 |
| WDR43 | WD repeat domain 43 | -0.0342242 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0340864 |
| RTN4 | reticulon 4 | -0.0338635 |
| USP3 | ubiquitin specific peptidase 3 | -0.0335172 |
| YME1L1 | YME1-like 1 ATPase | -0.0334153 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0325523 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0325048 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0316096 |
| CANX | calnexin | -0.0314623 |
| TMSB10 | thymosin beta 10 | -0.0309698 |
| AHNAK | AHNAK nucleoprotein | -0.0309531 |
| RBM39 | RNA binding motif protein 39 | -0.0307583 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0305885 |
| ANXA2 | annexin A2 | -0.0301437 |
| RPL26 | ribosomal protein L26 | -0.0299128 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0294398 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0289635 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0288952 |
| ZNF292 | zinc finger protein 292 | -0.0279581 |
| MATR3 | matrin 3 | -0.0272496 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0272485 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0269629 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.026948 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0269062 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0268551 |
| OSMR | oncostatin M receptor | -0.0266415 |
| KIF5B | kinesin family member 5B | -0.026418 |
| RPS6 | ribosomal protein S6 | -0.0259715 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0258401 |
| CHN1 | chimerin 1 | -0.0255671 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0254802 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0254032 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0253057 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0252224 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0248883 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0245712 |
| TMEM123 | transmembrane protein 123 | -0.0240669 |
| YBX3 | Y box binding protein 3 | -0.0238829 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0237276 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0235403 |
| MYL12B | myosin, light chain 12B, regulatory | -0.023513 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0232247 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.022731 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0227284 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0226367 |
| LAMB1 | laminin, beta 1 | -0.0223492 |
| TPD52 | tumor protein D52 | -0.0223201 |
| GOLT1B | golgi transport 1B | -0.0222247 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0220542 |
| TPM3 | tropomyosin 3 | -0.0220318 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | -0.0215356 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0214977 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0206227 |
| BRIX1 | BRX1, biogenesis of ribosomes | -0.0205937 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0205373 |
| TPM4 | tropomyosin 4 | -0.0202262 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0201281 |
| BMPR1B | bone morphogenetic protein receptor, type IB | -0.0197863 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0197093 |
| ABI1 | abl-interactor 1 | -0.0196636 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0196535 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0196184 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0196172 |
| TLK1 | tousled-like kinase 1 | -0.0195778 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0195614 |
| IER3 | immediate early response 3 | -0.019529 |
| TCEA1 | transcription elongation factor A (SII), 1 | -0.0193639 |
| DARS1 | aspartyl-tRNA synthetase 1 | -0.0192901 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0191256 |
| THBS1 | thrombospondin 1 | -0.0190801 |
| KIFC3 | kinesin family member C3 | -0.0189794 |
| FOXN2 | forkhead box N2 | -0.0189455 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.018926 |
| PARK7 | parkinson protein 7 | -0.0187631 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0187292 |
