| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.105292 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0773466 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.074899 |
| IGF2 | insulin-like growth factor 2 | 0.0735424 |
| FN1 | fibronectin 1 | 0.0732535 |
| MYO1E | myosin IE | 0.0730863 |
| CALU | calumenin | 0.0705693 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0690015 |
| VIM | vimentin | 0.0677954 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0649728 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0632266 |
| NAV2 | neuron navigator 2 | 0.062833 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0617228 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0596673 |
| FLNB | filamin B, beta | 0.0554232 |
| ATXN1 | ataxin 1 | 0.0545164 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0541589 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0539637 |
| EHBP1 | EH domain binding protein 1 | 0.0519938 |
| CENPF | centromere protein F, 350/400kDa | 0.0500643 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0479934 |
| GOLGA4 | golgin A4 | 0.0470336 |
| SBF2 | SET binding factor 2 | 0.0466821 |
| AK1 | adenylate kinase 1 | 0.0458806 |
| MT2A | metallothionein 2A | 0.0442553 |
| JAK1 | Janus kinase 1 | 0.0439344 |
| NDRG1 | N-myc downstream regulated 1 | 0.0433741 |
| DSPP | dentin sialophosphoprotein | 0.0429392 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0429351 |
| PRELID2 | PRELI domain containing 2 | 0.0423791 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0420837 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0420568 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.041786 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0416198 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0410317 |
| MYOF | myoferlin | 0.0409904 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0406376 |
| OGA | O-GlcNAcase | 0.0396451 |
| MAP4 | microtubule-associated protein 4 | 0.0388315 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0387942 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.038269 |
| TBC1D5 | TBC1 domain family, member 5 | 0.038241 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0380099 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0378778 |
| COG5 | component of oligomeric golgi complex 5 | 0.0375414 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0371392 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0369629 |
| RPS19 | ribosomal protein S19 | 0.0363515 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0359559 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0358399 |
| HELZ | helicase with zinc finger | 0.0357214 |
| METTL15 | methyltransferase like 15 | 0.0355131 |
| GPC6 | glypican 6 | 0.0352161 |
| PRKCA | protein kinase C, alpha | 0.0350359 |
| ENO1 | enolase 1, (alpha) | 0.0348346 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0347817 |
| CEP95 | centrosomal protein 95kDa | 0.0346461 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0346349 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0345326 |
| ASPH | aspartate beta-hydroxylase | 0.0339265 |
| ITGA6 | integrin, alpha 6 | 0.0337702 |
| PCM1 | pericentriolar material 1 | 0.0336085 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0335525 |
| MORF4L2 | mortality factor 4 like 2 | 0.0332837 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0331518 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0330096 |
| RAD51B | RAD51 paralog B | 0.0330044 |
| FOXJ3 | forkhead box J3 | 0.032371 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0322913 |
| APP | amyloid beta (A4) precursor protein | 0.0320952 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0312079 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0311258 |
| RTN4 | reticulon 4 | 0.0310101 |
| UTRN | utrophin | 0.0307816 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0304715 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0302508 |
| MSI2 | musashi RNA-binding protein 2 | 0.0301086 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0298351 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0296165 |
| KIF13A | kinesin family member 13A | 0.0294682 |
| RNF24 | ring finger protein 24 | 0.0294424 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0292643 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0290526 |
| THOC2 | THO complex 2 | 0.0289647 |
| UBE3C | ubiquitin protein ligase E3C | 0.0283548 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0282453 |
| ATP11B | ATPase, class VI, type 11B | 0.0282297 |
| RPS12 | ribosomal protein S12 | 0.0279521 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0278798 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0271947 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0269038 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0267542 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.0266865 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0266783 |
| RPS3 | ribosomal protein S3 | 0.0263197 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0262607 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0262402 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0262371 |
| KDM5A | lysine (K)-specific demethylase 5A | 0.0260269 |
| NKTR | natural killer cell triggering receptor | 0.0259625 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.170544 |
| ATOSA | atos homolog A | -0.124396 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.118636 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.115135 |
| GRB10 | growth factor receptor-bound protein 10 | -0.111672 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0965116 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0881336 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0788445 |
| MUC16 | mucin 16, cell surface associated | -0.0762244 |
| SVIL | supervillin | -0.0682504 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0647994 |
| RBM47 | RNA binding motif protein 47 | -0.0646575 |
| HMGA2 | high mobility group AT-hook 2 | -0.0644022 |
| LAMB3 | laminin, beta 3 | -0.0634632 |
| TXNRD1 | thioredoxin reductase 1 | -0.0634118 |
| MCL1 | myeloid cell leukemia 1 | -0.0599111 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0569585 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0560611 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0554822 |
| PDE8A | phosphodiesterase 8A | -0.0538048 |
| ABHD17C | abhydrolase domain containing 17C | -0.0529153 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.05289 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0528888 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0518037 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0517788 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.051172 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0508277 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0502263 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0498675 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | -0.0494346 |
| SQSTM1 | sequestosome 1 | -0.048852 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0487878 |
| TXNIP | thioredoxin interacting protein | -0.0480615 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0480173 |
| SLC12A6 | solute carrier family 12 (potassium/chloride transporter), member 6 | -0.0478367 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0464164 |
| ERBIN | erbb2 interacting protein | -0.0453495 |
| FTL | ferritin, light polypeptide | -0.0453016 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0449411 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0447825 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0444453 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.044311 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0440079 |
| DUSP16 | dual specificity phosphatase 16 | -0.0438719 |
| EFNA5 | ephrin-A5 | -0.0437145 |
| EGR1 | early growth response 1 | -0.0424508 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0420797 |
| USP3 | ubiquitin specific peptidase 3 | -0.0418789 |
| CLDN7 | claudin 7 | -0.0417224 |
| FAM13A | family with sequence similarity 13, member A | -0.0415912 |
| ABI1 | abl-interactor 1 | -0.0415509 |
| OSMR | oncostatin M receptor | -0.0410755 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0403964 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0402579 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0401248 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0400566 |
| DTNA | dystrobrevin, alpha | -0.039809 |
| PARD3 | par-3 family cell polarity regulator | -0.0397406 |
| RAI14 | retinoic acid induced 14 | -0.0395862 |
| TNPO1 | transportin 1 | -0.0390969 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0389196 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0385473 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0382218 |
| FOXO1 | forkhead box O1 | -0.037333 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0372806 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0361873 |
| TULP4 | tubby like protein 4 | -0.0361235 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0349845 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.034733 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0344479 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0339846 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0335425 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0332343 |
| RNF213 | ring finger protein 213 | -0.0328329 |
| UBAP1 | ubiquitin associated protein 1 | -0.0327925 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0327341 |
| ANXA2 | annexin A2 | -0.0325542 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0325437 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0324381 |
| SPATA13 | spermatogenesis associated 13 | -0.032134 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0318947 |
| JMJD1C | jumonji domain containing 1C | -0.0318786 |
| SNX9 | sorting nexin 9 | -0.0317784 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0309262 |
| REPS1 | RALBP1 associated Eps domain containing 1 | -0.0306273 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0304216 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0303956 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.030318 |
| BCL2L1 | BCL2-like 1 | -0.0302679 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0301578 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0300826 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.02977 |
| CUX1 | cut-like homeobox 1 | -0.0294613 |
| TNRC18 | trinucleotide repeat containing 18 | -0.0293858 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0292066 |
| KRT17 | keratin 17, type I | -0.0291265 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0286513 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0286456 |
| TAOK1 | TAO kinase 1 | -0.0284869 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.0283368 |
