Tofacitinib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tofacitinib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tofacitinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0900626
TXNRD1 thioredoxin reductase 1 0.0840869
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.069494
YBX3 Y box binding protein 3 0.0684031
VCL vinculin 0.0666176
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.061176
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0588042
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0556833
PDE4D phosphodiesterase 4D, cAMP-specific 0.0540741
TPI1 triosephosphate isomerase 1 0.0530381
TFPI2 tissue factor pathway inhibitor 2 0.0522269
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.049602
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0489852
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0486677
TRIO trio Rho guanine nucleotide exchange factor 0.0473779
ELL2 elongation factor, RNA polymerase II, 2 0.0472924
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0449587
RAD51B RAD51 paralog B 0.0438799
DOCK5 dedicator of cytokinesis 5 0.0433956
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0398556
TAS2R14 taste receptor, type 2, member 14 0.0386607
ZFAND3 zinc finger, AN1-type domain 3 0.0382909
ZSWIM6 zinc finger, SWIM-type containing 6 0.0378354
PDLIM5 PDZ and LIM domain 5 0.0375736
VIM vimentin 0.0372631
SPRED2 sprouty-related, EVH1 domain containing 2 0.0369338
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0359261
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0354944
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0335034
EXOC4 exocyst complex component 4 0.0334713
WWOX WW domain containing oxidoreductase 0.0316291
CDK17 cyclin-dependent kinase 17 0.0306959
SMYD3 SET and MYND domain containing 3 0.0303385
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0299185
VMP1 vacuole membrane protein 1 0.0298625
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0292166
HOMER1 homer scaffolding protein 1 0.0290863
PUM1 pumilio RNA-binding family member 1 0.0288647
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0283135
SLC38A2 solute carrier family 38, member 2 0.0282892
PRELID2 PRELI domain containing 2 0.0279739
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0276708
CALD1 caldesmon 1 0.0268903
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0265802
BMP5 bone morphogenetic protein 5 0.0257345
MARCHF4 membrane associated ring-CH-type finger 4 0.0255735
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0255419
CLTC clathrin, heavy chain (Hc) 0.0255348
ANO6 anoctamin 6 0.0251725
RBM39 RNA binding motif protein 39 0.0250208
EXT1 exostosin glycosyltransferase 1 0.024992
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0241791
GRAMD1B GRAM domain containing 1B 0.0236932
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0236091
ADGRG6 adhesion G protein-coupled receptor G6 0.0235834
ZNF644 zinc finger protein 644 0.0235588
RIMS2 regulating synaptic membrane exocytosis 2 0.0233288
SMC4 structural maintenance of chromosomes 4 0.0230716
DIAPH3 diaphanous-related formin 3 0.0230683
COL4A5 collagen, type IV, alpha 5 0.0230251
JMJD1C jumonji domain containing 1C 0.0224342
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0222111
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0222086
WDPCP WD repeat containing planar cell polarity effector 0.022036
GPHN gephyrin 0.021327
EIF4A1 eukaryotic translation initiation factor 4A1 0.0213178
DSCAM Down syndrome cell adhesion molecule 0.0207612
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0205264
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0205248
GSK3B glycogen synthase kinase 3 beta 0.0204473
PLCB4 phospholipase C, beta 4 0.0203764
LOC102724023 ES1 protein homolog, mitochondrial 0.020294
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0201131
STC1 stanniocalcin 1 0.0200733
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0200622
NIPBL Nipped-B homolog (Drosophila) 0.0199351
SERBP1 SERPINE1 mRNA binding protein 1 0.019848
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0195599
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0195304
NF1 neurofibromin 1 0.0195114
ANKRD12 ankyrin repeat domain 12 0.0193507
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0190448
TM4SF1 transmembrane 4 L six family member 1 0.0189979
SDK1 sidekick cell adhesion molecule 1 0.0188952
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0188814
MYL12B myosin, light chain 12B, regulatory 0.0186335
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0186314
ANKRD36 ankyrin repeat domain 36 0.0185782
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0185387
CCDC91 coiled-coil domain containing 91 0.018532
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0183436
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0182032
DNAH14 dynein, axonemal, heavy chain 14 0.0180899
CBX3 chromobox homolog 3 0.0180245
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0180215
MYPN myopalladin 0.0179382
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0177042
SON SON DNA binding protein 0.0176543
ATXN1 ataxin 1 0.0173579
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0172178

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.211514
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.194679
RPS27 ribosomal protein S27 -0.0821541
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0780313
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0689326
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0677885
RPL35A ribosomal protein L35a -0.0677275
RPL37A ribosomal protein L37a -0.0646715
RPS8 ribosomal protein S8 -0.05637
HLA-B major histocompatibility complex, class I, B -0.0558952
IFI6 interferon, alpha-inducible protein 6 -0.0536858
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0529398
RPL37 ribosomal protein L37 -0.0524075
RPS19 ribosomal protein S19 -0.0485944
PTMA prothymosin, alpha -0.0482372
RPS29 ribosomal protein S29 -0.04631
RPS27A ribosomal protein S27a -0.0460135
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0455592
RPL31 ribosomal protein L31 -0.0451488
KTN1 kinectin 1 (kinesin receptor) -0.0451009
RPS3 ribosomal protein S3 -0.0448514
TPM2 tropomyosin 2 (beta) -0.042471
RPS6 ribosomal protein S6 -0.0418903
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0392566
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0372812
RPL26 ribosomal protein L26 -0.0369372
EEF2 eukaryotic translation elongation factor 2 -0.0359225
RPS10 ribosomal protein S10 -0.034653
RPL23 ribosomal protein L23 -0.0341893
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0335799
CANX calnexin -0.0334443
RPL8 ribosomal protein L8 -0.0329894
RPL36 ribosomal protein L36 -0.0328873
EEF1G eukaryotic translation elongation factor 1 gamma -0.0327689
PDIA3 protein disulfide isomerase family A, member 3 -0.0324878
RPL34 ribosomal protein L34 -0.0324047
ADAR adenosine deaminase, RNA-specific -0.031387
GOLGB1 golgin B1 -0.0309093
RPS25 ribosomal protein S25 -0.0307016
RPLP1 ribosomal protein, large, P1 -0.0299028
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0291659
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0286719
HM13 histocompatibility (minor) 13 -0.0282105
RPS23 ribosomal protein S23 -0.0279501
RPLP2 ribosomal protein, large, P2 -0.0277704
RPL38 ribosomal protein L38 -0.0276859
RPL13A ribosomal protein L13a -0.0273754
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0271869
RPS17 ribosomal protein S17 -0.0266914
PYGL phosphorylase, glycogen, liver -0.0256503
RSF1 remodeling and spacing factor 1 -0.025452
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0245157
RPS20 ribosomal protein S20 -0.0242667
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0242174
S100A10 S100 calcium binding protein A10 -0.0240438
GOLGA4 golgin A4 -0.0237333
RSL1D1 ribosomal L1 domain containing 1 -0.0234168
PDIA6 protein disulfide isomerase family A, member 6 -0.0233942
UBE2H ubiquitin-conjugating enzyme E2H -0.0233832
RPL5 ribosomal protein L5 -0.0229305
RPS15 ribosomal protein S15 -0.0224401
MAP4 microtubule-associated protein 4 -0.0224139
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0223958
ANKRD11 ankyrin repeat domain 11 -0.0223629
EIF1 eukaryotic translation initiation factor 1 -0.0218354
GNAS GNAS complex locus -0.0217883
AKAP9 A kinase (PRKA) anchor protein 9 -0.0215056
KDM2A lysine (K)-specific demethylase 2A -0.0215013
RPL32 ribosomal protein L32 -0.0212921
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0212787
RPL4 ribosomal protein L4 -0.0208729
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0206004
HYOU1 hypoxia up-regulated 1 -0.020591
RPS14 ribosomal protein S14 -0.0205148
TMEM165 transmembrane protein 165 -0.0203667
RPS13 ribosomal protein S13 -0.0203156
RAB6A RAB6A, member RAS oncogene family -0.020102
TAPBP TAP binding protein (tapasin) -0.020082
HLA-A major histocompatibility complex, class I, A -0.0200332
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0200241
RPL11 ribosomal protein L11 -0.0196252
RPL36A ribosomal protein L36a -0.0194934
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0194146
FTH1 ferritin, heavy polypeptide 1 -0.018713
SENP6 SUMO1/sentrin specific peptidase 6 -0.0186641
HDGF hepatoma-derived growth factor -0.0185769
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0185755
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0185215
AFF3 AF4/FMR2 family, member 3 -0.018466
RPL19 ribosomal protein L19 -0.0184409
CUX1 cut-like homeobox 1 -0.0182474
FLOT1 flotillin 1 -0.0176857
TCEAL4 transcription elongation factor A (SII)-like 4 -0.0175889
RACK1 receptor for activated C kinase 1 -0.0175119
TRIM56 tripartite motif containing 56 -0.0174881
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0171245
AHNAK AHNAK nucleoprotein -0.0169791
RPL9 ribosomal protein L9 -0.0168204
RPS21 ribosomal protein S21 -0.0168182
IGF2 insulin-like growth factor 2 -0.0167212