| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.122309 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.114961 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.102718 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0947438 |
| HMGA1 | high mobility group AT-hook 1 | 0.0925495 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0901692 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0813736 |
| NDRG1 | N-myc downstream regulated 1 | 0.075599 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0682182 |
| FHIT | fragile histidine triad | 0.0630574 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0627751 |
| POTEF | POTE ankyrin domain family, member F | 0.05932 |
| PCBP2 | poly(rC) binding protein 2 | 0.0586804 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0567982 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0550843 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.053198 |
| RYBP | RING1 and YY1 binding protein | 0.049027 |
| NAV2 | neuron navigator 2 | 0.0486776 |
| SEPTIN11 | septin 11 | 0.0482458 |
| MSN | moesin | 0.0470344 |
| DSPP | dentin sialophosphoprotein | 0.0462985 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0459647 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0453353 |
| SGMS2 | sphingomyelin synthase 2 | 0.0452732 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0451106 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.04264 |
| MYO5B | myosin VB | 0.040736 |
| GRB10 | growth factor receptor-bound protein 10 | 0.040531 |
| KIAA1217 | KIAA1217 | 0.0404926 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0400366 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.039002 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0387415 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0385799 |
| ZNF292 | zinc finger protein 292 | 0.0382458 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0382299 |
| RUNX1 | runt-related transcription factor 1 | 0.0377229 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0375136 |
| PRKCA | protein kinase C, alpha | 0.0372334 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0368678 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0365782 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.036433 |
| PTK2 | protein tyrosine kinase 2 | 0.0346184 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0346022 |
| SMAD3 | SMAD family member 3 | 0.034444 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0341565 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0335923 |
| G0S2 | G0/G1 switch 2 | 0.032876 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.032667 |
| YBX1 | Y box binding protein 1 | 0.0322351 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0319066 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0318582 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0315134 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.03099 |
| EGR1 | early growth response 1 | 0.0307604 |
| CENPF | centromere protein F, 350/400kDa | 0.0306523 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0298354 |
| ATXN1 | ataxin 1 | 0.029383 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.028923 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0289174 |
| PCM1 | pericentriolar material 1 | 0.0287339 |
| INTS6 | integrator complex subunit 6 | 0.0286378 |
| FOSL1 | FOS-like antigen 1 | 0.0284101 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0280542 |
| BRD2 | bromodomain containing 2 | 0.0273752 |
| ANO6 | anoctamin 6 | 0.027342 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0272028 |
| CD109 | CD109 molecule | 0.0271029 |
| UPP1 | uridine phosphorylase 1 | 0.0269894 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0269209 |
| SMYD3 | SET and MYND domain containing 3 | 0.0266555 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0264791 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0264086 |
| PGBD5 | piggyBac transposable element derived 5 | 0.0260781 |
| AREG | amphiregulin | 0.0260126 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0258781 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0257831 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0255085 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0251531 |
| DIAPH1 | diaphanous-related formin 1 | 0.0250381 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0249961 |
| NTN4 | netrin 4 | 0.0248469 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.024846 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0244579 |
| EGFR | epidermal growth factor receptor | 0.0243344 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0242194 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0241465 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0241378 |
| NPTN | neuroplastin | 0.0239157 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0238413 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0237059 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0236171 |
| VCL | vinculin | 0.0234148 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0232958 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0232295 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0231105 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0229032 |
| MYOF | myoferlin | 0.0228507 |
| RAD51B | RAD51 paralog B | 0.0228126 |
| RNF145 | ring finger protein 145 | 0.0226422 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0226334 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.19336 |
| ACTG1 | actin gamma 1 | -0.139982 |
| TMSB4X | thymosin beta 4, X-linked | -0.132723 |
| TMSB10 | thymosin beta 10 | -0.11177 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.111403 |
| LAMB3 | laminin, beta 3 | -0.10557 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0935661 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0920006 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0852754 |
| FN1 | fibronectin 1 | -0.075349 |
| CD2AP | CD2-associated protein | -0.0739075 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0732508 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0697212 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0695182 |
| TPM4 | tropomyosin 4 | -0.0666246 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0658232 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0651456 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0646644 |
| LMO7 | LIM domain 7 | -0.0633184 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0633025 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0630941 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0625146 |
| HLA-B | major histocompatibility complex, class I, B | -0.0623765 |
| FBXO32 | F-box protein 32 | -0.0619094 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0605136 |
| CSTB | cystatin B (stefin B) | -0.0599828 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0585257 |
| TMEM165 | transmembrane protein 165 | -0.0572876 |
| S100A6 | S100 calcium binding protein A6 | -0.0572569 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.055381 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0549904 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0546616 |
| EPCAM | epithelial cell adhesion molecule | -0.052324 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0505475 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0503128 |
| CCND1 | cyclin D1 | -0.0502283 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0498012 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0497553 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0493965 |
| HLA-E | major histocompatibility complex, class I, E | -0.0484474 |
| GNAS | GNAS complex locus | -0.048356 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0481537 |
| PLSCR1 | phospholipid scramblase 1 | -0.0469618 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.046703 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0457672 |
| HLA-A | major histocompatibility complex, class I, A | -0.0450918 |
| PGK1 | phosphoglycerate kinase 1 | -0.0449421 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0444576 |
| RPL35A | ribosomal protein L35a | -0.0441721 |
| CAVIN1 | caveolae associated protein 1 | -0.043705 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0433621 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0430647 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0429183 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0425068 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0419266 |
| RPL34 | ribosomal protein L34 | -0.0413952 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0408959 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0407551 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0407067 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0402843 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0389852 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0389638 |
| ERBIN | erbb2 interacting protein | -0.0388555 |
| H3-3B | H3.3 histone B | -0.03851 |
| LAMC2 | laminin, gamma 2 | -0.0383439 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0382115 |
| RAD21 | RAD21 homolog (S. pombe) | -0.038166 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.038074 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0378927 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0378721 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0376129 |
| CD63 | CD63 molecule | -0.0372382 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0369111 |
| CEP350 | centrosomal protein 350kDa | -0.0363812 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0363081 |
| SLMAP | sarcolemma associated protein | -0.0358224 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0355807 |
| MX1 | MX dynamin-like GTPase 1 | -0.0353555 |
| TMEM263 | transmembrane protein 263 | -0.0350725 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0345684 |
| SP100 | SP100 nuclear antigen | -0.034253 |
| ARF1 | ADP-ribosylation factor 1 | -0.0341857 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0337585 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0337026 |
| NF1 | neurofibromin 1 | -0.0333894 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0331894 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0330962 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0329065 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0323082 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.032292 |
| GOLGA4 | golgin A4 | -0.0321589 |
| CTSB | cathepsin B | -0.032129 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0320722 |
| SNX6 | sorting nexin 6 | -0.0320468 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0317677 |
| RNF213 | ring finger protein 213 | -0.0314578 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0313607 |
| ADAR | adenosine deaminase, RNA-specific | -0.0313532 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0310357 |
| FTL | ferritin, light polypeptide | -0.0310089 |
