| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | 0.0691986 |
| MYOF | myoferlin | 0.0561588 |
| DST | dystonin | 0.0489701 |
| VCL | vinculin | 0.0447974 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0446699 |
| LDHA | lactate dehydrogenase A | 0.0427779 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0417567 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0356949 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0347072 |
| NEK7 | NIMA-related kinase 7 | 0.0319481 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0294856 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0279946 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0272356 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0262884 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0255049 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0248171 |
| NRCAM | neuronal cell adhesion molecule | 0.0248101 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0247756 |
| MT2A | metallothionein 2A | 0.0242926 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0240399 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0236339 |
| RGS2 | regulator of G-protein signaling 2 | 0.0231285 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0231144 |
| KYNU | kynureninase | 0.0230885 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0229541 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0229406 |
| CD109 | CD109 molecule | 0.0229017 |
| PRELID2 | PRELI domain containing 2 | 0.0227907 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0222873 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0221372 |
| RPS12 | ribosomal protein S12 | 0.0220721 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0216902 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0212748 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0210833 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0210079 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0194535 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0194259 |
| NCAM1 | neural cell adhesion molecule 1 | 0.0193637 |
| NRG1 | neuregulin 1 | 0.0190267 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0189512 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0187488 |
| ANXA2 | annexin A2 | 0.01867 |
| BDNF | brain-derived neurotrophic factor | 0.0183553 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0183011 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0179 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0175688 |
| DISP1 | dispatched homolog 1 (Drosophila) | 0.0170489 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0170299 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0169741 |
| PGK1 | phosphoglycerate kinase 1 | 0.0169044 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0168494 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.0167497 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0167242 |
| CTSC | cathepsin C | 0.0161246 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0161065 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0160046 |
| RPLP0 | ribosomal protein, large, P0 | 0.0159168 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0158302 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0157657 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0154456 |
| ENO1 | enolase 1, (alpha) | 0.0153213 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0146423 |
| TPI1 | triosephosphate isomerase 1 | 0.0145441 |
| CLTC | clathrin, heavy chain (Hc) | 0.0145237 |
| PCBP2 | poly(rC) binding protein 2 | 0.0144668 |
| COPA | coatomer protein complex, subunit alpha | 0.0143201 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0142274 |
| MALT1 | MALT1 paracaspase | 0.0139506 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0135238 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.013477 |
| RPS4X | ribosomal protein S4, X-linked | 0.0134737 |
| KRT19 | keratin 19, type I | 0.013387 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0132828 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0131444 |
| GPC6 | glypican 6 | 0.0131187 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0127076 |
| EPHA4 | EPH receptor A4 | 0.0125602 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0125496 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0122978 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0122035 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0119885 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0119741 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.0118424 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0115518 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0115333 |
| SCFD1 | sec1 family domain containing 1 | 0.0114144 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0113494 |
| MARCHF1 | membrane associated ring-CH-type finger 1 | 0.0113416 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0112729 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0110192 |
| ATXN1 | ataxin 1 | 0.0109251 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0107736 |
| HJURP | Holliday junction recognition protein | 0.0106033 |
| CUL3 | cullin 3 | 0.0105528 |
| MORF4L2 | mortality factor 4 like 2 | 0.0105394 |
| PLCB4 | phospholipase C, beta 4 | 0.0105324 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0105296 |
| NRXN3 | neurexin 3 | 0.0104866 |
| CHSY3 | chondroitin sulfate synthase 3 | 0.010455 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.01045 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0911666 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0680229 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0665016 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.060298 |
| FN1 | fibronectin 1 | -0.0596972 |
| SMYD3 | SET and MYND domain containing 3 | -0.0571709 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0559959 |
| VIM | vimentin | -0.0539893 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0526404 |
| RPS6 | ribosomal protein S6 | -0.0508251 |
| PTMA | prothymosin, alpha | -0.0485014 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0453791 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0431693 |
| CTSL | cathepsin L | -0.0424561 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0409559 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0377528 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.03769 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0369453 |
| RPS23 | ribosomal protein S23 | -0.035274 |
| CDH13 | cadherin 13 | -0.0338638 |
| HLA-B | major histocompatibility complex, class I, B | -0.0323079 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0315399 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0314768 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0312759 |
| GDA | guanine deaminase | -0.0301955 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.029863 |
| PTGR1 | prostaglandin reductase 1 | -0.0291071 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0288627 |
| FTL | ferritin, light polypeptide | -0.0281669 |
| NCKAP5 | NCK-associated protein 5 | -0.0273935 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0271316 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0269678 |
| IL6 | interleukin 6 | -0.0269592 |
| OSMR | oncostatin M receptor | -0.0260079 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0256994 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0250896 |
| RPS27 | ribosomal protein S27 | -0.0246825 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0243997 |
| RPL35A | ribosomal protein L35a | -0.0241481 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0240396 |
| RPS8 | ribosomal protein S8 | -0.0239365 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0237637 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0233768 |
| RPL31 | ribosomal protein L31 | -0.0233324 |
| RPS29 | ribosomal protein S29 | -0.0229248 |
| RPL34 | ribosomal protein L34 | -0.0228378 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0226507 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0224638 |
| CUX1 | cut-like homeobox 1 | -0.022416 |
| TENM3 | teneurin transmembrane protein 3 | -0.0222024 |
| RPS19 | ribosomal protein S19 | -0.0221345 |
| RPL36A | ribosomal protein L36a | -0.0220148 |
| RPS11 | ribosomal protein S11 | -0.0214644 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0213561 |
| STEAP1B | STEAP family member 1B | -0.0212685 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0211921 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0206312 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0206022 |
| LAMB1 | laminin, beta 1 | -0.0201567 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0200695 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0197829 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.019706 |
| TBXT | T-box transcription factor T | -0.0196838 |
| RPS27A | ribosomal protein S27a | -0.019524 |
| RPLP2 | ribosomal protein, large, P2 | -0.0192972 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0189876 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0189812 |
| RPL38 | ribosomal protein L38 | -0.0189763 |
| RPS13 | ribosomal protein S13 | -0.0189414 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0186713 |
| PCDH15 | protocadherin-related 15 | -0.0186279 |
| STC1 | stanniocalcin 1 | -0.0186173 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0185468 |
| RPS14 | ribosomal protein S14 | -0.0182048 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0178034 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0177754 |
| FMNL2 | formin-like 2 | -0.0177479 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0175381 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0175244 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0175234 |
| RPS25 | ribosomal protein S25 | -0.0171712 |
| CXXC1 | CXXC finger protein 1 | -0.0171663 |
| MFF | mitochondrial fission factor | -0.0170105 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0166685 |
| TPM4 | tropomyosin 4 | -0.0166264 |
| MAP7 | microtubule-associated protein 7 | -0.0165498 |
| RPL36 | ribosomal protein L36 | -0.0165009 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0163073 |
| RPS21 | ribosomal protein S21 | -0.0162597 |
| RPLP1 | ribosomal protein, large, P1 | -0.0161694 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0152509 |
| MCL1 | myeloid cell leukemia 1 | -0.0152465 |
| RPL7A | ribosomal protein L7a | -0.0152235 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0149003 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0148678 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0147849 |
| GPRIN3 | GPRIN family member 3 | -0.014706 |
| KIAA0825 | KIAA0825 | -0.0144859 |
| RNF213 | ring finger protein 213 | -0.01448 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0144697 |
