| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Tofacitinib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Tofacitinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.12172 |
| EGFR | epidermal growth factor receptor | 0.119915 |
| HMGA2 | high mobility group AT-hook 2 | 0.119024 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.109531 |
| DST | dystonin | 0.0884087 |
| ASPH | aspartate beta-hydroxylase | 0.0852908 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0848606 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0821488 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0755992 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0729258 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0697733 |
| PDE10A | phosphodiesterase 10A | 0.0679006 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0670819 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0636318 |
| MYO1E | myosin IE | 0.0631745 |
| ANKRD17 | ankyrin repeat domain 17 | 0.062893 |
| RPS6 | ribosomal protein S6 | 0.0612042 |
| PLCB4 | phospholipase C, beta 4 | 0.0604216 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0601983 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0601699 |
| SLTM | SAFB-like, transcription modulator | 0.0586247 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0583575 |
| INHBA | inhibin, beta A | 0.0578553 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0577611 |
| GPC6 | glypican 6 | 0.0570132 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0568889 |
| ACTG1 | actin gamma 1 | 0.0559231 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.055856 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.054882 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0546256 |
| CD2AP | CD2-associated protein | 0.0509195 |
| GNAS | GNAS complex locus | 0.0506606 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0505237 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0491361 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0490511 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0488565 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0479841 |
| MYO10 | myosin X | 0.0478095 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0472479 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0471172 |
| EHBP1 | EH domain binding protein 1 | 0.0470291 |
| FLNB | filamin B, beta | 0.0460559 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0447207 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0444052 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0442131 |
| CDK13 | cyclin-dependent kinase 13 | 0.044027 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0435228 |
| PKM | pyruvate kinase, muscle | 0.0430863 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0430362 |
| HDAC9 | histone deacetylase 9 | 0.0419912 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0417693 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0417476 |
| PTK2 | protein tyrosine kinase 2 | 0.0409251 |
| ANXA2 | annexin A2 | 0.0409184 |
| INTS6 | integrator complex subunit 6 | 0.040649 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0406432 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.040587 |
| FAT1 | FAT atypical cadherin 1 | 0.0404934 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.040307 |
| SETD5 | SET domain containing 5 | 0.0402887 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0397441 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0395008 |
| NAV3 | neuron navigator 3 | 0.0388292 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0387958 |
| VMP1 | vacuole membrane protein 1 | 0.0385892 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0385271 |
| FAM13A | family with sequence similarity 13, member A | 0.0381308 |
| S100A10 | S100 calcium binding protein A10 | 0.0375512 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0374358 |
| RAI14 | retinoic acid induced 14 | 0.0374149 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0372378 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0371655 |
| TENM3 | teneurin transmembrane protein 3 | 0.0360937 |
| CD44 | CD44 molecule (Indian blood group) | 0.0359127 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0353687 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0353564 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0344357 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0342402 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0340782 |
| TJP1 | tight junction protein 1 | 0.0338182 |
| COL5A1 | collagen, type V, alpha 1 | 0.0337498 |
| RPL37A | ribosomal protein L37a | 0.0336326 |
| FN1 | fibronectin 1 | 0.0329423 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0328083 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0325038 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0324263 |
| SMAD3 | SMAD family member 3 | 0.0324034 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0317479 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.031341 |
| EFNA5 | ephrin-A5 | 0.0311331 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0308237 |
| LDHA | lactate dehydrogenase A | 0.0298412 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.029833 |
| PCBP3 | poly(rC) binding protein 3 | 0.0297945 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0294088 |
| WWOX | WW domain containing oxidoreductase | 0.029389 |
| GLIS3 | GLIS family zinc finger 3 | 0.0291305 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0286972 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0286653 |
| USP34 | ubiquitin specific peptidase 34 | 0.0282242 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.147929 |
| RPS16 | ribosomal protein S16 | -0.138518 |
| NAV2 | neuron navigator 2 | -0.109479 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.10405 |
| SNX9 | sorting nexin 9 | -0.0964979 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0884491 |
| RPLP1 | ribosomal protein, large, P1 | -0.0815156 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0796493 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0749535 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0746711 |
| ITGA6 | integrin, alpha 6 | -0.0682875 |
| STAG2 | stromal antigen 2 | -0.0662088 |
| RPLP2 | ribosomal protein, large, P2 | -0.0660807 |
| SP100 | SP100 nuclear antigen | -0.0656226 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0637687 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0635018 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0595329 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0594203 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0560851 |
| SPATA13 | spermatogenesis associated 13 | -0.0552437 |
| WASF2 | WAS protein family, member 2 | -0.053411 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0533457 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0526526 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.051318 |
| FNIP1 | folliculin interacting protein 1 | -0.050903 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0507169 |
| RBM25 | RNA binding motif protein 25 | -0.0506929 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.049325 |
| UBE2Z | ubiquitin-conjugating enzyme E2Z | -0.0490618 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0470289 |
| H1-0 | H1.0 linker histone | -0.0469411 |
| RPL26 | ribosomal protein L26 | -0.0468241 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0465375 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0462615 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.04597 |
| MYO5B | myosin VB | -0.0459295 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0457772 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0454308 |
| LMO7 | LIM domain 7 | -0.0451249 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0450248 |
| STK24 | serine/threonine kinase 24 | -0.044999 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0435805 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0434853 |
| IREB2 | iron-responsive element binding protein 2 | -0.0425511 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0425167 |
| KAT6B | K(lysine) acetyltransferase 6B | -0.0420961 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0416668 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | -0.0416091 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0412036 |
| LAMB3 | laminin, beta 3 | -0.040504 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0397089 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0390939 |
| SUB1 | SUB1 homolog (S. cerevisiae) | -0.0388558 |
| PATJ | PATJ crumbs cell polarity complex component | -0.038573 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0381795 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0379182 |
| PRPF38B | pre-mRNA processing factor 38B | -0.0377601 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0374837 |
| RPL37 | ribosomal protein L37 | -0.0369106 |
| TNPO1 | transportin 1 | -0.0366856 |
| SERINC5 | serine incorporator 5 | -0.0365895 |
| EGR1 | early growth response 1 | -0.0363146 |
| RPS24 | ribosomal protein S24 | -0.0360308 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0352498 |
| EZR | ezrin | -0.0352382 |
| UPF2 | UPF2 regulator of nonsense transcripts homolog (yeast) | -0.0352209 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0346941 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | -0.0346933 |
| CDK6 | cyclin-dependent kinase 6 | -0.0346206 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0345365 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0344497 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0341049 |
| FRMD5 | FERM domain containing 5 | -0.0340139 |
| JUN | jun proto-oncogene | -0.0339591 |
| JMJD1C | jumonji domain containing 1C | -0.0338676 |
| PERP | PERP, TP53 apoptosis effector | -0.0338022 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0335444 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0325576 |
| RNF13 | ring finger protein 13 | -0.0325275 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.03251 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0319571 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | -0.0307674 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0307201 |
| UBC | ubiquitin C | -0.0300673 |
| MED13 | mediator complex subunit 13 | -0.029987 |
| PGK1 | phosphoglycerate kinase 1 | -0.0294185 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.029373 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0287002 |
| MORF4L2 | mortality factor 4 like 2 | -0.0285754 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0284554 |
| KIF5B | kinesin family member 5B | -0.0276187 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0271395 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0268732 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0267857 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0263218 |
| LMNA | lamin A/C | -0.025985 |
| GLYR1 | glyoxylate reductase 1 homolog (Arabidopsis) | -0.0258428 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0256682 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0251465 |
| RPL4 | ribosomal protein L4 | -0.0251315 |
